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- 저자 : ( Tomohisa Uchida ) (검색결과 4 건)
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Seiji Nakashima,Tomohisa Uchida,Kouta Takayama,Hironori Fujisawa,Masaru Shimizu 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.9
Recently, an anomalous photovoltaic effect in a BiFeO3 (BFO) thin film has attracted much attention. In this research, Pt/BFO/Pt coplanar capacitors have been prepared using striped- and single-domain structured BFO thin films, and the influence of the polarization direction of incident violet laser light (λ = 405 nm) on the photovoltage of these capacitors has been investigated. In a specific geometry, both coplanar capacitors, the one using a striped-domain and the other using a single-domain structured BFO thin film showed anomalous photovoltages above band gap of BFO, indicating that an anomalous photovoltage should be observed under randomly-polarized light illumination such as that by a halogen lamp.
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Helicobacter pylori Infection and Gastric Mucosal Atrophy in Two Ethnic Groups in Nepal
Miftahussurur, Muhammad,Sharma, Rabi Prakash,Shrestha, Pradeep Krishna,Maharjan, Ramesh Kumar,Shiota, Seiji,Uchida, Tomohisa,Sato, Hiroki,Yamaoka, Yoshio Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17
Serum anti-Helicobacter pylori antibodies and pepsinogens (PGs) have been used as gastric cancer screening and gastric mucosal status markers. Nepal is a low risk country for gastric cancer. However, the mountainous populace in the northern region culturally linked to Tibet as well as Bhutan, a neighboring country, have a high risk of GC. We collected gastric biopsy specimens and sera from 146 dyspeptic patients living in Kathmandu, Nepal. We also examined the sera of 80 volunteers living in the mountainous regions of the Himalayas. The optimal cut-off was calculated for serum biomarkers against the histology. Kathmandu patients (43.8%) were serologically positive for H. pylori infection, which was significantly lower than that for the mountainous (61.3%, P = 0.01). The same results also found in the prevalence of PG-positivity, PG I levels and PG I/II ratios (P = 0.001, P<0.0001 and P = 0.03, respectively). Moreover, the PG I/II ratios were significantly, and inversely correlated with the OLGA score (r = -0.33, P<0.009). The low incidence of gastric cancer in Nepal can be attributed to low gastric mucosal atrophy. However, the mountainous subjects have high-risk gastric mucosal status, which could be considered a high-risk population in Nepal.
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Characterizing Helicobacter pylori cagA in Myanmar
( Thein Myint ),( Muhammad Miftahussurur ),( Ratha-korn Vilaichone ),( New Ni ),( Than Than Aye ),( Phawinee Subsomwong ),( Tomohisa Uchida ),( Varocha Mahachai ),( Yoshio Yamaoka ) 대한간학회 2018 Gut and Liver Vol.12 No.1
Background/Aims: Differences in the Helicobacter pylori infection rate are not sufficient to clarify the dissimilarity of gastric cancer incidence between Myanmar and its neigh boring countries. To better understand this trend, the H. pylori virulence gene cagA was characterized in Myanmar. Methods: Glutamate-proline-isoleucine-tyrosine-alanine (EPIYA) patterns and CagA multimerization (CM) motifs of cagA genotypes were examined by performing polymerase chain reactions and DNA sequencing. Results: Of 69 tested H. pylori strains, cagA-positive patients had significantly more severe histological scores in their antrum than cagA-negative patients. Sequence analysis revealed that 94.1% of strains had Western-type cagA containing an EPIYA motif (92.6%) or EPIYT motif (6.4%). The intestinal metaplasia scores in the antral of patients infected with the ABC and ABCC types of cagA were significantly higher than those of patients with AB-type cagA. Interestingly, in patients infected with H. pylori, 46.3% of strains with three EPIYA motifs contained two iden tical Western-typical CM motifs, and these patients showed significantly higher antrum inflammation scores than pa tients infected with two identical nontypical-CM motif strains (p=0.02). Conclusions: In Myanmarese strains, Western-type cagA was predominant. The presence of CM motifs and the proportion of multiple EPIYA-C segments might partially ex plain the intermediate gastric cancer risk found in Myanmar. (Gut Liver 2018;12:51-57)
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Khangai Ayush,Akada Junko,Saruuljavkhlan Batsaikhan,Gantuya Boldbaatar,Azzaya Dashdorj,Oyuntsetseg Khasag,Davaadorj Duger,Uchida Tomohisa,Matsumoto Takashi,Yamaoka Yoshio 거트앤리버 소화기연관학회협의회 2024 Gut and Liver Vol.18 No.1
Background/Aims: A latex agglutination turbidity (LA) assay to test for serum antibodies has been approved in Japan and Korea for mass screening of Helicobacter pylori infection. In this study, we evaluated the LA assay for diagnosing H. pylori infection and predicting gastric mucosal changes in a Mongolian population. Methods: In total, 484 individuals were classified into H. pylori-positive (n=356) and H. pylori-negative (n=128) groups, as determined by histology and H. pylori culture. Results: The best cutoff, sensitivity, and specificity values for the LA assay were 18.35 U/mL, 74.2%, and 65.6%, respectively. The LA values in the atrophic gastritis group were statistically higher than those in the other groups (healthy, chronic gastritis, intestinal metaplasia, and gastric cancer, p<0.0001). The cutoff value to distinguish the atrophic gastritis group from the other four groups was 32.0 U/mL, and its area under the curve was 0.673, which was the highest among the E-plate, pepsinogen (PG) I, PG II, and PG I/II ratio tests in our data. The odds ratios for atrophic gastritis determined by the LA assay and PG I test in multiple logistic regression were 2.5 and 1.9, respectively, which were significantly higher than for the other tests. Conclusions: The LA assay can determine the risk of atrophic gastritis, which in turn is a considerable risk factor for gastric cancer. We propose using this assay in combination with the PG I/II ratio to avoid missing gastric cancer patients who have a low LA value (less than 32.0 U/mL).
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