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Application of contrast-enhanced ultrasound for evaluation of thyroid nodules
Jia Zhan,Hong Ding 대한초음파의학회 2018 ULTRASONOGRAPHY Vol.37 No.4
Contrast-enhanced ultrasound (CEUS) is widely used to evaluate tumor microcirculation, whichis useful in the differential diagnosis between benignity and malignancy. In the last 10 years, theapplicability of CEUS to thyroid nodules has greatly improved due to technological refinementsand the development of second-generation contrast agents. In this review, we summarize theapplications of CEUS for thyroid nodules, focusing on the imaging findings of malignant andbenign nodules in the existing literature and the use of those findings to predict malignancies,with an additional brief description of the utilization of CEUS for other thyroid-related diseases.
Jia-Xiang Lin,Yong-Jian Cai,Ze-Ming Yang,Shu-Hua Xiao,Zhan-Biao Chen 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.45 No.1
Steel fiber composite bar (SFCB) is a novel type of reinforcement, which has good ductility and durability performance. Due to the unique pseudo strain hardening tensile behavior of SFCB, different flexural behavior is expected of SFCB reinforced concrete (SFCB-RC) beams from traditional steel bar reinforced concrete (S-RC) beams and FRP bar reinforced concrete (F-RC) beams. To investigate the flexural behavior of SFCB-RC beam, four points bending tests were carried out and different flexural behaviors between S/F/SFCB-RC beams were discussed. An flexural analytical model of SFCB-RC beams is proposed and proved by the current and existing experimental results. Based on the proposed model, the influence of the fiber volume ratio R of the SFCB on the flexural behavior of SFCB-RC beams is discussed. The results show that the proposed model is effective for all S/F/SFCB-RC flexural members. Fiber volume ratio R is a key parameter affecting the flexural behavior of SFCB-RC. By controlling the fiber volume ratio of SFCB reinforcements, the flexural behavior of the SFCB-RC flexural members such as bearing capacity, bending stiffness, ductility and repairability of SFCB-RC structures can be designed.
Effect of External Heat Input on Fluid Sloshing Dynamic Performance in a Liquid Oxygen Tank
Liu Zhan,Feng Yuyang,Liu Yuanliang,Yan Jia,Li Yanzhong 한국항공우주학회 2020 International Journal of Aeronautical and Space Sc Vol.21 No.4
In the present study, a numerical model is developed to research the effect of the heat input on fluid sloshing. The volume of fluid method is used to simulate fluid reciprocating motion during sloshing with the mesh motion treatment being coupled. The external sloshing excitation is realized by user-defined functions and the convection thermal boundary condition is adopted to consider the heat exchange between the tank and the external environment. The model validation is made with the relative error being less than five percent. Based on the developed numerical model, the variation of fluid pressure, interface fluctuation, fluid sloshing hydrodynamics and fluid temperature distribution are, respectively, analyzed. Some conclusions are obtained finally. The present study is significant to the fluid sloshing suppression in cryogenic fuel storage tanks.
Liu, Jia,Ge, Yang-Yang,Zhu, Hong-Cheng,Yang, Xi,Cai, Jing,Zhang, Chi,Lu, Jing,Zhan, Liang-Liang,Qin, Qin,Yang, Yan,Yang, Yue-Hua,Zhang, Hao,Chen, Xiao-Chen,Liu, Zhe-Ming,Ma, Jian-Xin,Cheng, Hong-Yan,S Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected to ionizing radiation (IR), in the presence or absence of fenofibrate treatment. Cell growth and survival, apoptosis and cell cycle were evaluated. In addition, CNE-2 cells were xenografted into nude mice and subjected to IR and/or fenofibrate treatment. The expression of cyclinB and CDK1 was detected by Western blotting. Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex. These data suggest that fenofibrate could be a promising radiosensitizer for HNSCC radiotherapy.
Shengpeng Zhan,Ruize Li,Tian Yang,Dan Jia,Jiesong Tu,Lixin Ma,Bingxue Cheng,Haitao Duan 한국고분자학회 2023 폴리머 Vol.47 No.3
The physical, chemical and mechanical properties of polymer materials used in water environment for a long time will change due to their water absorption characteristics, which will affect their tribological properties. This work studied the changes of physicochemical, mechanical, and tribological properties for five kinds of polymer materials (polyethylene, polyformaldehyde,polyamide, polytetrafluoroethylene, and poly-ether-etherketone) before and after water absorption. The mechanism of water absorption for polymer materials was revealed by molecular dynamics simulation. The results show that the higher the water absorption of polymer, the larger the swelling volume, the more the surface hardness and compressive strength decrease, and the toughness and friction coefficient of the material increase obviously. The water absorption status of polymer materials is closely related to the polarity of molecular chain. Water molecules are easy to form hydrogen bonds with polymer molecular chains of high polarity, which is the main factor of water absorption.
Tribological Properties of PAO40@SiO2/UHMWPE Composites Subjected to Heavy-loading Conditions
Yao Chenyu,Jia Dan,Wan Changxin,Li Jian,Zhan Shengpeng,Yang Tian,Qi Xiaowen,Liu Changxin,Duan Haitao 한국고분자학회 2022 폴리머 Vol.46 No.5
In the present study, the ballistic impact resistance of kevlar reinforced polymer composites and shape memoryalloy sheet reinforced kevlar epoxy polymer composites have been compared numerically and experimentally. The testspecimens have been fabricated by the hand layup method, and the ballistic impact test has been conducted accordingto NIJ Level IIIA. In the current research, a new method has been proposed to measure the ballistic impact resistanceof the material by using Image J software. From the test results, it has been observed that reinforcement of shape memoryalloy in kevlar epoxy polymer composites has increased the ballistic impact resistance by 89-145% for the damaged areacompared with plain kevlar reinforced epoxy polymer composite. Also, the damaged area observed in the numerical andthe experimental results is almost the same.
Ma, Biao,Zhan, Ying,Wu, Dan,Jia, Jianping,Xu, Wentao,Luo, Yunbo 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9
To purify and characterize the fibrinogenase with high proteolytic activity from Agkistrodon halys (Chinese) Venom. Monoclonal antibodies against fibrinogenase were prepared and a novel affinity chromatography equipped with a monoclonal antibody against fibrinogenase was developed and applied for the purification of fibrinogenases. The purified fibrinogenase was identified by fibrinolytic activity assay, and antithrombosis activity assay. HPLC chromatography and SDS-PAGE analysis demonstrated the uniformity and purity of the purified fibrinogenase. In comparison with a conventional A-50 chromatography method, affinity-purified fibrinogenase showed higher activity ($3631\;U\;mg^{-1}$ vs $501\;U\;mg^{-1}$). In addition, the physiological activity of the fibrinogenase both in vitro and ex vivo showed the purified fibrinogenase can specifically degrade $\beta$-, $\gamma$-fibrinogen and has a high anti-thrombotic activity. In conclusion, the purified fibrinogenase by affinity column were shown to be homogeneous and showed a high and specific proteolytic activity against $\beta$-chains of fibrinogen molecules and antithrombosis activity.
Da-Hong Li,Jia Guo,Wen Bin,Nan Zhao,Kai-bo Wang,Jian-yong Li,Zhan-Lin Li,Hui-Ming Hua 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.7
Two novel rare chloro-containing benzylisoquinolinealkaloids, thalfoliolosumines A (1) and B (2),along with eight known isoquinoline alkaloids (3–10) wereisolated from the whole plant of Thalictrum foliolosum. The structures of these compounds were elucidated byspectral analyses, including 1D and 2D NMR (COSY,HSQC, HMBC and NOESY) experiments. The antiproliferativeeffects of all the isolated compounds were evaluatedby MTT method against MCF-7, PC-3, and U937cells, and trypan blue method against HL-60 cells. Newcompounds 1 and 2 exhibited moderate in vitro antiproliferativeactivity against MCF-7, PC-3, and HL-60 cells,and good inhibitory effects against U937 cells with IC50values of 7.50 and 6.97 μM, respectively. Compounds 7and 10 showed the strongest in vitro antiproliferative withIC50 values of 0.93 and 1.69 lM against HL-60 cell line. The antioxidant properties were also measured, bisbenzyltetrahydroisoquinolinealkaloids 3–6 showed the strongestantioxidant activities in ABTS assay.
Enhanced Curdlan Production in Agrobacterium sp. ATCC 31749 by Addition of Low-polyphosphates
Lijun Yu,Jianrong Wu,Jia Liu,Xiaobei Zhan,Zhiyong Zheng,Chi Chung Lin 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.1
A large amount of adenosine triphosphate with high energy phosphate bonds is required for uridine triphosphate regeneration during curdlan biosynthesis by Agrobacterium sp. ATCC 31749. To supply high energy for curdlan synthesis, three low-polyphosphates (Na_4P_2O_7,Na_5P_3O_10, and (NaPO_3)_6) with higher energy phosphate bonds were employed to substitute for KH_2PO_4-K_2HPO_4in fermentation medium. Two genes encoding the polyphosphate metabolizing enzymes, polyphosphate kinase and exopolyphosphatase, were amplified and showed 95%homology to those in Agrobacterium sp. C58 by sequence analysis. The curdlan yields were enhanced by 23 and 134% when phosphate concentrations 0.024 mol/L of Na_5P_3O_10 and 0.048 mol/L of (NaPO_3)_6 respectively, were added in the medium. The maximum curdlan yield of 30 ±1.02 g/L was obtained with the addition of 0.048 mol/L of (NaPO_3)_6 with 5 g/L CaCO_3 in the medium. When CaCO_3 was removed from the culture and the three lowpolyphosphates were added, the pH and biomass yield dropped remarkably and little or no curdlan was produced. The culture containing 0.048 mol/L of (NaPO_3)_6 was mixed with KH_2PO_4-K_2HPO_4 and CaCO_3 in the medium,but showed no effect on curdlan production. However,curdlan yield was improved by 49 ~ 60% when CaCO_3was removed from the medium and KH_2PO_4-K_2HPO_4acted as a buffer. It appears that the positive effect of (NaPO_3)_6 on curdlan production required the buffering capacity of CaCO_3 and the absence of KH_2PO_4-K_2HPO_4competing as a phosphate supplier.