http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
국내 유통 자외선 차단 기능성화장품 중 살균보존제 및 자외선차단성분 사용실태조사
박정희 ( Jeong Hee Park ),김종필 ( Jong Pil Kim ),김진아 ( Jin A Kim ),서계원 ( Kye Won Seo ),김은선 ( Eun Sun Kim ),서정미 ( Jumg Mi Seo ) 대한화장품학회 2017 대한화장품학회지 Vol.43 No.4
본 연구에서는 국내 유통 중인 자외선 차단 기능성화장품 총 100건을 대상으로 살균보존제 16종과 자외선차단성분 18종의 사용실태를 조사하였다. 그 결과, 검출률이 가장 높은 살균보존제 성분 5가지는 페녹시에탄올(61건), 안식향산(19건), 메틸파라벤(11건), 벤질알콜(8건), 프로필파라벤(7건)순이었으며, 자외선차단성분의 경우는 티타늄디옥사이드(81건), 에칠헥실메톡시신나메이트(69건), 징크옥사이드(48건), 에칠헥실살리실레이트(48건), 비스-에칠헥실옥시페놀메톡시페닐트리아진(44건)순이었다. 검사한 100건의 화장품 모두 검출된 살균보존제와 자외선차단성분 함량이 식품의약품안전처에서 정한 사용한도 기준에 적합하였지만 일부 자외선 차단 화장품의 경우 포장·용기에 표시되어 있지 않은 살균보존제와 자외선차단성분이 검출되었다. 100건 중 31건의 화장품에서 표시되지 않은 살균보존제 성분(벤질 알콜 등 6종)이 검출되었고, 2건에서는 표시되지 않은 자외선차단성분(호모살레이트 등 2종)이 검출되었다. This study was conducted to determine 16 preservatives and 18 UV filter ingredients levels in 100 sunblock products. The order of detection rates of preservatives was phenoxyethanol (n=61), benzoic acid (n=19), methyl paraben (n=11), benzyl alcohol (n=8), propyl paraben (n=7). Also the order of detection rates of UV filter ingredients was titanium dioxide (n=81), ethylhexyl methoxycinnamate (n=69), zinc oxide (n=48), ethylhexyl salicylate (n=48), bis-ethylhexyloxyphenol methoxyphenyltriazine (n=44). The content of the detected preservatives and UV filter ingredients was within maximum allowed amount established by KFDA. In addition, preservatives and UV filter ingredients, which were not labeled in the products, were detected in 31 and 2 products respectively.
Demodex canis 감염이 화학적으로 유발된 지연형 피부과민증에 미치는 영향
이채용,함현우,이정길,서계원,Lee, Chai-yong,Ham, Hyeon-woo,Lee, Chung-gil,Seo, Kye-won 대한수의학회 1995 大韓獸醫學會誌 Vol.35 No.4
To observe the effect of Demodex canis infection on the cellular immune response and hematological profile, 8 Doberman pinschers experimentally infected with D cains and 4 uninfected control dogs were sensitized with 2, 4-dinitro-chlorobenzene(DNCB) on the skin and were challenged with DNCB 14 days after the initial sensitization to elicit allergic contact dermatitis. Histological and hematological changes of these dogs were then observed. Macroscopic changes of skin challenged with DNCB in D canis-infected dogs included significantly reduced area of allergic reaction(p<0.05) than in uninfected control group. Infiltration of inflammatory cells in the D canis-infected group was also significantly reduced(p<0.05) than in the uninfected control group. These changes indicated that the cell-mediated immune response of the animals was suppressed by the infection with D canis. Total white blood cell count in dogs infected with D canis was increased when dogs were sensitized with DNCB (p<0.01). The result appeared to be caused by stress due to D canis infection, secondary bacterial infection and decreased efficacy of general body defense system. Blood eosionophils were increased in D canis-infected dogs which appreared to be caused by the allergic contact dermatitis. Blood chemistry analysis revealed that total protein and globulin were increased(p<0.05), while albumin level was decreased. This result appeared to be caused by secondary bacterial infection.
이윤국(Youn-Goog Lee),김난희(Nan-Hee Kim),최영섭(Young-Seop Choi),김선정(Sun-Jung Kim),박주현(Ju-Hyun Park),강유미(Yu-Mi Kang),배석진(Seok-Jin Bae),서계원(Kye-Won Seo),김종민(Jong-Min Kim) 한국환경보건학회 2020 한국환경보건학회지 Vol.46 No.2
Objective: This study is designed to measure the concentration of DBPs (disinfection by-products) in pool water and in air and to estimate the carcinogenic potential through the evaluation of inhalation exposure. Methods: The subjects were six indoor swimming pools with many users in Gwangju. Samples of pool water and indoor air were taken every one month from August 2018 to August 2019 and analyzed for eight swimming pool standards. Three-liter air samples were collected and the VOCs were analyzed using GC/MS directly connected to thermal desorption. Results: pH was 6.8-7.5 and the concentration of free residual chlorine in pool water was 0.40-0.96 ?/ℓ. Physicochemical test items such as KMnO₄ consumption and heavy metal items such as Aluminum met existing pool hygiene standards. No VOC materials were detected except for the DBPs. The concentration of THMs in the pool water was 11.05-41.77 µg/L and the THMs mainly consist of Chloroform (63-97%) and BDCM (3- 31%). The concentration of indoor air THMs is 13.24-32.48 µg/m3 and consists of Chloroform. The results of carcinogenic assessment of chloroform in the indoor swimming pool via inhalation exposure were 2.0 to 6.4 times higher than the ‘acceptable risk level’ suggested by the US EPA. Conclusions: The concentration of THMs in the pool water is 11.05-41.77 µg/L, most of which is chloroform. In addition, the concentration of indoor air THMs is 13.24-32.48 µg/㎥ . The result of carcinogenic assessment of chloroform was 2.0 to 6.4 times higher than the ‘acceptable risk level’ suggested by the US EPA.
작두콩의 메탄올 추출물로부터 항산화 활성 화합물의 분리 및 동정
김종필(Jong-Pil Kim),이향희(Hyang-Hee Lee),문제학(Jae-Hak Moon),하동룡(Dong-Ryong Ha),김은선(Eun-Sun Kim),김진환(Jin-Hwan Kim),서계원(Kye-Won Seo*) 한국식품과학회 2013 한국식품과학회지 Vol.45 No.6
본 연구는 항산화 활성이 뛰어난 작두콩의 메탄올 추출물을 대상으로 극성차를 이용한 용매분획을 행하여 n-hexane층, CHCl3층, EtOAc층, butanol층, 그리고 H2O층을 얻었다. 그중 활성이 가장 높은 EtOAc층을 대상으로 silica gel column chromatography 및 HPLC를 행하여 4종의 활성 화합물을 분리하고, MS 및 NMR 분석을 통하여 구조해석을 행하였다. 그 결과 화합물 1-4는 methyl 3,4,5-trihydroxybenzoate (methyl gallate, 화합물 1), 3,4,5-trihydroxybenzoic acid (gallic acid, 화합물 2), 1,6-di-O-galloyl β-Dglucopyranoside (화합물 3), 그리고 1,4,6-tri-O-galloyl β-D-glucopyranoside (화합물 4)로 각각 동정되었다. 그리고 분리 화합물들의 DPPH radical-scavenging 활성은 화합물 4>화합물 3>화합물 2>화합물 1 순으로 평가되었다. 또 분리된 양을 기준으로 하였을 때, 화합물 1과 2는 작두콩 중에 다른 화합물들에 비해 다량으로 존재해있을 것으로 시사되었으며, 이들 화합물이 작두콩의 항산화 활성에 상당부분 기여하고 있는 것으로 판단되었다. 또한 화합물 4는 본 연구를 통해 작두콩으로부터는 처음 분리·동정되었다. The ethyl acetate (EtOAc) layer of Canavalia gladiata (sword bean) methanol extracts showed higher 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity than other layers. Four phenolic compounds were isolated from the EtOAc layer by silica gel column chromatography and prep-HPLC using a guided DPPH radical-scavenging assay. The isolated compounds were identified as methyl gallate (1), gallic acid (2), 1,6-di-O-galloyl β-D-glucopyranoside (3), and 1,4,6-tri-O-galloyl β-D-glucopyranoside (4) based on MS and NMR analyses. Among the four compounds, no. 4 was isolated from this plant for the first time. Their DPPH radical-scavenging activities based on SC50 decreased in the following order: 4 (6.9 μM)>3 (8.3 μM)>2 (10.0 μM)>1 (10.3 μM).