Co가 치환된 Zn₁-xCoxO₁-δ 묽은 자성 반도체의 전자기적 특성

Cho Sang-Bum,Wi S.C,Kang Jeong-soo,Yoon S,Suh B.J. 한국자기학회 2004 한국자기학회 학술연구발표회 논문개요집 Vol.14 No.2

HCC : PE-053 ; Predicting risk factors and clinical features of liver abscess in HCC patients with postembolization syndrome after TACE

( Sung Bum Cho ),( Yen Joo Kim ),( Won Hyung Choi ),( Chung Hwan Cheon ),( Ki Hoon Lee ),( Nam Kyu Zang ),( Jin Woong Kim ),( Young Eun Joo ),( Sung Kyu Choi ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: Liver abscess was very rare but serious complication lead to liver failure and fatal outcomes after transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). This study was evaluated to clinical features of TACE related liver abscess and predicting risk factors among HCC patients who developed postembolization syndrome after TACE. Methods: From January 2008 to December 2010, 13 patients of liver abscess which was undergone percutanous drainage developed in 2582 sessions of TACE. There was retrospectively analyzed to clinical features and predicting risk factors of liver abscess compared with control group who was selected 181 patients with fever after TACE. Results: The incidence of liver abscess was 0.5%. The etiologic types were necrosis related abscess (7 cases, 54%), biloma related abscess (4 cases, 31%), indirect abscess (2 cases, 15%). The mean interval time between percutanous drainage and TACE was 51±38 days. The positive culture rate was 69 % (9 cases) and organisms were enterococcus (4), Klebsiella pnemumoniae (2), Escherichia coli (1), Citrobacter (1) and Clostridium difficile (1). Abscess group was more higher peak AST level, peak bilirubin level, single nodular type HCC, Choledocholithiasis, air forming tumoral necrosis than control group. Independent predicting risk factors to abscess was only large air forming tumoral necrosis. The overall mortality rate of abscess was 61%. 6 patients were died caused by directly related to abscess. Conclusions: TACE related liver abscess was fatal infectious complication related to extensive air forming tumoral necrosis. The clinician should be considered to possibility of developing abscess in HCC patient with high risk factors after TACE.

Feasibility of FAIR imaging for evaluating tumor perfusion

Cho, Jee-Hyun,Cho, Gyunggoo,Song, Youngkyu,Lee, Chulhyun,Park, Bum-Woo,Lee, Chang Kyung,Kim, Namkug,Park, Sung Bin,Kang, Jong Soon,Kang, Moo Rim,Kim, Hwan Mook,Kim, Young Ro,Cho, Kyoung-Sik,Kim, Jeong Wiley Subscription Services, Inc., A Wiley Company 2010 JOURNAL OF MAGNETIC RESONANCE IMAGING Vol.32 No.3

<B>Purpose:</B><P>To evaluate the feasibility of flow-sensitive alternating inversion recovery (FAIR) for measuring blood flow in tumor models.</P><B>Materials and Methods:</B><P>In eight mice tumor models, FAIR and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was performed. The reliability for measuring blood flow on FAIR was evaluated using the coefficient of variation of blood flow on psoas muscle. Three regions of interest (ROIs) were drawn in the peripheral, intermediate, and central portions within each tumor. The location of ROI was the same on FAIR and DCE-MR images. The correlation between the blood flow on FAIR and perfusion-related parameters on DCE-MRI was evaluated using the Pearson correlation coefficient.</P><B>Results:</B><P>The coefficient of variation for measuring blood flow was 9.8%. Blood flow on FAIR showed a strong correlation with Kep (r = 0.77), percent relative enhancement (r = 0.73), and percent enhancement ratio (r = 0.81). The mean values of blood flow (mL/100 g/min) (358 vs. 207), Kep (sec<SUP>−</SUP><SUP>1</SUP>) (7.46 vs. 1.31), percent relative enhancement (179% vs. 134%), and percent enhancement ratio (42% vs. 26%) were greater in the peripheral portion than in the central portion (P < 0.01).</P><B>Conclusion:</B><P>As blood flow measurement on FAIR is reliable and closely related with that on DCE-MR, FAIR is feasible for measuring tumor blood flow. J. Magn. Reson. Imaging 2010;32:738–744. © 2010 Wiley-Liss, Inc.</P>

Efficacy of the Arbekacin and Teicoplanin Combination on Glycopeptide Intermediate Staphylococcus aureus in a Rabbit Model of Endocarditis

Cho, Cheong Ho,Choi, Jun Yong,Han, Sang Hoon,Lee, Han Sung,Choi, Suk Hoon,Chin, Bum Sik,Choi, Hee Kyoung,Jeoung, Su Jin,Kim, Myung Soo,Kim, Chang Oh,Kim, Chang Ki,Yong, Dongeun,Song, Young Goo,Lee, Ky 대한감염학회 2008 감염과 화학요법 Vol.40 No.2

목적 : 동물 모델을 이용하여 GISA에 의한 심내막염에서 teicoplain과 arbekacin 병용 요법의 치료 효과를 알아보고자 하였다. 재료 및 방법 : 토끼 심내막염 모델을 이용하여 GISA 에 의한 심내막염에서 teicoplanin과 arbekacin 병용 요법의 효과를 단독 요법의 효과와 비교하였다. GISA 균주는 Mu50 균주를 사용하였고, 기존 문헌과 동일한 방법으로 토끼를 이용하여 동맥판 심내막염 모델을 사용하였다. 항생제 치료는 균을 주사한지 20시간 이후에 시작하였다. Teicoplanin은 40 mg/kg를 1회 근육 주사한 후에 20 mg/kg의 용량을 12시간 마다 4일간 투여하였다. Arbekadn은 5 mg/kg를 12시간 마다 4일간 근육 주사하였다. 마지막 항균제 투여 20시간 이후에 토끼 대동맥판의 증식(vegetation)을 채취하였다. 항균제를 투여하지 않은 대조군, teicoplanin 단독 치료군, arbekacin 단독 치료군, teicoplanin과 arbekacin 병용치료 군간의 증식의 무게(gram) 당 log_10)CFU의 차이를 비교하였다. 결과 : Teicoulanin과 arbekacin 병용 치료군에서 teicoplanin단독 치료군, 혹은 arbekacin 단독 치료군에 비해 증식의 무게(gram)당 log_10)CFU 값이 유의하게 낮았다(P<0.05). 결론 : 동물 모델에서 GISA에 의한 심내막염에 대한 teicoplanin과 arbekacin 병용 치료의 효과가 teicoplanin이나 arbekacin 단독 치료에 비해 우월하였다. Background : There have been no reports to evaluate the usefulness of combination therapy with glycopeptide and arbekacin in endocarditis by in vivo model. Materials and Methods : We investigated the efficacy of the arbekacin and teicoplanin combination on glycopeptide intermediate Staphylococcus aureus (GISA) in rabbit model of endocardits. GISA Mu50 strain was used for the experiment. The rabbit model of aortic valve endocarditis as described previously was used. Treatment was started 20h later inoculation with teicoplanin alone (at 20 mg/kg of body weight intramuscularly every 12 hours for 4 days after loading dose of 40 mg/kg of body weight intramuscularly), arbekacin alone (5 mg/kg of body weight intramuscularly every 12h for 4 days), or teicoplanin plus arbekacin. Results : The results of therapy for experimental endocarditis due to Mu50 showed that teicoplanin and arbekacin combination was more effective than the administration of both drugs alone in reducing the log_10)CFU/g of aortic vegetation (P<0.05). Conclusion : The combination of teicoplanin and arbekacin was more effective against GISA (Mu50) than both drugs alone in vivo endocarditis model.

Optimum temperature and salinity conditions for growth of green algae <i>Chlorella ellipsoidea</i> and <i>Nannochloris oculata</i>

CHO, Sung Hwoan,JI, Sung-Choon,HUR, Sung Bum,BAE, Jeanhee,PARK, In-Seok,SONG, Young-Chae Springer Japan KK 2007 Fisheries Science Vol.73 No.5

<P>ABSTRACT: </P><P>The effects of temperature and salinity on growth of green algae <I>Chlorella ellipsoidea</I> and <I>Nannochloris oculata</I> were determined to compare the optimum culture conditions. A four-temperature (15, 20, 25, and 30°C) × three-salinity (10, 20, and 30) factorial design with triplicates was applied. Specific growth rate (SGR), maximum density, and duration to reach maximum density of <I>C. ellipsoidea</I> were significantly affected by both temperature and salinity. The highest SGR was observed in <I>C. ellipsoidea</I> at 25°C and salinity 10, but the maximum density was very low. The highest maximum density was achieved in <I>C. ellipsoidea</I> at 15°C and 10. The slope constant of the linear relationship between semilogarithmic growth of <I>C. ellipsoidea</I> and day of culture was highest at 15°C and 10. The SGR and duration to reach maximum density of <I>N. oculata</I> were significantly affected by both temperature and salinity. However, maximum density of <I>N. oculata</I> was significantly affected by temperature, but not salinity. The highest maximum density was achieved in <I>N. oculata</I> at 25°C and 30, but SGR was significantly lower than that of <I>N. oculata</I> at 25°C and 10. The slope constant of the linear relationship between semilogarithmic growth of <I>N. oculata</I> and day of culture was highest at 25°C and 30. Based on these results, the condition of 15°C and salinity 10 seemed to be optimal for maximum density of <I>C. ellipsoidea</I>, and the condition of 25°C and 10 and 30 for SGR and maximum density for <I>N. oculata</I>, respectively.</P>

Strain Transmission Characteristics of Packaged Fiber Bragg Grating Sensors for Structural Health Monitoring

Cho, Sung-In,Yoo, Seung-Jae,Kim, Eun-Ho,Lee, In,Kwon, Il-Bum,Yoon, Dong-Jin The Korean Society for Nondestructive Testing 2010 한국비파괴검사학회지 Vol.30 No.3

Fiber Bragg grating(FBG) sensor arrays can be used to monitor the mechanical behavior of the large composite structures such as wind turbine rotor blades and aircrafts. However, brittle FBG sensors, especially multiplexed FBG sensors are easily damaged when they are installed in the flexible structures. As a protection of brittle FBG sensors, epoxy packaged FBG sensors have been presented in this paper. Finite element analysis and experiments were performed to evaluate the effects of adhesives, packaging materials and the bonding layer thickness on the strain transmission. Two types of epoxy were used for packaging FBG sensors and the sensor probes were attached with various bonding layer thickness. It was observed that thin bonding layer with high elastic modulus ratio of the adhesive to packaging provided good strain transmission. However, the strain transmission was significantly decreased when elastic modulus of the adhesive was much lower than the packaged FBG sensor probe's one.

Human Fibroblast-derived Multi-peptide Factors and the Use of Energy-delivering Devices in Asian Patients

Sang Bum Suh,Keun Jae Ahn,Hye Jin Chung,Ji Youn Suh,Sung Bin Cho 대한의학레이저학회 2020 MEDICAL LASERS Vol.9 No.1

Human fibroblast-derived multi-peptide factors (MPFs) have been used during treatments with energy-delivering modalities to enhance energy-induced tissue reactions. Human fibroblast-derived MPFs, which include a range of growth factors and chemoattractive factors, activate and recruit fibroblasts and endothelial cells, as well as promote extracellular matrix deposition, all of which are crucial to wound repair. Interestingly, fibroblasts from different species or anatomical sites exhibit distinct transcriptional properties with high heterogeneity. In addition, the patterns of MPF secretion can differ under a range of experimental conditions. Therefore, the use of allogeneic fibroblasts and proper cultivation thereof are necessary to obtain MPFs that can enhance the epithelial-mesenchymal interactions during wound repair. Moreover, energy-delivering devices should be selected according to evidence demonstrating their therapeutic efficacy and safety on a pathological skin condition and the major target skin layers. This paper reviewed the histologic patterns of post-treatment tissue reactions elicited by several energy sources, including non-ablative and ablative fractional lasers, intense focused ultrasound, non-invasive and invasive radiofrequency, picosecond-domain lasers, and argon and nitrogen plasma. The possible role of the immediate application of human fibroblast-derived MPFs during wound repair was proposed.

P249 : Acupuncture-related dermatosis

( Sung Min Park ),( Hyun Ho Cho ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Acupuncture is one of the most popular treatment modality in Oriental medicine to treat various diseases and to control pain, but its adverse effect can be overlooked easily. Objectives: This study was conducted to investigate kinds of dermatologic adverse effect of acupuncture and to arouse people`s attention to indiscriminate procedure. Methods: We evaluated clinicopathologic diagnosis, treatment and prognosis in patients who have causal relationship between acupuncture and dermatosis. Results: There were 23 patients with history of acupuncture. Among them, 13 patients got bee venom acupuncture. Most patients got acupuncture for pain control. The median age was 52 years and the male to female ratio was 5: 18. They were finally diagnosed with atypical mycobacterial infection, pyoderma, abscess, foreign body granuloma, bee sting reaction and others (lipoatrophy, contact dermatitis, scar). They were treated with antibiotics only, topical or intralesional or systemic steroid only, antibiotics with systemic steroid. It takes longer time to treat in cases perfomed by unlisenced personnel. Conclusion: In this study, we were able to recongnize various dermatologic adverse effects of acupuncture and danger of acupuncture perfomed by unlisenced personnel. We wish that this report could raise people and oriental doctor`s attention to adverse effects of acupuncture.

FC 1-9 : Decreased expression of type 5 17-β-Hydroxysteroid dehydrogenase (AKR1C3) protein identified in human diabetic skin tissue

( Bum Joon Ko ),( Seung Il Choi ),( Sang Jin Oh ),( Kyung O Kim ),( Jong Suk Lee ),( Sang Hoon Lee ),( Moon Kyun Cho ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Diabetes is characterized by chronic hyperglycemia, and hyperglycemia could Increase Reactive Oxygen Species (ROS) production from the mitochondrial electron transport chain. The formation of ROS in cells induces oxidative stress and activates oxidative damage-inducing genes. There is no research on oxidative damage-related genes AKR1C3 protein levels in human diabetic skin. We explored the expression of AKR1C3 in diabetic skin compared with normal skin tissue. Objectives: To compare the expression of AKR1C3 in normal skin versus diabetic skin. Methods: AKR1C3 expression was evaluated by western blotting in 6 diabetic skin tissue samples and 6 normal skin samples. Immunohistochemical staining was carried out to analyze AKR1C3 expression in the 6 diabetic skin tissue samples. Results: The western blotting showed a significant reduction in AKR1C3 protein expression in diabetic skin tissue compared to normal tissue. Immunohistochemical examination of AKR1C3 showed that it was weakly expressed in all diabetic skin samples. Conclusion: We believe that AKR1C3 is related to diabetic skin in an altered metabolic state which elevates ROS production.

Effects of combination therapy of docetaxel with selenium on the human breast cancer cell lines MDA-MB-231 and MCF-7

Sang O Park,Young Bum Yoo,Yong Hun Kim,Kwang Je Baek,Jung-Hyun Yang,Pil Cho Choi,Jeong Hun Lee,Kyeong Ryong Lee,Kyoung Sik Park 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.88 No.2

Purpose: The anticancer property and cytoprotective role of selenium in chemotherapy have been reported. However, the combination effects of selenium on chemotherapy for advanced breast cancer have not yet been clearly defined. The purpose of this study was to investigate the combined effects of selenium on chemotherapy using docetaxel on breast cancer cell lines. Methods: Under adherent culture conditions, two breast cancer cell lines, MDA-MB-231 and MCF-7, were treated with docetaxel at 500pM and selenium at 100nM, 1μM, or 10μM. Changes in cell growth, cell cycle duration, and degree of apoptosis after 72 hours in each treated group were evaluated. Results: In the MDA-MB-231 cells, the combination therapy group (docetaxel at 500pM plus selenium at 10mM) showed a significantly decreased percentage of cell growth (15% vs. 28%; P = 0.004), a significantly increased percentage of late apoptosis (63% vs. 26%; P = 0.001), and an increased cell cycle arrest in the G2/M phase (P = 0.001) compared with the solitary docetaxel therapy group. Isobologram analysis demonstrated the synergistic effect of the combination therapy in the MDA-MB-231 cells. However, in the MCF-7 cells, no significant differences in the percentage of cell growth apoptosis, the percentage of apoptosis, and the pattern of cell cycle arrest were noted between the combination therapy groups and the solitary docetaxel therapy group. Conclusion: Our in vitro study indicated that the combination of selenium with docetaxel inhibits cell proliferation through apoptosis and cell arrest in the G2/M phase in MDA-MB-231 breast cancer cells.