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연구논문 : 의약화학 ; 2,4,6-치환 피리딘 유도체의 합성, topoisomerase 1 억제능 및 구조-활성 관계 연구
조룡현 ( Long Xuan Zhao ),문윤수 ( Yoon Soo Moon ),알준바스넷 ( Arjun Basnet ),김은경 ( Eun Kyung Kim ),장영동 ( Yurng Dong Jahng ),박재규 ( Jae Gyu Park ),정태천 ( Tae Cheon Jeong ),조원제 ( Won Jea Cho ),최상운 ( Sang Un Choi ) 영남대학교 약품개발연구소 2004 영남대학교 약품개발연구소 연구업적집 Vol.14 No.-
박종명(Jong Myeong Park),문윤수(Yun Su Mun),김창남(Chang-Nam Kim),장제호(Je Ho Jang),권오상(Oh Sang Kwon),이문수(Moon Soo Lee),강윤중(Yoon Jung Kang),박주승(Joo Seung Park) 대한종양외과학회 2013 Korean Journal of Clinical Oncology Vol.9 No.2
Purpose: Lymph node metastasis is a stage-determining factor and the most important prognostic factor for colon cancer patients. We aimed to verify the influence of the aspects of lymph node metastatic level on the prognosis of the stage III colon cancer patients. Methods: We studied the survival rate of ninety-eight patients with stage III colon cancer who underwent an open and laparoscopic surgery at Eulji University Hospital from November 1998 to December 2009. We evaluated the survival rate and prognostic factors including the level of positive lymph node and additional factors. The level of positive lymph node was classified as either level I (pericolic and intermediate lymph node metastasis) or level II (apical lymph node metastasis). Results: The average age of the patients was 62.7 years (range, 30 to 89 years) old and the mean follow-up period was 45.9 months (range, 2 to 129 months). The comparison of the survival rates based on the level of lymph nodes shows that level I was 89.5% while level II was 41.7% (P=0.002). Multivariate analysis showed that level of positive lymph node was a significant prognostic factor. Conclusion: In this study, the level of lymph node metastasis in stage III colon cancer was significant prognostic factor. Therefore, exact evaluation and further treatment plans should be determined based on clear analysis of various aspects of the lymph nodes acquired by accurate and meticulous surgery.
연구논문 : 의약화학 ; COX 및 5-LOX에 대한 이중 억제 활성을 갖는 프로페논 모핵의 간단한 방향족 화합물의 합성
장영동 ( Yurng Dong Jahng ),조룡현 ( Long Xuan Zhao ),문윤수 ( Yoon Soo Moon ),알준바스넷 ( Arjun Basnet ),김은경 ( Eun Kyung Kim ),장현욱 ( Hyeun Wook Chang ),주혜경 ( Hye Kyung Ju ),정태천 ( Tae Cheon Jeong ),이응석 ( Eung Seok 영남대학교 약품개발연구소 2004 영남대학교 약품개발연구소 연구업적집 Vol.14 No.-
Synthesis, Characterization and in Vitro Identification of N^7-Guanine Adduct of 2-Bromopropane
Zhao, Long-Xuan,Kim, Eun-Kyung,Lim, Hyun-Tae,Moon, Yoon-Soo,Kim, Nam-Hee,Kim, Tae-Hyung,Choi, Heesung,Chae, Whigun,Jeong, Tae Cheon,Lee, Eung-Seok 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Recently, we have reported that 2-bromopropane might have an immunotoxic potential in rats when exposed for 28 days. In the present studies, the possibility of 2i-deoxyguanosine adduct formation by 2-bromopropane was investigated in vitro to elucidate molecular mechanism of 2-bromopropane-induced immunosuppression. N^7-Guanine adduct of 2'-bromopropane (i.e., N^7-isopropyl guanine) was chemically synthesized and structurally characlerized by analysis of UV, ^H-NMR, ^12C-NMR, COSY and fast atom bombardment, mass spectrometry to use as a reference material. Incubation of 2'-deoxyguanosine with an excess amount of 2-bromopropane in PBS buffer solution, pH 7.4, AT 37℃ for 16 h, followed by a thermal hydrolysis, produced a detectable amount of N^7-isopropyl guanine by an HPLC and UV analysis. The present results suggest that 2-bromopropane might form a DNA adduct in N^7 position of 2'-deoxyguanosine at a physiological condition.