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      • SCOPUSKCI등재

        각종 갑상선질환에서 혈청 갑상선홀몬치의 진단적 의의

        한봉헌,고석만,윤상룡,노흥규,Han, Bong-Heon,Ko, Suk-Man,Yoon, Sang-Ryong,Ro, Heung-Kyu 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.2

        In an attempt to evaluate the diagnostic significance of the serum thyroid hormones in various thyroid function states, the author measured serum $T_3$ uptake, serum $T_3$, serum $T_4$, serum free $T_4$ and free $T_3$ index in 27 cases of normal subjects, 11 cases of hypothyroidism, 152 cases of euthyroidism and 81 cases of hyperthyroidism by the radioimmunoassay method. The results were as follows: 1. The ranges of serum thyroid hormones in normal subjects were, serum $T_3$ uptake; $27.4{\sim}42.1%$, serum $T_3;\;93{\sim}245ng/dl$, serum $T_4;\;4.08{\sim}12.9ug/dl$ and serum free $T_4;\;0.57{\sim}1.53ng/dl(M{\pm}2S.D.)$. 2. Free $T_4$ index and serum $T_4$ show relatively high diagnostic value in euthyroidism group, and serum $T_3\;and\;T_4$ in hypothyroidism group, while serum $T_3$, free $T_4\;and\;T_4$ show relatively high diagnostic value in hyperthyroidism group. 3. There were significant correlation between free $T_4$ index and serum $T_4$(r=0.68), and between free $T_4$ index and serum free $T_4$(r=0.67) in hyperthyroidism group.

      • KCI등재후보
      • 철결핍성빈혈에서 혈청 Ferritin치에 관한 연구

        윤상룡 충남대학교 의과대학 지역사회의학연구소 1979 충남의대잡지 Vol.6 No.2

        The serum, ferritin levels by radioimmunoassay were measured in toe subjects of normal, iron deficiency anemia and non-iron deficiency anemia and was compared with serum iron total iron binding capacity and percentage saturation of transferrin. The followings were obtained. 1. There were significant decrease in serum iron (62.7±24.4㎍/dl, p<0.05) and significant increase in total iron binding capacity(324.2±76.7㎍/dl, p<0.005) in iron deficiency anemia, but there was no significant relationship in non-iron deficiency anemia, in contrast to normal control. 2. The serum ferritin levels were decreased significantly in iron deficiency anemia (13.9±10.7ng/ml, p<0.005) than normal control (82.5±48.0ng/ml). But serum ferritin levels in non-iron deficiency anemia showed wide variation (364.5±395.8ng/ml). 3. There was no significant correlation between serum iron, total iron binding capacity and serum ferritin in iron deficiency anemia, but serum ferritin was more significant in the diagnosis of iron deficiency anemia. 4. In non-iron deficiency anemia, there was no significant correlation and diagnostic significance between serum iron, total iron binding capacity and serum ferritin. 5. In iron deficiency anemia, the serum ferritin levels had no significant correlation with degree of anemia, but was tendency of correlation with percentage of transferrin iron saturation. 6. In liver diseases, blood dyscrasias and typhoid fever, the serum ferritin revealed very high levels in spite of moderate to marked degree of anemia.

      • SCOPUSKCI등재

        각종 갑상선 질환에서 혈청 Thyroxine 결합글로부린 (TBG) 의 진단적 의의

        노흥규,한봉헌,이헌영,고석만,윤상룡 대한핵의학회 1981 핵의학 분자영상 Vol.15 No.2

        In an attempt to evaluate the diagnostic significance of the serum thyroxine binding globulin(TBG) in various thyroid disease states, the authors measured serum T3 uptake, T3, total T4, free T4, TSH and TBG by radioimmunoassay technique, and calculated the free T4 index(FT4I) and T4/TBG ratio in 10 cases of normal subjects, 11 eases of hypothyroidism, 62 cases of euthyroidism and 37 cases of hyperthyroidism. The data were analysed in the aspects of diagnostic significance in each thyroid disease state, and the results were as follows; 1) In 10 cases of normal subjects, serum TBG was 17.4∼26.8ug/ml, FT4I was 5.1∼9.7, and T4/TBG ratio was 21.9∼49.9(Mean±S.D.). 2) 62 cases of euthyroidism with diffuse and nodular goiter, FT4I was 7.26±1.82, T4/TBG ratio was 31.47±10.42, and there were no significant difference from those of normal subjects(p〉0.5). 3) In 11 cases of hypothyroidism, the FT4I was 3.13±2.15, T4/TBG ratio was 11.3±5.31, significantly lower than normal controls(p〈0.01). 4) In 37 cases of hypsm, the FT4I was 30.0±12.01 T4/TBG ratio was 121.4±62.2, significantly higher than normal controls(p〈0.01). 5) There were significant correlations between the FT4I and T4/TBG ratio, total T4 and T4/TBG radio, in each thyroid function states. 6) The FT4I showed 100% of diagnostic value in hyperthyroidism, 89.2% in euthyroidism, and 80% in hypothyroidism group. The T4/TBG ratio showed 100% of diagnostic value in hyperthyroidism and hypothyroidism, and 80.6% in euthyroidism group. The above results suggest that T4/TBG ratio and FT4I showed same diagnostic value in hyperthyroidism group, but T4/TBG showed higher diagnostic significance than FT4I in hypothyroidism.

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