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박하 ( Mentha piperita ) 세포 현탁배양에서 멘톨생합성 경로
박시형(Si Hyung Park),채영암(Young Am Chae),이형주(Hyong Joo Lee),김수언(Soo Un Kim) 한국응용생명화학회 1993 Applied Biological Chemistry (Appl Biol Chem) Vol.36 No.5
The metabolic capability of the cultured cells of peppermint was tested with whole intact cells by feeding appropriate exogenous substrates to the suspension cultures. Conversion of (-)-limonene into any other monoterpenes was not observed with the suspension cultures. (+)-Pulegone was converted into (+)-isomenthone and (-)-menthone, and (-)-menthone into (-)-menthol. The experiments confirmed that the suspension retained most of the menthol biosynthesis pathway in the cell except for a few loci. (-)-Isopiperitenone was transformed into (+)-pulegone, piperitenone, (-)-7-hydroxyisopiperitenone and two unidentified products.
박시형(Si Hyung Park),정효상(Hyo Sang Jung),유태열(Tae Yol Yoo),이성수(Seaung Soo Lee) 한국자동차공학회 2001 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2001 No.5_2
Motorcycle industry, for its competitive position, depends on part design technology. This part design has a bulky amount of data and asks the accumulation of advanced technical skill and experience, and fragmentary technical application is not enough to get to the kernel of a problem.<br/> Therefore, the improvement of proper productivity - the starting point of engineering design and useful Design Methodology for products manufacturing are needed.<br/> Thus this paper is aimed to create a program that outputs dynamic characteristics of a vehicle when the data from fully understanding on motorcycle's brake system and induced fornmla for brake design are inputted.<br/>
증례 : 신장 ; 관상동맥 성형술 시행한 환자에서 Clopidogrel과 관련된 용혈성 요독증후군
박시형 ( Si Hyung Park ),박진한 ( Jin Han Park ),박상율 ( Sang Yool Park ),이은지 ( Eun Ji Lee ),전현수 ( Hyun Soo Jun ),김영훈 ( Yeong Hoon Kim ),김양욱 ( Yang Wook Kim ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2S
Clopidogrel은 항혈소판제로 여러 임상영역에서 사용된다. 기존의 약제보다 부작용도 적어 안전하게 널리 쓸 수 있는 이 약제가 드물게는 이와 같은 심각한 합병증을 유발할 수 있다. 이에 우리는 이러한 합병증을 이해하고 주의 해야 한다. 저자들은 급성 관상동맥 증후군이 있었던 47세 남자 환자에서 이와 같은 합병증을 경험하였고, 약물 중단 및 치료적 혈장분리술 등으로 호전되었던 증례를 1예 경험하였기에 문헌고찰과 함께 보고하는 바이다. Thienopyridines are antiplatelet agents used in post-percutaneous coronary angioplasty patients and patients with acute coronary syndrome, stroke, and peripheral arterial disease. Ticlopidine has been shown to reduce the incidence of stent thrombosis, but it may also cause serious hematological side effects. Among the thienopyridines, clopidogrel is considered to be a safe alternative to ticlopidine because of its decreased incidence of hematological adverse effects. However, some hematological side effects can occur and may be fatal. In this case, a 47-year-old man complained of dyspnea and generalized edema. He had been taking clopidogrel after coronary angioplasty. His laboratory findings showed acute renal failure, microangiopathic hemolytic anemia, and thrombocytopenia, which were consistent with hemolytic uremic syndrome (HUS). After discontinuing clopidogrel and undergoing plasma exchange, he recovered fully. To our knowledge, this is the first reported case of clopidogrel-induced HUS in Korea. (Korean J Med 2011;80:S253-S257)
김시은,박봉수,박시형,신경진,하삼열,박진세,박강민,Kim, Si Eun,Park, Bong Soo,Park, Si Hyung,Shin, Kyong Jin,Ha, Sam Yeol,Park, Jin Se,Park, Kang Min The Korean Society of Clinical Neurophysiology 2015 Annals of Clinical Neurophysiology Vol.17 No.2
Background: The aim of this study was to investigate the predictive value of snoring frequency in the diagnosis and severity of obstructive sleep apnea. Methods: Patients who underwent polysomnography with one or more of the following characteristics were included: 1) sleepiness, non-restorative sleep, fatigue, or insomnia symptoms; 2) arousal due to cessation of breathing or the occurrence of gasping or choking when waking up; and 3) habitual snoring, breathing interruptions, or both, noted by a bed partner or other observer. We analyzed the differences in clinical and polysomnographic variables between patients with and without obstructive sleep apnea and investigated the associations of those variables with obstructive sleep apnea severity. Results: One hundred ninety-three patients met the inclusion criteria, and 145 of the 193 patients were diagnosed with obstructive sleep apnea. Multiple logistic regression analysis showed that large neck circumference (p = 0.0054) and high snoring index (p = 0.0119) were independent predictors for obstructive sleep apnea. Moreover, between the obstructive sleep apnea severity groups, there was a strong tendency of difference in body mass index (p = 0.0441) and neck circumference (p = 0.0846). However, there was no significant difference in snoring frequency according to obstructive sleep apnea severity (p = 0.4914). Conclusions: We confirmed that snoring frequency is a predictor of obstructive sleep apnea. In addition, we showed for the first time that snoring frequency is not associated with obstructive sleep apnea severity, thus it is not a valuable marker for predicting obstructive sleep apnea severity.