Long-Term Outcomes of Cytomegalovirus Reactivation in Patients with Moderate to Severe Ulcerative Colitis: A Multicenter Study

( You Sun Kim ),( Young Ho Kim ),( Joo Sung Kim ),( Seong Yeon Jeong ),( Soo Jeong Park ),( Jae Hee Cheon ),( Byong Duk Ye ),( Sung Ae Jung ),( Young Sook Park ),( Chang Hwan Choi ),( Kyeung Ok Kim ) 대한소화기학회 2014 Gut and Liver Vol.8 No.6

Background/Aims: Cytomegalovirus (CMV) reactivations are frequently observed in patients with active ulcerative colitis (UC), and ganciclovir therapy is effective in patients with steroid-refractory UC. This study aimed to determine the longterm outcomes of CMV reactivation and the long-term therapeutic efficacy of ganciclovir treatment. Methods: This retrospective multicenter study included a cohort of 72 patients with moderate-to-severe UC who were evaluated for CMV reactivation at the time of their initial UC flare. Colectomy, disease relapse, and the recurrence rate of CMV reactivation were investigated. Results: The mean duration of follow-up for the 72 patients was 43.16±19.78 months (range, 1 to 67 months). The cumulative colectomy (log-rank, p=0.025) and disease flare-up rates (log-rank, p=0.048) were significantly higher in the CMV-positive group. Of the 11 patients who were successfully treated with ganciclovir in the initial treatment, three patients (27.3%) experienced CMV reactivation, and six patients (54.5%) experienced poor outcomes, such as the need for colectomy or a steroid-dependent state. Conclusions: The patients who had CMV-reactivated UC showed poor outcomes at the long-term follow-up, and the long-term efficacy of ganciclovir therapy was marginal. Careful assessment is necessary for patients who exhibit evidence of CMV reactivation. (Gut Liver 2014;8:643-647)

Preliminary ¹⁹ F-MRS Study of Tumor Cell Proliferation with 3′-deoxy-3′-fluorothymidine and Its Metabolite (FLT-MP)

Ko, In Ok,Jung, Ki-Hye,Kim, Mi Hyun,Kang, Kyeung Jun,Lee, Kyo Chul,Kim, Kyeong Min,Noh, Insup,Lee, Yong Jin,Lim, Sang Moo,Kim, Jung Young,Park, Ji-Ae Hindawi 2017 Contrast media and molecular imaging Vol.2017 No.-

<P>The thymidine analogue 3′-deoxy-3′-[<SUP>18</SUP>F]fluorothymidine, or [<SUP>18</SUP>F]fluorothymidine ([<SUP>18</SUP>F]FLT), is used to measure tumor cell proliferation with positron emission tomography (PET) imaging technology in nuclear medicine. FLT is phosphorylated by thymidine kinase 1 (TK1) and then trapped inside cells; it is not incorporated into DNA. Imaging with <SUP>18</SUP>F-radiolabeled FLT is a noninvasive technique to visualize cellular proliferation in tumors. However, it is difficult to distinguish between [<SUP>18</SUP>F]FLT and its metabolites by PET imaging, and quantification has not been attempted using current imaging methods. In this study, we successfully acquired<I> in vivo </I><SUP>19</SUP>F spectra of natural or nonradioactive 3′-deoxy-3′-fluorothymidine ([<SUP>19</SUP>F]FLT) and its monophosphate metabolite (FLT-MP) in a tumor xenograft mouse model using 9.4T magnetic resonance imaging (MRI). This preliminary result demonstrates that <SUP>19</SUP>F magnetic resonance spectroscopy (MRS) with FLT is suitable for the<I> in vivo</I> assessment of tumor aggressiveness and for early prediction of treatment response.</P>

Synthesis and evaluation of metal purine-type complexes for lung cancer imaging

Kyeung Jun Kang,Jung Young Kim,In Ok Ko,Ji Ae Park 대한방사성의약품학회 2019 Journal of radiopharmaceuticals and molecular prob Vol.5 No.1

Purine type compounds has been recently reported to cause the death for lung cancer cell, related tomicrotubules-targeting agents (MTAs). Therefore it can be used to develop as theranostic radiopharmceuticalsin nuclear medicine or gadolinium-based MRI imaging agents by chelate chemistry. In the study, we tried tochemically bind a DOTA chelate on the end of purine compound and obtained a specific conjugate of DOTApurinefor metal coordination. In particular, radiometal like Cu-64, for the development of MRI imaging agents,can be utilized to choice good candidates before the synthesis of gadolinium complexes. By the screening ofradioisotope technique, Gd-DOTA-purine type complex was successfully prepared and showed MRI imagingfor lung cancer cell into the mouse model.

경피요골동맥삽관후 발생된 수지괴사 1례

김흥대,송선옥,이경숙 영남대학교 의과대학 1987 Yeungnam University Journal of Medicine Vol.4 No.1

경피요골동맥삽관후 수지괴사가 발생되어 손목을 절단한 1례를 보고하며, 동맥삽관후 수지괴사가 유발될 수 있는 요인으로는 사용된 카테터의 크기, 종류, 천자횟수, 삽관거치기간 및 카테터삽관후 유지방법외에도 환자의 혈액구성성분변화, 혈액응고장애, 심박출량감소상태, 성별 등을 들수가 있으며, 본원에서 발생된 예에서는 수술후 환자가 심히 움직여 끈으로 동맥삽관된 손목을 침대에 묶어 놓음으로써 카테터에 의한 혈관손상이 심했음이 가장 큰 원인일것으로 추측되며 그 외에도 혈액성분변화 및 응고장애에 의해 심한 혈전형성이나 heparin용액의 간헐적 관류시 발생될 수 있는 혈전의 전색도 가능성이 있을 것으로 사료된다. The technique of radial artery cannulation and its complications are well documented, but serious complications are rare. This is a report of one case of amputation of wrist due to finger necrosis developed from the radial artery cannulation in patient who had craniectomy surgery. This 52-year-old 70㎏ male underwent subdural hematoma removal surgery. Right radial artery cannulation was carried out percutaneously using 22 gauge Teflon extracath needle after modified Allen's test appeared to be positive. It was intermittently flushed by heparinized solution. His arterial blood pressure was maintained 100/70 - 110/80㎜Hg and 5 units of banked whole blood and 1 unit of fresh frozen plasma were transfused during 8-hours operation. Cannula was removed on the 9th hour after operation because that was obstructed. On the 12th hour after removal of cannula, his right hand noted to be cool and cyanotic. So, warm towel and hot bag applied continuonsly on the right hand and the right stellate ganglion block was carried out everyday for 4 times. However, on the 10th day after removal of cannula, necrotic change of all fingers of the right hand became worse and skin of fingers were shrunken. Therefore, disarticulation of the right wrist carried out on the 71th day of his hospitalization.

일부 치과병원 흡연환자의 구강위생용품 이용도

장경애 ( Kyeung Ae Jang ),성미경 ( Mi Gyung Seong ),강현경 ( Hyun Kyung Kang ),최정옥 ( Jung Ok Choi ),김윤신 ( Yoon Sin Kim ) 한국치위생과학회 2008 치위생과학회지 Vol.8 No.1

Synthesis and evaluation of metal purine-type complexes for lung cancer imaging

Kang, Kyeung Jun,Ko, In Ok,Park, Ji-Ae,Kim, Jung Young 대한방사성의약품학회 2019 Journal of radiopharmaceuticals and molecular prob Vol.5 No.1

Purine type compounds has been recently reported to cause the death for lung cancer cell, related to microtubules-targeting agents (MTAs). Therefore it can be used to develop as theranostic radiopharmceuticals in nuclear medicine or gadolinium-based MRI imaging agents by chelate chemistry. In the study, we tried to chemically bind a DOTA chelate on the end of purine compound and obtained a specific conjugate of DOTA-purine for metal coordination. In particular, radiometal like Cu-64, for the development of MRI imaging agents, can be utilized to choice good candidates before the synthesis of gadolinium complexes. By the screening of radioisotope technique, Gd-DOTA-purine type complex was successfully prepared and showed MRI imaging for lung cancer cell into the mouse model.

스타벅스 커피전문점의 서비스 개선을 위한 마케팅 전략

김우실(Kim Woo Sile),오경남(Oh Kyeung Nam),이영희(Lee Young Hee),조강옥(Cho Kwang Ok) 한국외식경영학회 2002 외식경영연구 Vol.5 No.1

The primary purpose of this study was to draw a marketing strategy by the analyzing today's trends and surroundings, and the attitudes of consumer on Starbucks coffeeshop, one of the most rapidly growing specialty coffeeshops, among any other take-out coffeeshop today. For the Starbucks coffeeshop, the survey was carried out with several views such as the experience of using it, the reasons of using specialty coffeeshop, the investigation about it. The main reasons for frequent specialty coffeeshop was reported that Starbuck coffeeshop to be the appropriate place for their meets and own experience of special taste. The taste of Starbucks coffee was evaluated by the degree of satisfaction, but the students needed the better atmosphere and convenient use. The marketing strategy of price is to be closely reconsidered, because most of students and business men responded to the cutdown of the price. Therefore, it was quitely recommended that the marketing strategy of better! service and special atmosphere should be preferred to the strategy of freshness. This study finally came to build up the 4 ps of marketing strategy: product marketing (new set menu), area marketing(place for target customer), promotion and price marketing(coupon, etc), and procedure marketing (reducing the time process).

유산균 발효에 의한 율피(Castanea crenata inner shell) 열수출출물의 아토피 피부 질환에 관한 효과

최미옥 ( Mi Ok Choi ),김배진 ( Bae Jin Kim ),조성경 ( Seung Kyeung Jo ),정희경 ( Hee Kyoung Jung ),이진태 ( Jin Tae Lee ),김학윤 ( Hak Yoon Kim ),권대준 ( Dae Jun Kweon ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2013 한국식품저장유통학회지 Vol.20 No.4

본 연구에서는 밤나무 과실의 속껍질인 율피를 이용하여 알레르기성 피부질환 기능성 원료로 사용 가능성을 조사하였다. 율피 열수추출물과 율피 발효추출물의 총 폴리페놀 함량은 1 ㎍/mL에서 각각 73.85±1.78, 81.32±1.73㎍/mL였으며, 동일한 농도에서 총 플라보노이드 함량은 18.72±0.20, 14.70±0.21㎍/mL 로 나타났다. 항산화 활성으로 율피 열수 추출물과 율피 발효추출물의 전자공여능은 1㎍/mL 에서 각각 73.74±1.18, 67.17±1.87%로 나타났으며, superoxide anion radical 소거능은 동일한 농도에서 각각 91.58±2.51, 100.15±4.30%로 두 그룹 간 항산화 활성은 큰 차이를 보이지 않았다. HS68 세포를 대상으로 율피 열수추출물과 율피발효추출물에 대한 세포 독성을 조사 한 결과, 율피 발효추출물에서 율피 추출물과 비교 시 세포 생존율이 1.33배 증가하였다. 또한 LPS로 유도된 RAW264.7 eotlrtpvhdptj 0.05 ㎍/mL 율피 열수추출물과 율피 발효추출물 처리에 의한 NO생산량은 각각 36.27±4.52, 29.56±4.91μM로 율피 발효 추출물 처리군에서 항염증 활성이 유의적으로 높았다. 아토피 유발 NC/Nga 마우스 모델에서율피 열수출물 및 뮬피 발효추출물을 도포하여 육안 상 관찰한 피부 병변은 율피 열수추출물 처리군에서 대조군과 비교해 피부 형태학적으로 일부 호전되는 경향을 보였으나, 율피 발효추출물 처리군은 멜라닌 함량과 피부 홍반의 감소 등 뚜렷한 개선효과를 보였으며 정상군과 유사한 피부 형태를 나타내었다. 도한 피부에 존재하는 염증성 사이토카인인 IL~1β와 TNF~a의 발현이 율피 열수추출물과 비교 시 율피 발효추출물에서는 각각 13.68, 3.63% 억제되었다. 이는 in vitro 실험과 유사하게 염증과 관련된 유전자의 발현을 저해함으로써 율피 발효추출물이 염증억제 효과는 물론 항아토피 효능을 나타내는 것으로 여겨진다. 다라서 율피 열수추출물 뿜난 아니라 율피 발효추출물 역시 아토피 피부질환을 개선하는데 유용한 물질로 활용될 수 있는 효과적인 조성물이라 사료된다. Atopic dermatitis (AD) is a common chronic inflammatory disease associated with a cutaneous hypersensitivity reaction to an allergen. Although the incidence of AD is increasing these days, therapeutics has yet to be developed for its treatment The aim of this study was conducted in order to compare and investigate the characteristic between the Castanea crenata inner shell extract (CS) and tile Castanea crenate inner shell extract fermented by Lactobacillus bifermentans (FCS) for an anti-atopic medication The total polyphenol and flavonoid contents were similar to CS and FCS. In the DPPR and superoxide anion radical scavenging, the CS and FCS had the potential for antioxidant activities. Both of them did not exhibit cytotoxicity to HS68 cells. The evaluation of the anti-inflammatory activity in Raw264.7 cells demonstrated that the FCS has inhibited the LPS-induced production of nitric oxide as compared to the CS. The anti-atopic dermatitis test was done through the induction of DNCB in AD hairless mice. The FCS has inhibited the development of the atopic dermatitis-like skin lesion by transdrmal water loss, melanin and erythema of the skin as compared to the (S. Moreover, the pm-inflammatory cytokine IL- 1 β and TNF-a production ill hairless mice were inhibited by the FCS treatment. It indicates that the fermentation of the Castanea crenata inner shell has the potential for the treatment of atopic dermatitis.

Enhanced percutaneous delivery of recombinant human epidermal growth factor employing nano-liposome system

Jeon, Sang-Ok,Hwang, Hee-Jin,Oh, Dong-Ho,Seo, Jo-Eun,Chun, Kyeung-Hwa,Hong, Sun-Mi,Kim, Min-Ju,Kim, Won-Chul,Park, Min-Sun,Yoon, Chae-Ha,Min, Kyung-Hyun,Suh, Chang-Woo,Lee, Sangkil Informa UK, Ltd. 2012 Journal of microencapsulation Vol.29 No.3

<P>We encapsulated recombinant human epidermal growth factor (rhEGF) into nano-liposomes (NLs) system for topical delivery. The rhEGF-loaded NLs were prepared using a high pressure homogenization method. Morphology and overall particle distribution of NLs were investigated using transmission electron microscopy (TEM) and high resolution microscope (CytoViva™). Particle size, zeta (<I>ζ</I>) potential and encapsulation efficiency were measured and the percutaneous delivery of NLs was evaluated using Franz diffusion cells and immunofluorescence confocal laser scanning microscopy (CLSM). The mean particle size, zeta potential and encapsulation efficiency of the NLs were 155.57 ± 2.59 nm, −57.92 ± 4.35 mV and 9.00 ± 0.39%%, respectively. TEM and microscopic analysis showed spherical, very even-sized vesicles approximately 150 nm. The skin permeation and localization of rhEGF were enhanced by NLs. CLSM image analysis provided that the NLs enhanced the permeation and localization of rhEGF in rat skin by facilitating entry through pores of skin.</P>

지역사회 50세 이상 여성의 요실금에 대한 역학조사

양승옥 ( Seung Ok Yang ),박영경 ( Young Kyeung Park ),김정희 ( Jeong Hee Kim ) 전북대학교 의과학연구소 2003 全北醫大論文集 Vol.27 No.2

저자들은 한국 여성의 요실금의 유병률을 추정하기위해 2003년 5월부터 8월사이 전북 진안군 마령면 50세 이상의 여성 612명을 대상으로 하여 설문조사 및 무료검진을 시행하였다. 이상의 지역사회를 대상으로한 본 요실금 역학조사 결과 우리나라도 상당한 요실금환자가 있다는 것을 알수있었다. 이를 바탕으로 요실금에 대한 보건당국의 계몽, 교육, 홍보 및 치료 등의 적절한 대응조치가 필요하리라 생각된다. Purpose: The goals of this study were to estimate the prevalence and relationship between urinary incontinence quality of life in community-dwelling women over 50 years old. Materials and Methods: The study was conducted in a typical farming village of Ma-lung in the southern region of Korea. The community population had 612 women over 50 years old Ma-lung. The interviews using questionnaires regarding general characteristics, obstetric history, disease-related factors, and urinary symptoms including incontinence were undertaken. In addition, physical examination were performed. Results: Of 612 female residents over 50 years old, 311 women were participated in our study. The response rate was 50.8%. The prevalence of urinary incontinence was 60.5%(188/311) of the responders. The prevalence of urinary incontinence for each decade was 60.0%, 70.2%, 56.3% and 45.3% over 50 and up to 89 years of age, respectively. The prevalence of urinary incontinence was 68.1%(111/163) in low or normal weight female (body mass index <25), and 84.8%(28/33) in overweight or obese group (body mass index >_25). The prevalence of stress incontinence was higher in overweight or obese(68.1%) than low or normal weight group(84.8%)(p<0.05). Though number of delivery did not affect the prevalence of urinary incontinence, a good correlation was found between stress urinary incontinence and number of delivery. Conclusions: The prevalence of female urinary incontinence in this study was relatively higher compared to other studies. Most of incontinent women did not recognize the incontinence as a pathological state and consequently, did not visit doctor. Such behavior suggests that they need more information and education toward urinary incontinence. Also, health care providers should pay more close attention for patient who are suffering from urinary incontinence.