男性不姙症의 治療에 對한 文獻的 考察

김길섭,서운교,鄭智天 東國大學校韓醫學硏究所 1994 東國韓醫學硏究所論文集 Vol.3 No.-

Studying documents & papers on the cure of mate sterility to conclusion as follows. 1. The methodes of cure were applied Onbosinyang, Jaeumbosin, Soganheul, Joseubhwadam, Boickgihyul, Hwalhyeolhwaua, Boickbisn, etc. And the causes of disease were applied Sinyanghue, Sineumhue, Ganulgihe, Damseubneon, Gihwelyanghue, Gichehyeolul, Bisinyanghue, etc. 2. Prescription were applied Chanyukdan Ojayuenjonghwan on Sinyanghue, Yukmijihwan Jibekjihwanghwan on Sinuemhue, Sihosogansan Soyosan on Ganulgiche, Changchuldodamtang Bihebunchungeum on Damseubneon, Sibjyundaebotang Paljintang on Gihyeolyanghue, Sobokchu-kuatang Gueasengjungtang on Gichehyeolul, Sibjayukguntang Bisinssangbohwan on Bisinyanghue, etc. and Ojayunjonghwan being added in the base to cure another causes of disease as well as Sinhue. 3. The cause of disease were presonted to be Sinhue mostly ; Sinvanghue particulatly. And there were usually 25∼42years old, married lives of 3~8years, cure periods of 2∼5mon-ths, general effectiveness(approximately 76%), pregnancies(approximately 47%). 4, The methodes of cure in oriental medical prepared with the causes of disease in western one are showed in blow ; The cause of semen formation disorder is considered the methodes of cure in Onbosinyang, Jaeumbosin, Boickbin and the cause of functional ejaculation disorder in mind is considered the method of cure in Sogangegwu on the base in Bosin.

Kinetic Study on Achiral-to-Chiral Transformation of Achiral Poly(diphenylacetylene)s via Thermal Annealing in Chiral Solvent: Molecular Design Guideline for Conformational Change toward Optically Dissymmetric Structures

Seo, Kyo-Un,Jin, Young-Jae,Kim, Hyojin,Sakaguchi, Toshikazu,Kwak, Giseop American Chemical Society 2018 Macromolecules Vol.51 No.1

<P>Achiral poly(diphenylacetylene)s (PDPAs: pMe3, pEt3, piPr3, pMe2OD1, pMe2ODI, and mMe3) with different alkyl side chains at the para or meta position of the side phenyl ring were prepared to examine achiral-to-chiral transformations upon thermal annealing in a chiral solvent. All the para-substituted PDPAs showed significant circular dichroism (CD) enhancement upon annealing, whereas the meta-substituted polymer, mMe3, was inert to the same treatment. To investigate the kinetics, the asymmetric conformational change was monitored by observing the changes in the magnitude of circular polarization (g(CD)) or optical rotation. PDPAs with bulkier, round-shaped side groups (pEt3 and piPr3) had greater g(CD) values at equilibrium than pMe3 with a smaller side group. Moreover, the activation energy for the forward reaction (Ea(f)) was lower in the bulkier polymers than in pMe3 owing to enhanced miscibility with the chiral solvent. Similarly, the long alkyl chains of pMe2O1 and pMe2ODI acted as internal plasticizers to lower their Ea(f) values relative to that of pMe3, whereas their g(CD) values at equilibrium were smaller than that of pMe3. The kinetics of the achiral-to-chiral transformation is discussed in detail based on the spectroscopic changes observed during the annealing process.</P>

북강활 에틸아세테이트분획의 비만세포에서의 염증반응 억제효과

서운교 ( Un Kyo Seo ),이주일 ( Ju Il Lee ),박준홍 ( Jun Hong Park ),박용기 ( Yong Ki Park ) 대한본초학회 2008 大韓本草學會誌 Vol.23 No.4

Objectives: In this study, the pharmacological effects of the ethylacetate extract of Ostericum koreanum(North Kangwhal; NK) on allergic inflammation were investigated in activated human mast cells. Methods: North Kangwhal was extracted with 80% methanol for 24 h, and then fractionated with ethylacetate(NK-EtOAc extract). HMC-1 cells, an human mast line, were pre-incubated with different concentrations of NK-EtOAc extract for 30 min, and then stimulated with PMA(50 nM/ml) and A23187(1 μM/ml) at indicated times. The cell toxicity was determined by MTT assay. The concentrations of prostaglandin E2(PGE2) and cytokines(TNF-α, IL-8) were measured by enzyme-linked immunosorbant assay. Results: NK-EtOAc extract(10~50 ㎍/ml) significantly inhibited the productions of PGE2, TNF-α and IL-8 in PMA/A23187-stimulated HMC-1 cells without cell toxicity(0~50 ㎍/ml). NK-EtOAc extract also inhibited PMA/A23187-induced phosphorylation of ERK1/2 MAPK and the NF-κB p65 subunit translocation into the nuclear of HMC-1 cells. Conclusions: This study suggests that NK-EtOAc extract may have an anti-inflammatory property through suppressing the production of inflammatory mediators in activated mast cells and its molecular mechanism underlies the blocking of NF-κB pathway.

생강 클로로포름 분획의 활성화된 뇌신경교세포(腦神經膠細胞)에서 염증반응 억제효과

서운교 ( Un Kyo Seo ),정효원 ( Hyo Won Jung ),박용기 ( Yong Ki Park ) 대한본초학회 2008 大韓本草學會誌 Vol.23 No.3

老人 喘證에 對한 文獻的 考察

徐雲敎,鄭智天 대한한방성인병학회 1995 韓方成人病學會誌 Vol.1 No.1

Study on Geriatric asthma based on literature and thesis, etc. Knowing the cause of the oriental medicine and treatment. The results obtained are as follows; 1. The cause was divided into asthenia of the kidney, the lung, the spleen and stomach. 2. Proximate cause was divided into exogenous pathogenic factor, food, emotion, overwork and chronic case. Oriental pathology was deficiency in origin and excess in superficiality, excess in the upper and deficiency in the lower. 3. The treatment was divided into stage of attack and remission stage. There was removing heat from the lung and resolving sputum with tonifying the kidney, keeping the inspired air going downward and resolving sputum with warming the kidney and reinforcing yang, ventilating the lung and resolving sputum to relieve asthma with invigorating the spleen and warming the kidney for treatment of the stage of attack. There was tonifying the lung and energy and nourishing yin, replenishing vital essence and supporting yang to tonify the kidney, warming and tonifying of the spleen and the kidney, strengthening the spleen and replenishing qi for treatment of remission stage. 4. The prescription of Geriatric asthma was as follow; Sam Ja Yang Chin Tang (treating superficiality), Geum Guae Sin Qi Hwan(treating origin), So Ja Gang Qj Tang, Saeng Maek San Hab Bo Pae Tang, Bo Pae A Gyo Tang, Maek Mun Dong Tang, In Sam Bo Pae Hwan, Sam Ja Jung Won Eum, Hab Gae Yang Pae Hwan, Suh Yeo Nab Qj Tang. Haeng Sam San(treating both the principal and the secondary aspects of a disease) etc. 5. In prescription, conservation medicine was most predominent(44%) followed by expectorant medicine, dispersive medicine in turn.

황련(黃連)의 Helicobacter pylori에 대한 항균 효과

서운교,신정인,Seo Un-Kyo,Shin Jeong-In 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.2

Water and ethanol extracts of 67 species of medicinal plants were tested to determine antimicrobial activity against Helicobacter pylori. Among them, the extracts of Coptis japonica showed the best antibacterial activity. The extract of C. japonica showed four major spots on TLC plate and the Rf values of the spots were 0.07, 0.13, 0.21 and 0.73, respectively. Except for the spot of Rf 0.73, other three spots inhibited the cell growth of H. pylori. As shown in HPLC analysis, three antimicrobial spots contain berberine, major antimicrobial substance of C. japonica. However, the spot of Rf 0.13 had higher activity than berberine. The concentrated water extract of three prescribed medicines related with C. japonica showed good antibacterial activity against H. pylori.

구맥(瞿麥)의 항돌연변이(抗突然變異) 활성(活性)에 관한 연구(硏究)

서운교,정지천,Seo Un-Kyo,Jeong Ji-Cheon 대한한의학방제학회 2003 大韓韓醫學方劑學會誌 Vol.11 No.2

Antigenotoxicity test (SOS chromotest) and antimutagenecity test (Ames test) were carried out using water-soluble and methanolic extracts from Dianthi Herba. Antigenotoxic activity of methanolic extract against mutagens both MNNG and NQO was much more effective than that of water-soluble one. When the extract was added to the certain concentration $(100\;{\mu}l/tube)$, antigenotoxic activities against both mutagens were enhanced. Against the mutagen MNNG with Ames test, antimutagenic activity of the methanolic extract was better than that of water-soluble one. The 74.6% of inhibition ratio for revertant forming CFU/plate was shown at $300\;{\mu}l/plate$ of the methanolic extract.

소청룡탕가석고(小靑龍湯加石膏) 및 ${\ll}$석실비록${\gg}$소치법방(小治法方)이 호흡기 점액의 분비에 미치는 영향

김호,서운교,Kim, Ho,Seo, Un-Kyo 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.4

Objectives : In the present study, the author intended to investigate whether two oriental medical prescriptions named Socheongryongtang-ga-seoggo (SCTS) and Prescription D (P-D) significantly affect mucin release from cultured hamster tracheal surface epithelial (HTSE) cells. Materials and Methods : Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presence of SCTS or P-D to assess the effect of each agent on 3H-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase (LDH) release. Also, the effects of SCTS and P-D on contractility of isolated tracheal smooth muscle were investigated. Results : SCTS did not affect mucin release from cultured HTSE cells, without cytotoxicity. However, P-D significantly increased mucin release from cultured HTSE cells. with significant cytotoxicity. SCTS inhibited Ach-induced contraction of isolated tracheal smooth muscle. P-D also inhibited Ach-induced contraction of isolated tracheal smooth muscle. Conclusions : The author suggests that the effects of SCTS and P-D with their components should be further investigated and it is valuable to find, from oriental medical prescriptions, novel agents which might regulate mucin secretion from airway goblet cells.

노인(老人) 천증(喘證)에 대(對)한 임상적(臨床的) 고찰(考察)

서운교,정지천,이원철,Seo, Un-Kyo,Jeong, Ji-Cheon,Lee, Won-Chul 대한한방내과학회 1993 大韓韓方內科學會誌 Vol.14 No.1

Clinical observation was done on 372 Cheon-Jeung patients more than 65 years of age in Department of Internal Medicine, Oriental Medical Hospital in Dong Guk Univ. from December 1990 to November 1991. The results were as follows; 1. The ratio of male to female was 1.2:1. The age distribution showed the large number in the 65-69 year group, the female more than the male in 8th decade. 2. The peak age in the on set was 7th decade(44.4%). 3. The ratio of the season distribution was as follows, everytime 62.6%, fall and winter 25.5%. 4. Duration from on set, the most frequence was $5{\sim}10$ years(29.6%). 5. Chief complaints were represented cough, laryngeal stridorand, dyspnea. 6. In past illness, Pulmonary. The was most predominent(29.7%) followed by allergic disease(8.1%), bronchitis(7.2%) in turn. 7. In complication, Pul. Tbc was most predominent(21.1%) followed by ronchiectasis (12.7), cardiac disease(11.3%). 8. Predisposing factors in the Geriatric athma were represented chiefly exercising(41.8%), the others is Pung-Han-Neng(27.6%), respiratory infection(12.7%) etc. 9. The recipe which used in treatment were Gamigeumsuyukgun-jeon, Gamimahwangyunpai-tang, Gamiyunpai-tang, Sojaganggi-tang, Cheongsangboha-tang etc. 10. Duration of treatment was noted within 10 days was 39.2%, $11{\sim}30$ days was 40.6%, over 60 days was 7.3%. 11. About 77.3% patients were improved.

Annealing-Induced Circular Dichroism Enhancement in Luminescent Conjugated Polymers with an Intramolecular Stack Structure

Jin, Young-Jae,Seo, Kyo-Un,Choi, Young-Ghil,Teraguchi, Masahiro,Aoki, Toshiki,Kwak, Giseop American Chemical Society 2017 Macromolecules Vol.50 No.17

<P>Two poly(diphenylacetylene) derivatives containing identical chiral pinanyl groups on the <I>para</I>- and <I>meta</I>-positions of the side phenyl ring were prepared, and their circular dichroism (CD) and photoluminescence (PL) spectra were compared. The magnitudes of circular polarization (<I>g</I><SUB>CD</SUB>) of the <I>para</I>- and <I>meta</I>-polymers were determined to be 3.1 × 10<SUP>-3</SUP> and 1.4 × 10<SUP>-3</SUP>, respectively. The PL quantum yield (PLQY) of the <I>para</I>-polymer was much greater (27.8%) than that of the <I>meta</I>-polymer (2.61%). When the two polymers were annealed at 80 °C in toluene, their CD spectra were remarkably enhanced and reached equilibrium at <I>g</I><SUB>CD</SUB> values of 9.6 × 10<SUP>-3</SUP> and 6.0 × 10<SUP>-3</SUP>, respectively. The <I>para</I>-polymer was kinetically more favored for the CD enhancement as known from the fact that the activation energies for the reactions of <I>para</I>- and <I>meta</I>-polymers were determined to be 88 and 187 kJ mol<SUP>-1</SUP>, respectively. The PLQYs of both polymers were unaffected by annealing.</P> [FIG OMISSION]</BR>