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( Ju Hyun Lee ),( Junhyeon Cho ),( Sanghyuk Im ),( Beom Hee Kim ),( Chung Seop Lee ),( Jung Wha Chung ),( Yung Jung Kim ),( Eun Sun Jang ),( Jin-wook Kim ),( Hong Bin Kim ),( Sook-hyang Jeong ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Health care workers (HCW) are at high risk of sharp injury including needle stick injuries, percutaneous and mucocutaneous injuries. Hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) are causes of sharp injury-related infection. The aims of this study were to elucidate the incidence density and epidemiological characteristics of sharp injury among HCW, and to investigate the transmission rate of HBV, HCV and HIV in a Korean university hospital. Methods: This retrospective cohort study analyzed the data from the HCW self-reporting system for sharp injury, which is integrated in electronic healthcare recording system and managed by Occupational Safety and Health Office from January 2011 to December 2015. The incidence density per 100 persons (full-time equivalent employees)-year of sharp injury was calculated. Descriptive analysis was performed on the characteristics of sharp injury and transmission rate of HBV, HCV, and HIV. Results: A total of 1,076 occupational blood exposures were reported during 5 year. The total HCW number was 10,452, and the average yearly bed number was 1,072. Overall incidence density of sharp injury was 5.6 cases per 100 person-year, and 20.3 per 100 bed-year. Among the occupation type, housekeeping people in janitorial service company working in hospital wards showed the highest rate of sharp injury (14.8%) followed by doctors (8.5%) and nurses (6.2%). The most common place of sharp injury was wards, emergency room, and operating room (38.1%, 13.3% and 12.2%, respectively). The percutaneous injury accounted for 86.7% and mucocutaneous injury for 13.2%. During the 5 years, incidence rate tends to gradually decrease, and bed number per HCW was significantly associated with incidence density of sharp injury during the study period. Among the source patients, HBV, HCV, and HIV was positive in 133/681 (19%), 126/680 (18.5%) and 25/657 patients (3.8%), respectively. However, only one HCW was infected by HCV, showing HCV transmission rate of 0.8%. Neither HBV nor HIV infection occurred. Conclusions: The current incidence rate of sharp injury in a Korean university hospital HCW by highly encouraged easy reporting system was 5.6 cases per 100 person-year, and 20.3 per 100 bed-year, showing the highest incidence in housekeeping people in janitorial service company working in hospital wards. The transmission rate of HCV was less than 1%, while there was no transmitted case of HBV or HIV. Preventive measures to reduce sharp injury for HCW should be continued.
( Joo Yeong Baeg ),( In Hee Kim ),( Seung Young Seo ),( Young Seok Kim ),( Eun Uk Jung ),( Junhyeon Cho ),( Jung Wha Chung ),( Eun Sun Jang ),( Jin Wook Kim ),( Sook-hyang Jeong ) 대한간학회 2017 Gut and Liver Vol.11 No.3
Background/Aims: The association between depression and chronic hepatitis C virus (HCV) infection or pegylated interferon α and ribavirin therapy (PR therapy) has not been extensively studied in Korea. We aimed to clarify the prevalence of depression and its incidence during PR therapy in chronic hepatitis C (CHC) patients. Methods: In this prospective, multicenter study, 114 CHC patients were screened for depression using two self-reported scales, the Beck Depression Inventory-I (BDI-I) and the Hospital Anxiety and Depression scale (HADS). The incidence of depression during PR therapy was evaluated in 62 patients who underwent PR therapy during the study period. Results: The prevalence of baseline depression was 17.5% according to the BDI-I score ≥10 criterion and 4.4% according to the HADS-D score ≥8 criterion in the 114 CHC patients, and it was significantly associated with an unmarried state. During PR therapy, depression developed in 34.6% according to the BDI-I scale and 29.5% according to the HADS-D, which negatively affected sustained virologic response (SVR). Conclusions: The prevalence of depression in Korean CHC patients appears to be low compared to that in Western patients; however, its incidence during PR therapy (approximately 30%) was similar to that of other populations, which led to a lower SVR rate. Active screening and multidisciplinary management of depression during PR therapy is warranted. (Gut Liver 2017;11:426-433)