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( Jin Woo Wi ),( Chung Hwan Jun ),( Sung Kyu Choi ),( Hyun Soo Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: There are limited data about risk factor of HBV reactivation in HBsAg negative and HBcAb positive (HBsAg (-)/HBcAb (+)) patients underwent HSCT. The aims of study were to evaluate the risk factors and clinical outcomes of HBV reactivation in these patients. Methods: A total of 506 patients who received HSCT from January 2008 to December 2013 were analyzed retrospectively. Results: Reactivation rate of HBV in patients underwent HSCT was 4.15% (21/506). Subgroup analysis showed reactivation rate of HBV in patients with HBsAg (-)/HBcAb (+) was 5.85% (10/171). In univariate analysis for risk factor of HBV reactivation, initial detectable HBV DNA, preemptive treatment, age (>60), recipient HBsAg (+) before SCT, recipient HBsAb (-) before SCT, recipient HBcAb (+) before SCT, and donor HBsAg (+) were associated with reactivation of HBV. In multivariate analysis, signifi cant risk factors of HBV reactivation in patients underwent HSCT were old age (>60), donor HBsAg positivity. Subgroup analysis showed risk factor for reactivation of HBV in patients with HBsAg (-)/HBcAb (+) was only age (>60). Conclusions: Reactivation rate of HBV in patients with HBsAg (-)/HBcAb (+) was 5.85%. Age (>60) was only risk factor for reactivation in HBsAg (-)/HBcAb (+) patients underwent HSCT. Preemptive antiviral treatment may be needed in older HBsAg (-)/HBcAb (+) patients undergoing HSCT.
Jin Woo Wi,Nam-Ho Kim 대한의생명과학회 2017 Biomedical Science Letters Vol.23 No.3
Malnutrition is common and the major risk factor of mortality of end stage renal disease (ESRD) patients. The aim of this study is to assess nutritional status of malnutrition patients on dialysis by various methods and compare nutritional parameters of continuous ambulatory peritoneal dialysis (CAPD) patients with hemodialysis patients. 137 patients on dialysis from April 2009 to July 2013 were enrolled. Nutritional parameters of 66 CAPD and 71 hemodialysis patients were investigated by anthropometry, biochemical study, diet analysis and questionnaires. Malnutrition patients were selected by body mass index (BMI), serum albumin and pre-albumin based on International Society of Renal Nutrition and Metabolism (ISRNM) diagnostic criteria for protein-energy wasting and compared with non-malnutrition patients. In comparison of CAPD and hemodialysis patients, most anthropometric values showed no significant difference except total body water (TBW). TBW was lower in CAPD patients (P=0.024). Although serum albumin was slightly higher in hemodialysis patients (P=0.047), pre-albumin were significantly higher in CAPD patients (P=0.000). Serum blood urea nitrogen (BUN) was higher in hemodialysis patients (P=0.000). In diet analysis, Total calorie (P=0.000) and total cholesterol (P=0.012) intakes were higher in CAPD patients. Mean subjective global assessment (SGA) grade was higher in CAPD patients (P=0.003). Several nutritional parameters of CAPD patients were better than hemodialysis patients implying more intensive therapeutic approach may be needed for hemodialysis patients. We have to understand multiple factors contributing malnutrition of ESRD patients and individualized therapeutic approach is needed.
( Jin Woo Wi ),( Nam Ho Kim ),( Jung Hwan Yoon ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Malnutrition is common and the major risk factor of mortality in patients on dialysis. So far, there are limited data of nutrition of patients on dialysis. The aim of this study is to investigate and compare nutritional parameters of CAPD patients and those of hemodialysis patients. Methods: A total of 137 patients on dialysis from April 2009 to July 2013 were enrolled. Nutritional parameters of 66 CAPD patients and those of 71 hemodialysis patients were compared by diet analysis, anthropometry, laboratory study and questionnaires. Results: Most Anthropometric values showed no signifi cant difference except TBW. TBW was lower in CAPD patients (p=0.026). Nutritional biomarkers were compared. Pre-albumin was higher in CAPD patients (p=0.000). HDL, LDL and total cholesterol were higher in CAPD patients (p<0.005). In diet analysis, Total calorie (p=0.000) and Total cholesterol (p=0.012) intakes were higher in CAPD patients. Mean SGA grade was higher in CAPD patients (p=0.003). Conclusions: Many nutritional parameters of CAPD patients were better than those of hemodialysis patients. More intensive nutritional support and diet consult may be needed in hemodialysis patients.
한국의 고령 화농성 간농양 환자들의 임상적 특성과 예후
위진우 ( Jin Woo Wi ),조은애 ( Eun Ae Cho ),전충환 ( Chung Hwan Jun ),박선영 ( Seon Young Park ),박창환 ( Chang Hwan Park ),주영은 ( Young Eun Joo ),김현수 ( Hyun Soo Kim ),최성규 ( Sung Kyu Choi ),류종선 ( Jong Sun Rew ),정숙인 ( 대한소화기학회 2015 대한소화기학회지 Vol.66 No.1
Background/Aims: Incidence of pyogenic liver abscess (PLA) has been increasing worldwide, especially in the elderly population. Therefore, the aim of this study is to elucidate the clinical features and outcomes of PLA in elderly patients. Methods: A total of 602 patients diagnosed with PLA from January 2003 to January 2013 were analyzed retrospectively. The patients were divided according to two age groups; ≥65 years (n=296) and <65 years (n=306). Results: The mean age was 73.59±5.98 (range, 65-93) years in the elderly group. Significantly higher incidence of females (52.4% vs. 29.1%, p<0.001), hepatobiliary disease (41.2% vs. 24.8%, p<0.001), hepatobiliary procedure (29.4% vs. 13.7%, p<0.001), underlying malignancy (18.2% vs. 4.6%, p<0.001), culture positivity of resistant organism (20.6% vs. 14.4%, p=0.047), occurrence of complication (19.6% vs. 12.8%, p=0.026), and higher white blood cell (13.44±6.56 vs. 12.26±5.89, p=0.021), but lower rates of right lobe abscess (67.2% vs. 80.4%, p<0.001), fever (68.6% vs. 79.3%, p=0.003), and lower CRP (16.79±9.67 vs. 18.80±9.86, p=0.012) was observed in elderly PLA patients, compared to younger patients. Regarding complications, elderly patients had higher incidence of septic shock (8.1% vs. 2.3%, p=0.001) and cardiovascular disease (2% vs. 0%, p=0.014). Conclusions: More atypical presentations and complications tend to occur in elderly PLA patients compared with younger patients. Clinicians should be aware of these age-related differences in PLA and devise management strategies accordingly. (Korean J Gastroenterol 2015;66:27-32)
Wi, Seo-Hyun,Park, Jung-Min,Wee, Sung-Hwan,Park, Jae-Woo,Kim, Jin-Man The Korean Society of Food Science and Nutrition 2013 Preventive Nutrition and Food Science Vol.18 No.4
In recent years, manufacturers of animal-based foods with health claims have encountered difficulties in the labeling of their products because of a lack of regulation on defining the functionality of animal-based foods. Therefore, this study was conducted to establish the basic requirements for the development of a definition for functional animal-based foods by investigating consumer and industry awareness. Survey data were collected from 114 industry representatives and 1,100 consumers. The questions of the survey included items on production status and future production plans, functionality labeling, promotion plans, establishment of definition, the role of the government, consumer perception, and selection of products. The results show that both industry representatives and consumers believe that legislation and the provision of scientific evidence should be improved for the development of a functional animal-based foods market. The results obtained from this study will contribute to consumer trust by supplying correct information and can be utilized in the industry as basic data for the development of functional animal-based food products.
Ileal Perforation with Norovirus Gastroenteritis in a 3-Month-Old Infant
Wi, Seol Woo,Lee, Su Jin,Kang, Eun Kyeong,Cho, Sung Min The Korean Society of Pediatric Gastroenterology 2017 Pediatric gastroenterology, hepatology & nutrition Vol.20 No.2
Noroviruses have been recognized as the leading cause of epidemic and sporadic gastroenteritis since the advent of molecular diagnostic technique. They have been documented in 5-31% of pediatric patients hospitalized with gastroenteritis. Although norovirus gastroenteritis is typically mild and self-limited, it causes severe, but sometimes fatal, conditions in the vulnerable population such as immunocompromised patients, young children, and the elderly. Bowel perforation due to norovirus infection is rare. We report a case of small bowel perforation with norovirus gastroenteritis in the infant with Down syndrome during the hospitalization with pneumonia. Severe dehydration may cause bowel ischemia and could have triggered bowel perforation in this case. Physicians should be alert to the potential surgical complications followed by severe acute diarrhea, especially in high risk groups.