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2, 4, 5-Trichlorophenoxyacetic Acid 분해균의 유전적 특성에 관한 연구
윤소영,송홍주,이건,이상준,이종근,Yoon, So-Yeong,Son, Hong-Joo,Lee, Geon,Lee, Sang-Joon,Lee, Jong-Kun 한국미생물학회 1992 미생물학회지 Vol.30 No.4
2, 4, 5-T 분해균주인 Pseudomonas sp. EL-071P 는 rifampicin, ampicilin, kanamycin 등의 중금속에 대하여 내성을 가지고 있었다. 이 균주로부터 2, 4, 5-T 분해능과 rifampicin 의 내성에 관련된 하나의 plasmid 를 분리, 정제하였으며 그 크기는 약 40 kb 이었다. E. coli 에 2, 4, 5-T 분해능에 관ㅎ련된 plasmid 를 transformation 한 결과 2, 4, 5-T 분해에는 plasmid 가 관여함을 확인할 수 있었다. 이 균주는 다양한 염소계방향족 동족체화합물을 유일한 탄소원으로 하여 생육할 수 있었으며, chlorophenol compound 의 경우 CI$^{-}$ 의 치환위치가 ortho, para-, meta- 위치순으로 분해가 잘 되었다. 2, 4, 5, -T 의 기질 유사체인 4-chlorophenol 에 의해 2, 4, 5-T 대사가 저해되었다. 비염소계 방향족화합물중 benzoate, salicylate, toluene 은 Pseudomonas sp. EL-071P 와 Pseudomonas putida KCTC 1643 에 의해 탄소원으로 이용되었으나 naphtalene 의 경우 Pseudomonas sp. EL-071 에 의해서만 탄소원으로 이용되어 표준균주인 Pseudomonas putida KCTC 1643 과 상이한 결과를 나타내었다. Pseudotnorju.c sp. EL-071P degrading 2.4.5-trichlorophe~~oxyi~cetaicci d (2.3.5-T) was resistantto antibiotics: rifampicin. ampicillin. kanamycin and metal ions : Zn" and Cu".The plasmitl related to the degradation of 2.4.5-'r and rifa~npicin resistance was isolatecifrom the strain. Its size was about 40 Kb. As result of transforming the plasmid intoEsch~rirhiti coli MClOhl, it was confirmed that the plasmid ura.; related to 2.4.5-T degradation.The strain coulil grow in the various chlorinated aromatic analogs as the solc carbon source.In the case of chlorophcnols. the chlorinated mono-substituteti phenols were easily dcgradetlin the order ol' ortho-. ~ ~ a r um- ,c ~tu-position.T he 2.3.5-T mctaholism was inhibited by 4-chlorophenol of 2.4.5-7' analog. In non-chlorinateci aromatics. ~ C I I L O ~ I ~ Csa.l icylilte i~ndtoluene were uscd ax the carbon source by the strain and typestrain Acudonlotrtr.\ plrtirltrKCTC 1643 having clegrad;~bility of various aromatics. But naphtalene was usecl only bythe A~urlomonri.\ sp. EL-07 1 P.the A~urlomonri.\ sp. EL-07 1 P.
윤소영 ( So Yeong Yoon ),김경훈 ( Kyoung Hoon Kim ),서기범 ( Ki Beom Suhr ),이정덕 ( Jeong Deok Lee ),송계용 ( Kyae Yong Song ),박장규 ( Jang Kyu Park ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.6
Pseudo-kaposi's sarcoma is a vasoproliferative disorder that may resemble Kaposi's sarcoma, clinically and histologically. In most cases, it has been associated with congenital or iatrogenic arteriovenous fistula and chronic venous insuffiency. We present a 36-year-old male patient with pseudo-Kaposi's sarcoma caused by a deed vein thrombosis in the absence of any detectable underlying etiologic factors. (Kor J Dermatol 1995;33(6): 1159-1163)
윤소영 ( So Yeong Yoon ),김경훈 ( Kyung Hoon Kim ),서기범 ( Ki Beom Suhr ),박장규 ( Jang Kyu Park ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.3
The superior vena cava syndrome can occur when an extrnsc compression or intralurninal occlusion impedes blocxl flow through this vessel. We report a case of superior vena cava syndrome with tirc nbophlebitis on the right forearm in 57 year old male patient who used steroids (p.o) for 25 years. (Kor J Dermatol 1995;33(3): 570-574)
천공성 및 피하성 환상 육아종을 동반한 전신성 환상 육아종
윤소영 ( So Yeong Yoon ),김경훈 ( Kyung Hoon Kim ),서기범 ( Ki Beom Suhr ),박장규 ( Jang Kyu Park ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.6
We present a case of generalized grannuloma annulare with perforating and subcutaneous forms which occurred in a 15-year-old girl. Two years ago, multiple umbilicated, match head to pea sized, erythematous papules were noted on the upper extremities. Then the patient also experienced crusted or ulcerated erythematous papular lesions on the lower legs. Recently, tender, subcutaneous nodules appeared on both soles. The biopsy specimens from the skin lesions of the hand and the sole showed typical findings of granuloma annulare in the dermis and the subcutis, respectively. On the histopathological examination of the calf lesion, palisading granuloma as well as transepidermally eliminating dermal collagenous and necrotic material were seen. The skin lesions were almost completely improved by treatment with dapsone, 100mg a day, for 8 weeks orally. (Kor J Dermatol 1995;33(6): 1119-1123)
개피참진드기 ( Haemaphysalis flava ) 에 의한 참진드기 교상
윤소영 ( So Yeong Yoon ),김경훈 ( Kyung Hoon Kim ),서기범 ( Ki Beom Suhr ),조백기 ( Baik Kee Cho ),남인환 ( In Hwan Nam ),이원구 ( Won Koo Lee ),이증훈 ( Jeung Hoon Lee ),박장규 ( Jang Kyu Park ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.2
We report a case of tick bite caused by Haemaphysalis flava which have never been reported in Korean medical literature. An 31-year-old woman had a asymptomatic erythematous indurated plaque with central crust by tick bite on the left upper back. A excisional biopsy specimen from the skin lesion showed eosinophilic degeneration with thrombosed blood vessels and dense inflammatory cells infiltration mainly composed of eosinophils in the reticular dermis. We could identify this causative tick as Hamaphysalis flava by using the scanning electron microscopic examination. (Kor J Dermatol 1996;34(2): 326-330)
윤소영(So-Young Yoon),김정호(Jeong-Ho Kim),고태성(Tae-Sung Ko),최충곤(Choong-Kon Choi),공경엽(yeong-Yeop Kong) 대한소아신경학회 1997 대한소아신경학회지 Vol.5 No.1
Canavan disease(CD) is a rare autosomal recessive leukodystrophy caused by the deficiency of aspartoacylase and the accumulation in brain of N-acetylaspartate(NAA). CD has been reported mainly Ashkenazi Jews but also occurs in other ethnic groups. Usually it presents as early as the third month of life with megalencephaly, hypotonia later progressing to hypertonia, psychomotor and mental retardation, blindness, occasionally deafness and seizure. Diagnosis is based on the clinical feature, N-acetylaspartic aciduria, radiologic and pathologic findings. Histologically, the affected white matter shows extensive vacuolation and demyelination. There is no treatment for CD and the only prevention is through genetic counselling and prenatal diagnosis. We experienced a case of Canavan disease that was presented with hypotonia and developmental delay. Diagnosis was confirmed histologically. Radiologic findings are extensive high signal throughout the white matter on T2-weighted MRI and increased NAA peak and decreased choline peak of the white matter on MR spectroscopy.
박장규 ( Jang Kyu Park ),김연수 ( Youn Soo Kim ),노영우 ( Young Woo Rho ),윤소영 ( So Yeong Yoon ),김태원 ( Tae Won Kim ),이웅재 ( Woong Jae Lee ),서기범 ( Ki Beom Suhr ),이증훈 ( Jeung Hoon Lee ) 대한피부과학회 1998 大韓皮膚科學會誌 Vol.36 No.2
Background: It is mandatory to measure the minimal phototoxic dose(MPD) in order to determine adequate irradiation of UV-A in photochemotherapy. However, the measurement of MPD is not easy in some cases due to inadequte size and site of lesions, time and manpower. Objective : The purspose of this study was to standardize the minimal phototoxic dose for a vitiliginous lesion. Methods : The minimal phototoxic dose of UV-A was measured in 82 vitiligo patients. Then we analyzed the MPD according to the sex, age, site of the vitiliginous lesions, duration of disease, and administration route of the photosensitizer. Results : 1. There were no significant differences between exposed and unexposed areas in MPD in both cases of topical and systemic administration of the photosensitiser. 2. There was no significant correlation between disease duration and MPD in both cases of topical and systemic administration of the photosensitiser. 3. In the group of topical application of 8-methoxypsoralen cream, MPD for males and females were 0.53+0.38J/cm2 and 0.48+0.32J/cm2 respectively without significant difference in sex. 4. In the group of systemic administration of 8-methoxypsoralen, there was a significant difference between males and females in MPD. The MPD in males and females were 1.38+0.72J/cm2 and 2.51 + 1.40J/cm2, respectively. 5. In the group of topical application of 8-methoxypsoralen cream, the MPD in 2nd decade patients was the highest(0.80+0.55J/cm2). The MPD had a tendency to decrease gradually as age receded from the 2nd decade. 6. In the group of systemic administration of 8-methoxypsoralen, there was a tendency for the MPD to be increased according to age without statistical significance. 7. MPD in the group systemically administrated with 8-methoxypsoaralen was four-fold to that of the topical application group. Conclusion : It may be valuable to keep in mind that there was a statistical differrence in MPD between sexes in systemic administration of the photosensitizer, and that MPD was different according to patients age in the topical application group. (Korean J Dermatol 1998;36(2): 241-245)
Triptolide의 말초와 중추투여에 의한 흰 쥐의 안면부 통증경감효과
김윤경 ( Yun Kyung Kim ),최자형 ( Ja Hyeong Choi ),이현정 ( Hyun Jung Lee ),손유진 ( Yoo Jin Son ),윤소영 ( So Yeong Yoon ),이정화 ( Jung Hwa Lee ),이민경 ( Min Kyung Lee ) 한국치위생과학회 2015 치위생과학회지 Vol.15 No.4
The aim of this study was to investigate whether peripheral or central administration of triptolide is involved in pain modulation in inflammatory orofacial pain. The inflammatory orofacial pain was induced by the injection of 5% formalin into right vibrissa pad of rats. The pain behavioral response was measured the number of grooming or scratching on the orofacial area for 9 successive 5 minutes intervals. Triptolide was administrated into the identified vibrissa pad (12.5, 25, 50 ug/50 ul) or intracisternal space (0.01, 0.1, 1 ug/10 ul) 10 min before formalin injection. The nociceptive responses were reduced in the 2nd phase (11∼45 minutes), particularly 20, 30 minutes after fomalin injection following administration of triptolide into vibrissa pad (25, 50 ug/50 ul). Intracisternal (1 ug/10 ul) administration of triptolide alleviated the formalin-induced pain behaviors in the 2nd phase, especially 25∼40 minutes after formalin injection. Triptolide could be a promising analgesic agent in the treatment of inflammatory orofacial pain.