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유경재,강창수 啓明大學校 醫科大學 1986 계명의대학술지 Vol.5 No.2
Dupuytren's contracture is characterized by progressive fibroplasia and contracture of palmar fasica with resultant deformity of hands and fingers. Reccently it has been shown that the cellular element, called myofibroblast, contributes significantly to the process of contracture. Among the 6 patients we have seen during the last few years, there were a total of 9 hands with Dupuytern's contracture. Seven of these were treated by a partial fasciectomy or by a dermofasciectomy with a full thickness skin graft and the results of these two procedure were compared. The results of ermofasciectomy with full thickness skin graft are better than those of partial fasciectomy, and no local recurrences in the operative site after dermofasciectomy with full thickness skin graft. Electron microscopic studies were done to find myofibroblasts which have characteristics of both fibroblasts and smooth muscle cells in 3 of 6 patients and myofibroblasts were found in 2 of them.
유경재,장은숙 啓明大學校 醫科大學 1992 계명의대학술지 Vol.11 No.1
For the elucidation of a possible immunopathogenesis that leads to morphological and functional renal injury induced by alcohol abuse, immunopathologic and ultrastructural studies were carried out on animal models ; male Sprague-Dawley rats were fed a regular diet with 3ml of 40% and 4ml of 10% alcohol for 3 days to 12 weeks. The control group animals were fed a regular diet with 3ml of normal saline daily insteas of alcohol. The experimental animals were sacrificed on the 3rd, 5th and 7th day, 4th, 8th, and 12th week. The kidney, liver and small intestine were examined by light and electron microscopy, and the kidney and small intestine were also examined by immunofluorescence microscopy. No pathologic findings were observed byu light microscopy in 25 alcoholic and 6 control kidney samples. In one out of four rats after 8 weeks and three out of four rats after 12 weeks of 40% alcohol ingestion the IgA nephropathy (IgAN) with dominant mesangial IgA deposits on immunofluorescence microscopy and mesangial electron dense deposits on electron microscopy were observed. These IgAN cases also showed depositions of IgM, IgG and C3. Albuminuria (3+) and proteinuria (300mg/dl) were found in a rat with IgAN of 40% alcohol ingestion for 12 weeks. In the rest of the alcoholic rats up to 8 weeks of 40% alcohol ingestion and 12 weeks of 10% alcohol ingestion no immunoglobulin deposition was observed but mild abuminuria(+1) and urinary protein 30 mg/dl to 100 mg/dl were found in two of these animals. In this experimental study of animal models, chronic alcohlo ingestion is clearly linked to renal disease even in the absence of liver cirrhosis. In alcoholic rats the mucosa of the small intestine revealed short and blunt villi with sloughing off of the surface epithelial cells and an increased infiltration of plasma cells in the lamina propria. It is assumed that the mucosal inflammation may result in disturbances of the intestinal immune barrier and then promotes abnormal absorption of macromolecules which stimulate plasma cells in the lamina propria to produce IgA. The small intestine of rats given 40% alcohlo for 8 weeks stained with FETC Goat Anti-rat IgA revealed an increased number of IgA positive cells, prrsumable plasma cells, in the lamina propria compared to that of the 10% alcohol group or the control rats on immunofluorescence microscopy. This fact suggests that an increased number of plasma cells pathologically responded to an abnormal alimentary antigen by the defense mechanism system and clearly participated in an excessive production adn secretion of IgA. These excessively produced IgA are combined with antigen of alimentary origin and produce IgA containing immune complexes which enter directly into the circulation resulting an elevated IgA immune complex in the blood. There will be more IgA present in the liver ; depending on the capacity of the liver to sequester or clear this increased supply, and elevated IgA immune complex levels occur in the circulation. In this study the liver revealed only a mild fatty change, which may render the saturation of Kupffer cells but there is no evidence of impairmint in the clearing function according to an ultrastructural base. In the clearance of IgA-containing immune complexes, the mononuclear phagocye system is important and an alcohol induced impaired hepatic immune complex clearance system might also contribute to an IgA increase . Therefore, the initiative of the pathogenesis of the alcohol induced IgAN is an alimentary antigen,abnormally absorbed by altered intestinal mucesa induced by alcohol. The first is a pathological response of plasma cells to the antigen enhancing synthesis of polymeric IgA which are combined with the antigen of alimentary origin and produce IgA containing immune complex. The second step is that these excessively produced IgA immune complexes enter directly into the circulation resulting in an elevated serum IgA immune complex which is eventually deposited in the mesangium of glomeruli. On the basis of this experimental study, it can be postulated that alcohlol induced IgAN explained by the mechanism of a possible immune complex-mediated disease.
Fe-Mn-Cr-Ni 계 오스테나이트 스테인리스강에서 질소의 용해거동
이희웅,김봉서,권해웅,김형걸,유경재 대한금속재료학회(대한금속학회) 1999 대한금속·재료학회지 Vol.37 No.2
Induction melting method under pressurized nitrogen gas was used to produce austenitic stainless steels dissolved with high content of nitrogen. Fe-Mn-Cr-Ni allay system was melted using Cr-nitride ferrous allay(6wt.% N) as a main additive element. The concentration and dissolution behaviors of nitrogen in as-casted alloys were investigated to clarify the effectiveness of induction melting method under pressurized nitrogen gas and Cr-nitride ferrous alloy in producing high nitrogen austenitic stainless steels having excellent mechanical, corrosion-resistance and non-magnetic properties. Nitrogen concentration in molten alloys was increased with increasing nitrogen pressure up to 1.5 atm. This result can be explained by Sievert's law. The nitrogen concentration of about 6.900 ppm was obtained in a molten alloy when melted at the nitrogen pressure of 1.5 atm. XRD and XPS measurements were carried out to investigate the dissolution behavior of nitrogen in a molten alloy. Although it was failed to detect some nitrides by XRD, XPS measurement revealed the existence of nitride such as Cr₂N. Therefore it can be concluded that the dissolved nitrogen in a molten alloy exists as two states, one is as a solid solution state, the other is as a nitride state. It seems reasonable to conclude the most of nitrogen were dissloved as a solid solution state, and some nitrogen are apt to be formed into a nitride.