Calcipotriol 연고와 단일파장 자외선 B 복합요법의 건선에 대한 치료 효과

윤현선 ( Hyun Sun Yoon ),조성진 ( Seong Jin Jo ),윤재일 ( Jai Il Youn ) 대한피부과학회 2005 대한피부과학회지 Vol.43 No.10

얼굴 건선 환자에 대한 임상적 연구

윤현선 ( Hyun Sun Yoon ),박제영 ( Je Young Park ),윤재일 ( Jai Il Youn ) 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.12

Background: Many clinicians tend to assume that psoriasis rarely involves the face, and therefore have little interest in facial psoriasis. However, the face is the most important area of cosmetic concern and social activity, and facial involvement of psoriasis is more common than we think. A few reports have even suggested that facial psoriasis could be a marker of severe psoriasis. Objective: To investigate the epidemiological and clinical characteristics of facial psoriasis. Methods: A total of 235 patients with facial psoriasis were enrolled in this retrospective study at the psoriasis clinic, Department of Dermatology, Seoul National University. Epidemiological and clinical data from patient records was collected and analyzed. Results: The most frequent age of onset for facial psoriasis was in the 3rd decade of life. The peak age of onset of facial psoriasis in male patients was in the 3rd and 4th decade of life, whilst for female patients it was in the 3rd decade. Most patients had presented with facial psoriasis before they were 40. The sites of the face most often affected were the upper (73.9%) and lower (46.2%) aspects of the forehead and periauricular area (45.7%). The eyelid, perioral area and nasolabial fold were relatively unaffected. Patients who had scalp-unrelated facial psoriasis presented with a more severe condition than patients who only had scalp-related facial psoriasis. With reference to the extent of psoriasis, 43.8% of patients were moderate cases, whereas 29.6% were mild and 26.6% were severe. With reference to the activity, 40.3% of patients were mild, while 38.5% were moderate and 21.2% were severe. Family history was observed in 39.9% of patients and nail involvement was observed in 27.7% of patients. Only 38.2% of patients had no pruritus, while 16.3% of patients experienced moderate or severe pruritus. Conclusion: The present retrospective analysis contributes to our understanding of the clinical characteristics of facial psoriasis. (Korean J Dermatol 2006;44(12):1397~1402)

Calcitriol 연고를 이용한 얼굴 건선의 치료

조성진 ( Seong Jin Jo ),윤현선 ( Hyun Sun Yoon ),윤재일 ( Jai Il Youn ) 대한피부과학회 2005 대한피부과학회지 Vol.43 No.11

Acropustulosis of Infancy

정영철(Young Chul Jung),이기호(Ki Ho Lee),허충림(Choong Rim Haw),윤재일(Jai Il Yoon),임수덕(Soo Duk Lim) 대한피부과학회 1983 대한피부과학회지 Vol.21 No.2

Acropustulosis of infancy is an uncommon, but not rare syndrome established as a new disease entity by Kahn and Rywlin(1976), which is characterized by recurrent, intensely pruritic vesicopustules on the distal extremities. We'd like to report a case of acropustulosis of infancy. Our patient was 19 month old girl who had been suffering from her skin disease since the age of 12 months. Intensely pruritic, 1 to 2 mm vesicopustules erupted on the palms, soles and the ventral aspects of the fingers. There were no bacteria, fungus and parasites(Sarcoptes scabiei) on the pustular lesions. Histopathologically, biopsy specimen of the left sole revealed large, well circumscribed intraepidermal pustule which was filled wth polymorphonuclear leukocytes. We confirmed our case as typical case of acropustulosis of infancy by it's characteristic clinical features and histopathologic findings. Severity of the skin lesions seems closely related to the dosage of dapsone. The eruptions were unresponsive to topical steroid, antibiotics and antihistaminics. But we observed that dapsone has dose dependent relationship with acropustulosis of infancy.

홍색음선 (紅色陰癬)

서웅석(Woong Suck Suh),이기호(Ki Ho Lee),허충림(Choong Rim Haw),윤재일(Jai Il Yoon),임수덕(Soo Duk Lim) 대한피부과학회 1983 대한피부과학회지 Vol.21 No.1

Erythrasma is a chronic, superficial bacterial skin infection involving the body folds and toewebs, and sametimes it may be generalized. The causative organism of this disease is Corynebacterium minutissimum. But, in Korea, there are few reported case about this common condition. We experienced a case of erythrasma on 39-year-old male who have had well defined, brownish fine scaly patches on both crural areas for 15 years. We had treated this patient with topical antifungal agent for 1 month under impression of tinea cruris, But skin lesion was not improved. So, we reexamined the lesion and diagnosed it as genitocrural form of erythrasma with it's clinical appearance, red fluorescence under Wood's light. And we treated it with oral erythromycin.

간기능 검사 이상을 보이는 건선환자에서 비알코올성 지방간의 유병률 및 임상양상

이재인 ( Jae In Lee ),서현이 ( Hyun Yi Suh ),배주윤 ( Joo Yoon Bae ),정혜정 ( Hye Jung Jung ),안지영 ( Jiyoung Ahn ),박미연 ( Mi Youn Park ),윤용범 ( Yong Bum Yoon ),윤성환 ( Sung Hwan Youn ),윤재일 ( Jai Il Youn ) 대한피부과학회 2020 大韓皮膚科學會誌 Vol.58 No.10

Background: Non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease. Evidence supporting a strong relationship between psoriasis and NAFLD exists. NAFLD is significantly higher in psoriatic patients than in matched controls and psoriatic patients with NAFLD have more severe forms of psoriasis than those without NAFLD. Objective: To evaluate the prevalence and clinical features of NAFLD among Korean psoriatic patients with abnormal liver function tests. Methods: We evaluated the laboratory results of psoriatic patients who visited the Department of Dermatology, National Medical Center, between September 2012 and June 2017. Those who had abnormal liver function tests were consulted by a hepatologist to confirm the diagnosis of NAFLD using ultrasonography. Results: A total of 307 psoriatic patients underwent liver function tests (LFTs), and 46 patients (15.0%) had abnormal LFT values. A hepatologist consulted psoriatic patients with abnormal LFTs, and hepatic ultrasonography was performed; 34 patients (73.9%) were diagnosed with NAFLD. Among psoriatic patients with abnormal LFTs, those with a Psoriasis Area and Severity Index (PASI) ≥10 had a significantly higher rate of NAFLD than psoriatic patients with PASI <10 (87.5% vs 59.1%). Conclusion: Among psoriatic patients with abnormal LFTs, 34 patients (73.9%) were diagnosed with NAFLD. Psoriatic patients with PASI ≥10 had a significantly higher rate of NAFLD than those with PASI <10. (Korean J Dermatol 2020;58(10):650∼655)

한국인 건선환자에서 발병하는 질환에 대한 연구 - 다기관 연구

김광호(Kwang Ho Kim),전현진(Hyun Jin Jeon),김광중(Kwang Joong Kim),윤재일(Jai Il Youn),김낙인(Nack In Kim),김태윤(Tae Yoon Kim),최지호(Jee Ho Choi),박기범(Ki Beom Park) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.7

N/A Background: The prevalence of other diseases associated with psoriasis has been investigated in recent years. Objective: This study was performed to see diseases associated with psoriasis in Korea. Methods: From September 1999 to May 2000, a total of 293 patients with psoriasis, who visited the department of dermatology in 6 hospitals, were enrolled in a subject group for the study. We surveyed the incidence rates of associated diseases. Results: In our study, diseases more concomitantly present in patients with psoriasis were dermatophyte infection, seborrhea dermatitis and benign tumor & nevus in skin diseases and obesity, diabetes mellitus, hypertension, gastritis and hepatitis in systemic diseases. Less concomitantly present in-patients with psoriasis were erythroderma, acne, contact dermatitis, atomic dermatitis, bacterial infection, tonsillitis, and internal cancer. Conclusion: Our observations show a distinct pattern of diseases associated with psoriasis in Korea. Further investigation will be mandatory to elucidate concomitant diseases in psoriasis. (Korean J Dermatol 2001;39 (7): 743~748)

한국인 건선의 악화요인에 관한 연구

윤재일,박병순,김상덕 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.7

Background: Psoriasis is a chronic relapsing disorder which is influenced by various external factors. A study involving a large number of patients with objective assessment methods may help us to elucidate correlations between external factors and the course of psoriasis. Objective: Our purpose was to investigate the basic demographic data of psoriasis in a large number of Korean patients and to correlate disease activity, area of involvement with various external factors known to improve or worsen psoriasis. Methods: Epidemiological and clinical data with particular reference to the extent and activity of the condition in 1,600 psoriasis patients between 1982 and 1998 were collected and analysed. Results: 1. Patients in their twenties were most common(28.7%). There were no sexual predominance in our patients. 2. With reference to the extent of this skin condition, 43.4% of patients were mild cases, 38.3% were moderate and 18.3% were severe. 3. With reference to the activity, 42.9% of patients were mild cases, 26.5% were moderate and 30.6% were severe. 4. The most common morphological features were nummular types(55.8%), followed by large plaque types(23.4%) and guttate types(14.5%). 5. 57% of patients experienced a11eviation of their lesions in summer while 65% of patients experienced aggravation in winter. 6. 55% of the patients experienced improvement of their lesions in sunlight exposure whereas 7% of the remainder experienced aggravation. 7. 64% of the patients replied that their lesions tend to aggravate after a stressful event. 8. Among those who experienced pregnancy, 40% replied that their lesions improved while being pregnant. On the other hand, 19% experienced aggravation. 9. Severe forms were overwhelming in large plaque types in relation to extent and activity (p$lt;0.05). 10. Among the external factors investigated, stress showed statistically signficant association with the severity of psoriasis classified by extent and severity(p$lt;0.05). Conclusion: We investigated the epidemiological and clinical features of psoriasis in a large number of Korean patients in relation to various external factors. The condition in more than half of the patients was moderate or severe with reference to the extent and activity. Among external factors, stress seemed to have significant correlations with increased frequency in severe psoriasis patients.

건선에서 병발한 유전분성 태선 1예

윤재일,박석범,김상덕 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.7

Psoriasis is merely recognized as a disorder associated with pruritus. But in some cases, psoriasis does induce pruritus which could alter the daily lives of the people affected. Pruritus in psoriasis has been reported to be influenced by various external and internal factors and as a consequence, aggravation of psoriasis is possible by scratching due to the well-known Koebners phenomenen. Lichen amyloidosis, on the other hand, appears as multiple papules with intense pruritus. Recently, there are some evidence emphasizing pruritus as a main factor in forming amyloid deposits. We report a case of 65-year-old lady who was suffering psoriasis for 25 years with associated pruritic papular lesions on both of her thighs, knees and ankles. The diagnosis of Lichen amyloidosis was confirmed by Periodic Acid Schiff and Dylon stain. We discuss the role of pruritus in lichen amyloidosis and psoriasis and speculate that pruritus induced by lichen amyloidosis may induce a vicious cycle in aggravating psoriasis.

Narrow Band UVB를 이용한 건선의 광치료

윤재일,박석범,최용범 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.3

Background:Narrow-band UVB phototherapy using 311±2nm wavelength is in widespread use due to its greater efficacy and, possibly, safety compared with broad-band UVB sources. Objective:We performed emollient narrow-band UVB(NBUVB) phototherapy to evaluate the clinical efficacy and safety in Korean psoriasis patients. Methods:Fifteen psoriasis patients received narrow-band UVB phototherapy. We categorized each patient into clearing, improvement, or failure groups based on the therapeutic efficacy, and measured the PASI score every two weeks. Results: 1. Among patients who received narrow-band UVB phototherapy, clearing was shown in 40.0% and improvement in 27.7%, and failure in 33.3%. 2. The total number, duration, final and cumulative doses to achieve grade IV were 16.3, 39 days, 1,050mJ/cm2 and 12,125mJ/cm2 respectively. 3. There were some side effects of NBUVB phototherapy such as pruritus(53.3%) and mild burning(13.3%). Conclusion:Narrow-band UVB phototherapy is a effective treatment modality which is convenient and less erythemogenic in psoriasis. It will be used more and more and play an important role in the treatment of psoriasis.