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고콜레스테롤식이가 Wister계와 자생고혈압 흰쥐에서 대동경맥화 초기변화에 미치는 영향
장운하,유재형,송계용,류왕성,유언호 중앙대학교 의과대학 의과학연구소 1993 中央醫大誌 Vol.18 No.2
Atherosclerosis refers to a group of disorders that have common thickening and loss of elasticity of arterial walls. Of the various risk factors, hyperlipidemia and hypertension are most important. So, the scanning electron microscopic observation was carried out to evaluate the effects of high cholesterol diet on the early altheroscleotic changes of the aorta both in Wistar and spontaneously hypertensive rat(SHR) for a 8 months. The blood pressure of SHR rised gradually from 3.5months after birth and reached nearly 190 mmHg from the 5.5 to 9.5months. blood cholesterol levels were remarkably increased in rats fed high cholesterol diet from 67.0+-㎎/㎗ to 403.0+-43.8㎎/㎗ in Wistar rat and 117.80+-36.00㎎/㎗ in SHR, respectively. Until 3.5 months, adhesion of a few platelets and fibrin were noted in Wister rats fed with hypercholesterol diet while focal injury on the endothelial surface were noted in SHR in 3.5 months. Later on, adhesion of platelets, fibrin and white blood cells as well as demage of inner wall revealed as multiple small holes wer more marked, resulted in marked atherosclerosis at 9.5month. Atherosclerotic changes were more marked in the condition of hypertension with hypercholesterolemia. With above results, it is suggested that hypercholesterolemia induce endothelial damage by adhesion of platelets and white blood cells in SHR at the beginning of the atherogenesis.