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이여주 ( Yeo Joo Lee ),초가기 ( Jia Qi Chu ),이서용 ( Seo Yong Lee ),김수미 ( Su Mi Kim ),이광녕 ( Kwang Nyeong Lee ),고영준 ( Young Joon Ko ),이향심 ( Hyang Sim Lee ),조인수 ( In Soo Cho ),남석현 ( Seok Hyun Nam ),박종현 ( Jong H 한국가축위생학회 2011 韓國家畜衛生學會誌 Vol.34 No.2
Asia1/Shamir that has been recommended by World Reference Laboratory for foot-and-mouth disease (FMD) is used as a vaccine strain, and is being prepared in many countries including Korea. Although it is assumed that vaccine strain Asia1/Shamir has a wide antigenicity, sufficient molecular biological analysis has not been accomplished yet. Complete genome sequence analysis showed that the region with the most severe variations was 1D region of structural protein-coding sequence; particularly amino acid 141~157 residues in 1D region RGD sites for binding to susceptible cells. In addition, five amino acids in 1D region were identified as characteristic sites that are different from other known Asia1 viruses. Asia1/Shamir strain was shown to be genetically similar to group VI that had occurred in the Middle East, but showed low level of genetic similarity to the group V viruses that had occurred in the Southeast Asia and China. It is considered that, if these viruses, group I and II including group V are introduced into Korea, care would be paid in case of inoculating the vaccine strain Shamir available in Korea.
이여주 ( Yeo Joo Lee ),초가기 ( Jia Qi Chu ),이서용 ( Seo Yong Lee ),김수미 ( Su Mi Kim ),이광녕 ( Kwang Nyeong Lee ),고영준 ( Young Joon Ko ),이향심 ( Hyang Sim Lee ),조인수 ( In Soo Cho ),남석현 ( Seok Hyun Nam ),박종현 ( Jong H 한국가축위생학회 2011 韓國家畜衛生學會誌 Vol.34 No.2
Foot-and-mouth disease (FMD) is one of the most infectious diseases affecting cloven-hoofed animals including cattle, sheep, goats, and pigs. Seven serotypes of foot-and-mouth disease virus with multiple subtypes within each serotype have been identified until now. In particular, it has been demonstrated that the outbreak of the serotype Asia1 reported from China, Mongolia and North Korea since 2005 is mostly classified into genetic group V. Though it has been recommended that Asia1 Shamir strain can be used as a high priority vaccine by World References Laboratory for FMD, the complete nucleotide sequences of the strain has not yet been determined. In this study, to be prepared for Asia1 type viruses that may be brought into Korea, the complete genome sequence of this vaccine strain Asia1 Shamir including its 5` and 3` non-coding region was identified.
동아시아 유래 구제역바이러스 Asia1혈청형과 백신항원의 면역학적 상관성
박종현,고영준,김수미,이향심,이광녕,조인수,Park, Jong-Hyeon,Ko, Young-Joon,Kim, Su-Mi,Lee, Hyang-Sim,Lee, Kwang-Nyeong,Cho, In-Soo 대한수의학회 2009 大韓獸醫學會誌 Vol.49 No.3
Foot-and-mouth disease (FMD) is the most contagious disease of mammals. The use of inactivated vaccine can be chosen to prevent or control FMD. However, vaccination against one serotype of FMDV doses not cross-protect against other serotypes and may not protect fully against some strains of the same serotype. Appropriate selection of vaccine strain is an important element in the control of FMD. The immunity of vaccine antigens should be matched against newly circulating viruses. The phylogenetic analysis of serotype Asia1 reported from China, Mongolia, North Korea and Russia since 2005 shows that they are all classified into genetic group V, but the strain, Asia1/Shamir (ISR/89) which have been used as a vaccine strain in Korea, is clustered into different genetic group. So, in this study the serological relationship between the isolate (Asia1/MOG/05; MOG) and the Shamir strain was determined by ELISA and virus neutralization test. Even though the matching value of the virus (MOG) against the vaccinated sera in target animals was not so high, the vaccinated animals elicited antibodies enough for protection after vaccinated once or twice. Conclusively, we suggest that the vaccine containing Asia1/Shamir antigen could protect the genetic group V strains circulating in East Asia currently if vaccinated twice or the more.
박종현 ( Jong Hyeon Park ),이광녕 ( Kwang Nyeong Lee ),김수미 ( Su Mi Kim ),고영준 ( Young Joon Ko ),이향심 ( Hyang Sim Lee ),조인수 ( In Soo Cho ) 한국가축위생학회 2010 韓國家畜衛生學會誌 Vol.33 No.2
Foot-and-mouth disease (FMD) commonly infects cloven-hoofed livestock animals such as cattle, pig, sheep, and goat and its clinical signs are well-known. Besides livestock, FMD can be transmitted among cloven-hoofed animals in the wild. FMD mostly affects livestock animals in farms, but, wild animals are likely to play a pivotal role in spreading the disease due to their way of free living. In the case of deer, the clinical signs of FMD vary widely from subclinical to severe infections. Thus, in some deer species, it may be hard to verify clinical signs of FMD. A deer may carry the virus up to 11 weeks after exposure, shedding the virus during the period. However, deer is not considered as a typical host for persistent infection like buffalo, cattle or sheep. In Korea, small-scale livestock farms which have less than 10 animals make up 63.6% of the entire livestock farms. Considering raising environment in deer farms, it is assumed that the risk of virus excretion and consequent transmission of FMD among deers is relatively lower than other cloven-hoofed animals. However, Sika deer and Elk which are typical deer species in Korea would manifest mild to subclinical symptoms upon FMD infection. Therefore, laboratory testing is necessary to confirm FMD in these animals because of difficulty in verifying clinical signs and the risk of virus shedding during inapparent infection.
주요 혈청형 구제역바이러스의 발생분포와 분자역학적 분석
박종현 ( Jong Hyeon Park ),이광녕 ( Kwang Nyeong Lee ),김수미 ( Su Mi Kim ),고영준 ( Young Joon Ko ),이향심 ( Hyang Sim Lee ),조인수 ( In Soo Cho ) 한국가축위생학회 2009 韓國家畜衛生學會誌 Vol.32 No.4
Foot-and-mouth disease (FMD) virus exists in seven serotypes and is known to be a highly contagious disease that is hard to eradicate from the world. The O, A, Asia1 and SAT2 serotypes commonly infected cattle, sheep and goats during 2007~2009 throughout the world. In particular, the outbreak of the Asia1 serotype in China appeared in all areas from 2005 and is still present. Surprisingly, in 2009, Taiwan reported the first outbreak of the type O serotype since 2001. Then type A appeared in China for the first time since the early 1960s. The virus shows a close relationship to the viruses from Southeast Asia suggesting one or more recent introductions into China in the OIE reports. Recently the subtype of A/Iran05 spread to nearby countries exhibiting genomic evolution. The use of molecular epidemiology is an important tool in understanding and consequently controlling the FMD virus. The phylogenetic analysis with VP1 gene was especially useful for molecular epidemiological studies and showed the same pattern which matches with serotype classification. This paper describes basic information about the disease, and the serotype-specific characteristics and evolution to perform molecular epidemiological analysis. Furthermore, we show the importance of the genetic evolution on the FMD serotypes in global surveillance and molecular epidemiology of FMD for outbreak investigation.