여드름 환자의 혈중 Testosterone 및 Dehydroepiandrosterone - sulfate 농도에 관한 연구

김낙인(Nack In Kim),오희수(Hee Soo Oh),이상수(Sang Soo Lee),이무형(Moo Hyung Lee),허충림(Choong Rim Haw) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.1

This study was performed to detect the hormonal abnormalities and to investigate the relationship between the levels of plasma testosterone and DHEA-S in 21 female patients with acne vulgaris using radioimmunoassay. The results were as follows : 1. The levels of plasma testosterone in patients group and control group(n=9) were 352+11.8 ng/dl, 223+ 9.7 ng/dl, respectively, and significantly elevated in patient group(p < 0.01), 2. The levels of plasma DHEA-S in patient group and control group were 286.6+ 126.8 pg/dl, 238.6+60.0 pg/dl, respectively, and did not show statistical significance. 3. The levels of plasma testosterones in patient subgroups classified by modified Pillsbury method were as follows minor group 32.6+5.3 ng/dl, mild group 33.4+15,5 ng/dl, moderate group 39.6+12.6 ng/dl. The testosterone levels in all the subgroups increased significantly than those in control group(352-t11.8 ng/dl) (p<0.05, p<0.05 p < 0.01) 4. The levels of plasrna DHEA-S in patient subgroups were follows minor group 242.5+412 pg/dl, mild group 263.9+166.1 pg/dl, moderate group 353.4+-1273 pg/dl. The DE3EA-S levels in moderate group increased significantly than those in cotrol (238,6+60,0 pg/dl) and minor group(p<0.05). 5. There was no correlation between the plasma testosterone levels and the plasma DHEA-S levels in the acne patients.

건선에서의 보습제

김낙인 ( Nack In Kim ) 한국피부장벽학회 2007 한국피부장벽학회지 Vol.9 No.1

Psoriasis is an inflammatory skin disease that commonly causes itching and scaling. Because of its chronic and recurring nature, psoriasis can affect a person`s quality of life. In this lecture, we will see the effects of psoriasis on skin, especially on skin dryness. The decision to employ a particular treatment is based on the type of psoriasis, its location, extent, severity, and the age and gender of the patients. There can be variations between individuals in the effectiveness of specific psoriasis treatments such as topical, systemic treatment and phototherapy. Among the topical treatments for psoriasis, the most important and basic consideration is use of a skin moisturizer. These products produce an occlusive film that limits evaporation of water from the skin and allows the stratum corneum to rehydrate itself. Hydration of the stratum corneum can also lead to enhanced delivery of other medications, such as corticosteroids. In psoriatic skin lesions, it is well established that the transepidermal water loss (TEWL) values increase and decrease when a moisturizer is applied, so these values have also been used to monitor the efficacy of active treatments for psoriasis. Because dryness in psoriasis is the principal cause for increased severity, using the proper moisturizer is necessary and beneficial for patients suffering with psoriasis.

청피반성 혈관염의 임상 및 병리조직학적 고찰

백성호(Sung Ho Baek),김낙인(Nack In Kim),허충림(Choong Rim Haw) 대한피부과학회 1994 大韓皮膚科學會誌 Vol.32 No.2

Background : Livedo vasculitis shows variable clinical and histopathologic features according to its courses. There are also some discrepancies in histopathologic findings between the authors. Objective : Our purpose is to clarify the clinical and istopathologic feat tures of livedo vasculitis. Methods : We reviewed the clinical and histopathologic features in cluding direct immunofluorescence study and response to treigtment in eight patients with livedo vasalitis. Results : The ratio of males to females was 1:3 with female predusm nance. Age of onset was predominant, in young to middle-age, ranging from 19 to 64 years old. In seven patients skin lesions were aggravated during the summe, and in one patient during the winer. All patients had purpuric or telangiectatic lesions on the lower extremities. Painful ulcers developed in seven patients and some of the ulcers healed with whitish atrophic scars. Five patients had preceeding livedo reticularis. One patient had Raynauds phenomenoin and the other patients did not show alinormal findings related to the systemic diseases. Histopathologically, in two patients fibrinoid materi.il was deposited in the vessel walls mildly, and in six patients obviously with partial to complete obst,r iction of blood vessels. Extravasation of RBCs and thrombus formation were found clearly in seven patients, but in one patient these findings were observed in a mild degree. Endothelial swellings were obserrved in all patients. Perivascular infiltrations of mononuclear cells were also observed in all patients in various degrees. But only two patients with secondary bacterial infection showed neutrophil infilt ations or nuclear dusts. So, histopathologic findings are corripatible with lymphocytic vasculitis. The locations of predominantly affected vessels were variable. Direct immunofluorescence studies were done in six patients. Four of these patients showed positive findings. At least 4 months were needed for the complete healing of the skin lesions. Conclusion : Livedo vasculitis is chronic vasculit is aggravated in mostly summer. Most of the initial purpuric lesions progress to ulcers which is healed with whitish atrophic scars. Histopathoiogic findings suggest livedo vasculitis is a sort of lymphocytic vasculitis. (Kor J Dermatol 1994; 32(2): 245-252)

정상인 및 나환자 표피 각질층의 수분 함량에 관한 연구

심우영(Woo Young Sim),김낙인(Nack In Kim),허충림(Choong Rim Haw),임수덕(Soo Duk Lim) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.5

We evaluate the water content, hygroscopicity and water holding capacity in 40 healthy individuals and 17 leprosy patients by skin surface hydrometer(IBS Inc, Japan), and the correlation between the nerve destruction and the hydration state. In Eiealthy individuals the measuring sites were the flexor and extensor surfaces of the arm, forearm, thigh and leg, In leprosy patients we measured on the extensor surface of forearm with shows abnormal sensation, and opposite ar neighboring skin which shows normal sensation. The results are as follows: 1. The water content of healthy individuals is highest in the flexor surface af arm (49. 50 + 18.38ug ) and lowest in the extensor surface of leg(30.75 -12.09ug) 2. The hygrosccpicity of healthy individuals is highest in the flexor surface of arm(296. 30 + 70.75ug ) and lowest in the extensor surface of leg(24$. Q7+5) 5ppg) 3. The water content of the extensor surface of lorearm in leprosy patients, which .hows abnormal sensation, is decreased(16. 35 +20. 82 ug) and it is statisti calli significant when compared with healthy individuals(p<0.005). 4. The hygroscopicity of the extensor surface of forearm in leprosy patients. which shows abnormal sensation, is decreased(94. 29 + 71. 62 ug) and it is statistically significant when compared with opposite or neiphboring skin and healthy individuals(p<0. 005)

방사선 조사가 배양된 인체 각질형성세포 및 멜라닌세포에 미치는 영향

유한동(Han Dong Yoo),김낙인(Nack In Kim),박재경(Jai Kyung Park),홍성언(Seong Eon Hong),허충림(Choong Rim Haw) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.4

Background : Radiation has been used in t,he medical field of dragnosis and treatment. There is widely used ionizing radiat:ion such as naturally occuring r-rays or machine-made X-ray. This radiation is able to induce the structural and functional alterations of the mammalian cells. But we have few detailed reports on the effects of radiation on epidermal cells and their immune functions. Objective : This study was performed to investigate the effect of radiation on cultured human keratinocytes and melanocytes. Materials and Methods : Cultured human keratinocytes and melanocytes were irradiated with 2,6, l0Gy from a Co saurce and stimulated by 100 U/ml of ekratinocyte immediately after irradiation. We investigated cell numbers and morphological changes, DNA synthesis and HLA-DR antigen expression. Results : After exposure to r-ray, the proliferation of keratinocytes and melanocytes decreased in a time and dose dependent fashion to each control group. Tliey showed decreased density, a larger size and a round appearance after radiation exposure and an especially shortened and decreased number of dendrites in the melanocytes. In DNA synthesis counted using [H]-thymidine incorporation, the keratinocvtes decreased values in a dose depen(lent manner at 24 and 72 hours after irradiation but no differense was observed at 168 hours. In melanocytes, there was a greater decrease than that of keratinocytes. The melanin content/cell in all radiation exposed groups increased in a time and dose dependent fashion t,o each contr ol group. HLA-DR antigen expression on keratinocytes after radiat,ion exposure decreased to the control group, but there were no significant differences acccirding to the dose of radiation, And there were no significant diifferences of HLA-DR antigen expression on the melanocytes betweer. controls and the radiation exposed groups. Conclusion : Antiproliferative activity was dependent on the exposure time and dose of r-ray exposure. According to the time after radiation exposure, melanogenic activity was stimulated. The expression of HLA-DR, antigen decreased in keratinocyte after radiation exposure but there was no decrease in melanocytes. (Kor J Dermatol 1994:32(4); 609-619)

한국 청소년에서의 Piezogenic papules에 대한 임상적 고찰

이승한,이무형,심우영,김낙인,허충림 ( Seung Han Lee,Mu Hyoung Lee,Woo Young Sim,Nack In Kim,Choong Rim Haw ) 대한피부과학회 1991 大韓皮膚科學會誌 Vol.29 No.5

N/A A Clinical Study of Piezogenic Papules in Korean Youth Seung Han Lee, M.D., Mu Hyoung Lee, M.D., Woo Young Sim, M.D., Nack In Kim, M.D., Choong Rim Haw, M.D. Department of Dermatology, College of Medicine, Kyung Hee University Seoul, Korea We investigated the prevalence, distribution, the number and size of the piezogenic papules in a student population, aged 15 to 25 years old. The results were as follows ; 1. The prevalence was 7.4%(86 cases/1167 students in total). 2. The prevalence in male was 4.6% (43/944), and that in female was 19.3%(43/223)(P<0.001). 3. The number of patients who had piezogenic papules on one foot was 48(55.8%), and those who had lesions bilaterally was 38(45.2%), Lesions of the left foot were more common than right. The medial aspect of the heel was 6 to 10 times a more common location compared to the lateral or posterior aspect(P<0.05). 4. The average number of lesions was 4.5 and there was no significant difference between male and female, and right and left foot. The number of papules on the medial aspect of the heel was 3 times more than that of the lateral, or posterior aspect(P<0.05). 5. The average size of lesions is 4㎜ in diameter(2㎜-10㎜), and of the patients were asymptomatic. 6. The average body weight of patients, 64.5±8.5kg in the male and 55.5±8.8kg in the female, was greater than those of the control group, 62.9±8.5kg and 52.5±5.0kg, respectively, but there was no statistically significant differenceir=0.150).

건선의 초기 병변과 만성 병변에서의 침윤세포 성상에 관한 면역조직화학적 연구

조항래,심우영,양문호,김낙인 ( Hang Rae Cho,Woo Young Sim,Moon Ho Yang,Nack In Kim ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.1

Backgrou~nd: Psoriasis is a chronic relapsing disease characterized by epidermal hyperproliferation and epiderrnal and dermal inflammatory cell infiltrat,ion. The etiology of this disease is still unclear. Recently, there has been growing interest in the probable role of a T cell mediated immune response in the pathogetiesis of psoriasis. The infiltrating cells in psoriatic lesions have been iden- tified by monoclonal ant~ibodies and T cells were found to be the major infiltrating type. Objective : This stud was done to investigate the difference of cellular infiltration and adhesion molecule exg!ressions between early and late skin lesions of psoriasis using immunohistochernical studies. Methpds : Patients with psoriatic lesions were divided into two groups. The early gr oup were defined as having skin l~i:sions that had lasted for about 4 weeks, and late group were defined as having skin lesions that had lasted for more than 8 weeks. Then biopsy specirnens were stained using monoclonal antibidies for CD4, CD8, CD1, LFA-1, and ICAM l. Results : 1. CD4 positive cells,vere tly increased in both the early and late groups compared with CD8 positive cells. Z. CD8 positive cells were significantly increased in the late g~roup compared with the early group. 3. CDl-posit,ive dendri!ic cells were more nurnerous in the late group than the early group. 4. There were no significant differences between the early and late group with regard to numbers of LFA-1 positive (ells. 5. ICAM-1 were more strongly expressed on epidermal keratinocytes in the late than the early group. Conclusion : CD4-positive cells are important in early and late psoriatic lesions and CD8 positive cells playi more important role in late than early lesions. ICAM-1 and LI'A-1 play a role in cell adhesion of infiltrating cells and lymphocytic rnigration to the epidermis. (Kor J Dermatol 1997;3~5(1): 49-56)

원형 탈모증 환자의 말초혈액내 면역세포의 변화에 관한 연구

임성춘(Sung Choon Lim),김낙인(Nack In Kim),허충림(Choong Rim Haw) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.1

Authors have quantitated the T cell and T subsets(T and T cell) in the per- ipheral blood of 16 patients with alopecia areata and 16 normal healthy controls. The results are as follows: 1. The mean values of the T cell in total patient group(54,6+7.9g) and AAP group(5,3. 1+8. 1%) showed staticstially significant decrease when it compared with the mean value of the control group(64.6+3.6%) respectively(p<0.005). In ATU group the mean value of the T cell(53. 1+8. 1%) also showed decreasing tendency in comparison with that of control. The mean values of the T cell in total patient group(30.9+8. 9%) RIld AAP group(3'l. 5+8. %) showed statistically significant decrease when it compared with the mean value of the control group(42,6+8.9%) respectively(p<0. 005). In ATU group the mean value of the T< cell(28. 7+10. 9%) also showed decreasing tende- ncy in comparison with that of control. 3. The mean values of the Tr, cell in total patient group(6. 1+2. 2%) and AAP group(5.9+2.4%) showed staticstially significant decrease when it compared with the mean value of the control group(7.9+1.3%) respectively(p(p pl, pgp p25) In ATU group the mean value of the T cell(6. 7+0. 9%) also showed decreasing tendency in comparison with that of control. 4. The mean values of the T/T ratio showed no significant difference between the patient groups(total, AAP, ATU) and control group, respectively. Above data showed that defect of T cell and T subsets may be associated with the pathogenesis of alopecia areata.

한국인 건선환자에서 발병하는 질환에 대한 연구 - 다기관 연구

김광호(Kwang Ho Kim),전현진(Hyun Jin Jeon),김광중(Kwang Joong Kim),윤재일(Jai Il Youn),김낙인(Nack In Kim),김태윤(Tae Yoon Kim),최지호(Jee Ho Choi),박기범(Ki Beom Park) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.7

N/A Background: The prevalence of other diseases associated with psoriasis has been investigated in recent years. Objective: This study was performed to see diseases associated with psoriasis in Korea. Methods: From September 1999 to May 2000, a total of 293 patients with psoriasis, who visited the department of dermatology in 6 hospitals, were enrolled in a subject group for the study. We surveyed the incidence rates of associated diseases. Results: In our study, diseases more concomitantly present in patients with psoriasis were dermatophyte infection, seborrhea dermatitis and benign tumor & nevus in skin diseases and obesity, diabetes mellitus, hypertension, gastritis and hepatitis in systemic diseases. Less concomitantly present in-patients with psoriasis were erythroderma, acne, contact dermatitis, atomic dermatitis, bacterial infection, tonsillitis, and internal cancer. Conclusion: Our observations show a distinct pattern of diseases associated with psoriasis in Korea. Further investigation will be mandatory to elucidate concomitant diseases in psoriasis. (Korean J Dermatol 2001;39 (7): 743~748)

모발로 분화하는 종양에 대한 임상 및 병리조직학적 소견 -대한피부과학회 피부병리 연구분과위원회 공동연구-

김유찬 ( You-Chan Kim ),강원형 ( Won-Hyoung Kang ),고재경 ( Jai-Kyoung Koh ),김낙인 ( Nack-In Kim ),김방순 ( Bang-Soon Kim ),김상원 ( Sang-Won Kim ),김수남 ( Soo-Nam Kim ),김수찬 ( Soo-Chan Kim ),노영석 ( Young-Suck Ro ),명기범 ( 대한피부과학회 2003 대한피부과학회지 Vol.41 No.9

Background : Data on the clinicopathologic features of hair follicle tumors in Korea are limited. Objective : The purpose was to investigate the clinical and histopathologic characteristics of hair follicle tumors in Korea. Methods : Two hundred sixty four cases of hair follicle tumors seen from 1999 to 2001 in Korea were analyzed clinically and histopathologically. Results and Conclusion : 1. The most common hair follicle tumor in Korea was pilomatricoma(81.0%), followed by trichoepithelioma(6.4%), dilated pore of Winer(3.8%), and proliferating trichilemmal tumor(2.2%). 2. Hair follicle tumors usually occurred as a solitary skin-colored nodule. The most commonly involved site was the face, and the peak age of presentation was 10 to 19. 3. Pilomatricoma usually occurred as a solitary skin-colored nodule. The most commonly involved site was the arm, and more than 50% of tumors occurred before the age of 20. Histopathologically, the tumor was often surrounded by fibrous capsule and was composed of basophilic and shadow cells. It was usually located in the dermis and extended into the subcutis. Retraction spaces between tumor nests and stroma were frequently observed. 4. Trichoepithelioma usually occurred as multiple skin-colored papules on the face. Histopathologically, the tumor was usually located in the dermis with sometimes connected to the epidermis. It frequently showed peripheral palisading. 5. Dilated pore of Winer usually occurred as a solitary brownish to pigmented papule on the face in middle-aged persons. 6. Proliferating trichilemmal tumor occurred as a solitary or multiple tumors. Histopathologically, the tumor was usually surrounded by incomplete fibrous capsule. Tumor cells frequently showed clear cell formation, nuclear atypia, mitosis, peripheral palisading, trichilemmal keratinization, and individual keratinization. (Korean J Dermatol 2003;41(9) : 1177~1186)