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( Sanghyuk Im ),( Ju Hyun Lee ),( Chung Seop Lee ),( Beom Hee Kim ),( Jung Wha Chung ),( Eun Sun Jang ),( Jin-wook Kim ),( Sook-hyang Jeong ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: The regular surveillance for early diagnosis of hepatocellular carcinoma (HCC) is widely recommended for high risk patient, however, its performance is suboptimal in real-life setting. This study aimed to elucidate the rate of performing surveillance and its impacts on early diagnosis and survival in newly diagnosed HCC patients in South Korea. Methods: In this prospective cohort study, newly diagnosed 350 HCC patients were consecutively enrolled from Mar 2012 to Apr 2016. A structured questionnaire survey on the HCC surveillance status was conducted by attending physicians from each patient with informed consents. Adequate surveillance was defined as serum AFP and liver imaging tests with 6-12 months interval over >2 years. Results: The adequate surveillance was performed in 92 patients (26.3%, Group 1: semiannual 83.7%, annual 16.3%), while not in 258 patients (73.7%, Group 2). Age and male proportion were not different from the two groups, however, advanced cirrhosis (Child-Pugh class B/C) was more frequent in Group 2 (18.6%) than in Group 1 (8.7%, p=0.026). Group 1 showed higher proportion of early HCC (BCLC stage 0/A, 75%) than Group 2 (50.4%, p-value <0.001). Group 1 showed longer overall survival (43.4 Mo., 95% CI 40.8-45.9) compared to Group 2 (39.1 Mo., 95% CI 36.7-41.5, p=0.017). The multivariable Cox regression analysis showed that, advanced cirrhosis (HR 1.161, 95% CI 1.79-6.38), and early stage (HR 1.431, 95% CI 3.98-20.67) were independent predictors of overall survival, while regular surveillance was insignificant (HR 1.736, 95% CI 0.82-4.64). Conclusions: Adequate surveillance was performed in less than one third of newly diagnosed Korean HCC patients, in them, 75% of HCC detected at early stage, which may improve survival of those patients. Comprehensive efforts to optimize the surveillance program for the target population should be urgently established.
Sanghyuk Im,Kan-woo Youn,Donghee Shin,Myeoung-jun Lee,Sang-Jun Choi 대한직업환경의학회 2015 대한직업환경의학회지 Vol.27 No.-
Carcinogenicity of asbestos has been well established for decades and it has similar approval standards in most advanced countries based on a number of studies and international meetings. However, Korea has been lagging behind such international standards. In this study, we proposed the approval standards of an occupational cancer due to asbestos through intensive review on the Helsinki Criteria, post-Helsinki studies, job exposure matrix (JEM) based on the analysis of domestic reports and recognized occupational lung cancer cases in Korea. The main contents of proposed approval standards are as follows; ① In recognizing an asbestos-induced lung cancer, diagnosis of asbestosis should be based on CT. In addition, initial findings of asbestosis on CT should be considered. ② High Exposure industries and occupations to asbestos should be also taken into account in Korea ③ An expert’s determination is warranted in case of a worker who has been concurrently exposed to other carcinogens, even if the asbestos exposure duration is less than 10 years. ④ Determination of a larynx cancer due to asbestos exposure has the same approval standards with an asbestos-induced lung cancer. However, for an ovarian cancer, an expert’s judgment is necessary even if asbestosis, pleural plaque or pleural thickening and high concentration asbestos exposure are confirmed. ⑤ Cigarette smoking status or the extent should not affect determination of an occupational cancer caused by asbestos as smoking and asbestos have a synergistic effect in causing a lung cancer and they are involved in carcinogenesis in a complicated manner.
다차원 색인구조 M - 트리에서 노드 색인공간의 중첩을 최소화하기 위한 효율적인 분할 알고리즘
임상혁(Sanghyuk Im),김유성(Yoosung Kim) 한국정보과학회 2003 한국정보과학회 학술발표논문집 Vol.30 No.2Ⅱ
다차원 색인 기법 M-트리는 노드의 중심점과 객체간의 상대적 거리로 색인을 구성하고, 검색 공간에 포함되는 객체를 액세스하는 기법으로서 노드들은 페이지 단위로 구성되며 하위 엔트리들을 포함할 수 있는 반경, 즉 유사도 거리에 의해 노드의 영역이 표현되어진다. 그러나 이와 같은 노드의 영역 표현에 있어서 노드 색인공간의 중첩으로 인해 질의 시 검색 패스가 증가하고 이로 인해 거리계산과 디스크 입출력의 증가를 야기하는 문제를 갖는다. 본 논문에서는 M-트리에서 문제가 되고 있는 노드 색인 공간의 중첩을 최소화할 수 있는 노드 분할 정책을 제안한다. 기존의 M-트리와는 다르게 노드의 가상 중심점을 계산하여 그것을 라우팅 객체로 만들어 노드를 커버하는 영역을 최소화하고 노드 안의 엔트리를 재분배하여 밀도 높은 노드를 구성 하도록 한다. 제안된 분할 알고리즘의 효율성을 증명하기 위한 실험 결과 색인공간의 중첩이 줄고 이로 인해 거리계산과 디스크 입출력의 횟수가 줄어듦을 보였다.
Postoperative chemoradiotherapy in high risk locally advanced gastric cancer
Sanghyuk Song,Eui Kyu Chie,Kyubo Kim,Hyuk-Joon Lee,Han-Kwang Yang,Sae-Won Han,Do-Youn Oh,Seock-Ah Im,Yung-Jue Bang,Sung W. Ha 대한방사선종양학회 2012 Radiation Oncology Journal Vol.30 No.3
Purpose: To evaluate treatment outcome of patients with high risk locally advanced gastric cancer after postoperative chemoradiotherapy. Materials and Methods: Between May 2003 and May 2012, thirteen patients who underwent postoperative chemoradiotherapy for gastric cancer with resection margin involvement or adjacent structure invasion were retrospectively analyzed. Concurrent chemotherapy was administered in 10 patients. Median dose of radiation was 50.4 Gy (range, 45 to 55.8 Gy). Results: The median follow-up duration for surviving patients was 48 months (range, 5 to 108 months). The 5-year overall survival rate was 42% and the 5-year disease-free survival rate was 28%. Major pattern of failure was peritoneal seeding with 46%. Loco-regional recurrence was reported in only one patient. Grade 2 or higher gastrointestinal toxicity occurred in 54% of the patients. However, there was only one patient with higher than grade 3 toxicity. Conclusion: Despite reported suggested role of adjuvant radiotherapy with combination chemotherapy in gastric cancer, only very small portion of the patients underwent the treatment. Results from this study show that postoperative chemoradiotherapy provided excellent locoregional control with acceptable and manageable treatment related toxicity in patients with high risk locally advanced gastric cancer. Thus, postoperative chemoradiotherapy may improve treatment result in terms of locoregional control in these high risk patients. However, as these findings are based on small series, validation with larger cohort is suggested.
Im, Sungjin,Park, Young Ran,Park, Sanghyuk,Kim, Hyeong Jin,Doh, Ji Hoon,Kwon, Kyungjung,Hong, Won G.,Kim, Byungnam,Yang, Woo Seok,Kim, TaeYoung,Hong, Young Joon Elsevier BV * North-Holland 2017 Applied Surface Science Vol.412 No.-
<P><B>Abstract</B></P> <P>This study demonstrates a method for improving supercapacitive performance of two-dimensional nanosheet-based composite electrode. As a hybridized electrostatic double layer capacitor–electrochemical pseudocapacitor (EDLC–PC) electrode, we synthesized reduced graphene oxide–polyaniline nanofibers (rGO–PANi NFs) composite electrode. For the enhanced supercapacitive performances, insulator silver chloride nanoparticles (AgCl NPs) were intercalated into the interlayer gap of rGO. The AgCl NP intercalation (i) exfoliated rGO layers and (ii) prevented rGO-self-agglomeration that makes it difficult to utilize the high surface-to-volume ratio of ideal mono- (or few-) atomic-thick rGO layers. As a result, (iii) the specific capacitance was improved in accordance with the enlarged specific surface area of rGO. Furthermore, (iv) the well-developed rGO edges, which were opened by the AgCl intercalation, enabled formation of more bonds between PANi and rGO by selective grafting of PANi to the rGO edges. Hence, the bonds of PANi–rGO, as conducting paths, substantially reduced the total electrical resistance. Enhanced specific capacitance, ion diffusion efficiency, and reduced electrical resistance indicated the bi-functional roles of AgCl NP insertion for high performance hybridized EDLC–PC electrodes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> High energy–power supercapacitor electrode is demonstrated using EDLC–PC hybridized rGO–PANi nanocomposite. </LI> <LI> A method for perpetuated intercalation of nanoparticles into interlayer gap of rGO is developed. </LI> <LI> The intercalaction (i) exfoliates rGO layers, (ii) prevents self-agglomeration, and (iii) enlarges specific surface area of rGO for high power performance. </LI> <LI> Electric resistance is substantially reduced by forming more rGO–PANi links via grafting of PANi to well-opened rGO edges. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Development of SED Camera for Quasars in Early Universe (SQUEAN)
Kim, Sanghyuk,Jeon, Yiseul,Lee, Hye-In,Park, Woojin,Ji, Tae-Geun,Hyun, Minhee,Choi, Changsu,Im, Myungshin,Pak, Soojong Astronomical Society of the Pacific 2016 Publications of the Astronomical Society of the Pa Vol.128 No.969
<P>We describe the characteristics and performance of a camera system, Spectral energy distribution Camera for Quasars in Early Universe (SQUEAN). It was developed to measure SEDs of high-redshift quasar candidates (z greater than or similar to 5) and other targets, e.g., young stellar objects, supernovae, and gamma-ray bursts, and to trace the time variability of SEDs of objects such as active galactic nuclei (AGNs). SQUEAN consists of an on-axis focal plane camera module, an autoguiding system, and mechanical supporting structures. The science camera module is composed of a focal reducer, a customizable filter wheel, and a CCD camera on the focal plane. The filter wheel uses filter cartridges that can house filters with different shapes and sizes, enabling the filter wheel to hold 20 filters of 50 mm x 50 mm size, 10 filters of 86 mm x 86 mm size, or many other combinations. The initial filter mask was applied to calibrate the filter wheel with high accuracy, and we verified that the filter position is repeatable at much less than one pixel accuracy. We installed and tested 50 nm medium bandwidth filters of 600-1050 nm and other filters at the commissioning observation in 2015 February. We found that SQUEAN can reach limiting magnitudes of 23.3-25.3 AB mag at 5 sigma in a one-hour total integration time.</P>