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RISS 인기검색어
- 검색키워드
- 저자 : ( Dhan-ah Chae ) (검색결과 11 건)
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( Dhan-ah Chae ),( Yeo-jin Lee ),( Soo-ji Ham ),( Jin-a Oh ),( Ji-hye Kim ),( Bo-ra Lee ),( Hyun-jin Choi ),( Soon-chul Myung ),( Eun-ju Lee ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
For ureteral substitution, ileum is commonly used. Appendiceal interposition often has been performed for right ureteral defects, but not commonly for left ureteral defects because of long anatomical distance. Herein we report a case of appendiceal interposition for a long left ureteral defect, caused by surgical resection of a locally recurrent cervical cancer involving the left mid-ureter. A 49-years old woman with cervical squamous cell carcinoma stage Ib1 underwent robot assisted radical hysterectomy, salpingectomy, right ovarian transposition, and pelvic and paraaortic lymphadnectomy. After 2 years, CT scan showed both ureter obstruction with hydronephrosis, and she received right ureteroneocystostomy and left distal ureteral end-to-end anastomosis after partial resection. Recurrent squamous cell carcinoma was confirmed by postoperative pathologic examination, and palliative chemoradiation was done. At 8 months after finishing treatment, serum SCC level was elevated to 2.1ng/ml and a 1.7cm sized solitary recurrent nodule around left mid-ureter and psoas muscle was found by PET-CT and MRI. We removed the recurrent mass with involved ureter and peri-ureteral tissue, and obtained negative resection margin. Because ileum was not suitable for ureteral replacement due to radiation-induced changes, appendix was used as a substitute for the 7cm left ureteral defect. After separating appendix from the cecum, mesoappendix was elongated by several cutting of superficial layer and stretching. We passed the appendix through the established window at descending mesocolon, irrigated the lumen and spatulated both ends. Finally, we anastomosed the tip of appendix to the proximal ureter, inserted D-J stent, and anastomosed the base of the appendix to the distal ureter. There has been no evidence of disease and the double-J ureteral stent has been placed for 4 months. In conclusion, appendix could be a suitable alternative to substitute the left ureteral defect.
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( Jin-a Oh ),( Dhan-ah Chae ),( Ji-hye Kim ),( Bo-ra Lee ),( Youn-joon Jung ),( Boh-ram Kim ),( Seung Hee Seo ),( Seung Bae Rho ),( Eun-ju Lee ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: DKK3 is a tumor suppressor of ovarian cancer cell. This study is to find a binding protein of DKK3 and its function in ovarian cancer cells. Methods: The binding proteins of DKK3 was screened using yeast-two hybridization and the protein interaction in the cells was validated with co-immunoprecipitation. OVCAR-3 and SKOV-3 ovarian cancer cell lines and HEK 293T cell lines were used in all experiments. MTT assay and caspase-3 activity were used to measure cell viability. Protein expression was knocked out with siRNA. Transcriptional activities were measured with luciferase report system and the value of protein expression was evaluated with Western blot analysis. Results: β2-microglobulin (β2M) was discovered as a binding protein of DKK3. The cellular functional study showed β2M promoted ovarian cancer cell growth by increasing Bcl-2 activity and reducing the activity of p21 and p53. Further β2M promoted angiogenesis through direct interaction with vascular endothelial growth factor receptor-2 (VEGFR-2), but not VEGFR-1. β2M attenuated DKK3 induced apoptosis in ovarian cancer cells and the induction of β2M-mediated VEGFR-2/Akt/mTOR phosphorylation and angiogenesis was significantly suppressed by DKK-3. Conclusion: β2M is a binding protein of DKK3, a tumor suppressor. β2M could be key protein for survival and promotion of ovarian carcinogenesis by attenuating DKK3 function.
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( Jin-a Oh ),( Dhan-ah Chae ),( Ji-hye Kim ),( Bo-ra Lee ),( Soo-ji Ham ),( Yeo-jin Lee ),( Eun-ju Lee ),( Suncheol Myung ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
A 39-year-old woman presented with lower abdominal pain and vaginal discomfort for 2 days. She previously underwent myomectomy and several times of endometrial curettage, resulting in intrauterine synechia and did not have menstruation for 3 years. She complained of severe pain on touching anterior vagina. On the pelvic examination, an opening at anterior and left lateral vaginal wall was found. Computed tomography showed left renal agenesis, linear structure at left pelvis, and inflammatory cystic lesion at caudally posterior to the bladder, which were consistent with ectopic ureter and Gartners duct cyst. Injection of contrast medium through vaginal extra-opening and ureteroscopy showed the connection between vagina and cystic lesion, in turn into ectopic ureter. The pus was drained from cystic lesion and catheter was placed for further drainage. With antibiotic treatment, she has discharged. Three months later, left ectopic ureter and cyst at the distal end of ectopic ureter were surgically removed. Our case is a rare genitourinary anomaly with left renal agenesis and ipsilateral ectopic ureters opening into supposed mesonephric duct remnant (Gartner's duct), which in turn opened into vagina and ascending infection. Clinicians should be aware of this anomaly in any patient with an absent or dysplastic kidney to detect ectopic ureter with any cystic lesion extending caudally posterior to the urinary bladder, which is consistent with a Gartners duct cyst.
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( Bo Ra Lee ),( Dhan Ah Chae ),( Jin A Oh ),( Ji Hye Kim ),( Youn Joon Jung ),( Gwang Jun Kim ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: To prove the utility of abnormal cardiac axis on the sonographic screening of congenital heart defects at 11+0 to 13+6 weeks of pregnancy in Korean population. Methods: This study was undertaken in Chung-Ang University hospital with expertise in fetal imaging in early gestation. Fetal cardiac axis was retrospectively evaluated between 11 0/7 and 13 6/7 weeks of gestation in 159 fetuses with evident four-chamber view. Cardiac axis was measured on the four-chamber view as the angle between the line that traces the long axis of the heart and the line that bisects the thorax in an anteroposterior direction. Confirmation of congenital heart disease was only based on the postnatal imaging. A normal fetal cardiac axis was characterized by a 90% confidence interval of the cardiac axis in fetuses without congenital heart defects. Multivariable logistic regression was used to assess the efficacy of the fetal cardiac axis. Results: Among 159 registered fetuses, 29 fetuses had an abnormal cardiac axis. A normal fetal cardiac axis was defined as 27 to 67°. On multivariable analysis for congenital heart defects, abnormal fetal cardiac axis (odd ratio [OR]=2.97; 95% confidence interval [CI]=1.11-7.94; p=0.030) and increased nuchal translucency (odd ratio [OR]=4.68; 95% confidence interval [CI]=1.82-12.04; p=0.001) were associated with increased likelihood of congenital heart defects compared to normal findings. Conclusion: The fetal cardiac axis could be a helpful tool for prenatal screening of congenital heart defects in the first-trimester.
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Primary Pulmonary choriocarcinoma successfully treated solely with chemotherapy
( Ji-hye Kim ),( Bo-ra Lee ),( Dhan-ah Chae ),( Jin-a Oh ),( Eun-ju Lee ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Primary pulmonary choriocarcinoma (PPC) is a highly fatal disease. Most of the lesions are localized in the unilateral lung and treated with surgical resections. So far, few cases of PPC have been bilateral, in which the treatments were not successful. We encountered a case of PPC with miliary dissemination in bilateral lungs, which was initially misdiagnosed as a tuberculosis but treated successfully, entirely with chemotherapy. A 44-year-old woman presented with chest pain and dyspnea, and her chest radiograph (chest x-ray) and chest computed tomography (CT) scan showed miliary opacities in bilateral lungs, suggesting miliary tuberculosis and metastatic tumor. However, pathologic examination of tissues obtained by CT-guided percutaneous needle biopsy showed choriocarcinoma, and the serum human chorionic gonadotropin (B-HCG) level was 665,751mIU/ml. In addition, no evidence of tuberculosis was found, and unremarkable findings of uterus and ovaries were noted. Six cycles of chemotherapy, including etoposide, methotrexate, cyclophosphamide and vincristine, induced a complete response and inhibited recurrence in the first two years after treatment. This case showed that PPC could be miliary dissemination in the lungs and that prompt chemotherapy can lead to successful management. Keywords: Primary Pulmonary Choriocarcinoma, Bilateral miliary nodule lesion, Human chorionic gonadotropin, Chemotherapy.
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Characteristics of Persistent Ductus Arteriosus in Term Pregnancy
( Ji-hye Kim ),( Jin-a Oh ),( Dhan-ah Chae ),( Gwang-jun Kim ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: Patent Ductus Arteriosus (PDA) is the most common cardiac abnormalities in neonatal life. Development of PDA is closely related to preterm births. Although PDA in full-term birth is not so frequent, its development would be embarrassing for the parents and obstetricians as well. Aim of this study was to investigate the risk factors for development of PDA in full-term births. Methods: Medical records of full term neonates with PDA were reviewed retrospectively from January 2008 through June 2019 in tertiary hospital. Diagnosis of PDA was done by the pediatric cardiologist. 114 full-term PDA cases were divided into 3 gruops by the size of PDA. Prenatal, maternal and neonatal conditions were evaluated and compared among groups. Results: Abnormal cardiac conditions were associated in 92 cases (80.7%). 22 cases of PDA occurred in isolated fashion. The top three most common cardiac abnormalities related with PDA were ASD, TR, and PFO. Most common structural cardiac defect was ASD. There were 3 groups according to PDA size (small diameter: 1~2.4mm, moderate diameter: 2.5~3.5mm, Large diameter: above 3.5mm): Small size was closed less than 7 days, neonates who expired or transferred to operation other hospitals were more likely to have other congenital cardiac defects Extra-cardiac anomalies were found in 10 cases: imperforated anus, congenital diaphragmatic hernia, cleft palate, sacrococcygeal teratoma. Low apgar score (less than 7 at 5 min) was recorded in 8 cases. Low birth weight (less than 2500g) was found in 6 cases. Conclusion: Development of PDA in full-term neonates were associated with abnormal cardiac conditions (mostly physiologic nature).
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( Ji Hye Kim ),( Bo Ra Lee ),( Dhan Ah Chae ),( Jin A Oh ),( Yeo Jin Lee ),( Soo Ji Ham ),( Hyun Jin Choi ),( Eun Ju Lee ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: To assess the feasibility and safety of robotic single-site myomectomy (RM-SPA) without accessory port for myomas larger than 7 cm by comparing the surgical outcomes between RM-SPA and the conventional two-ports laparoscopic myomectomy (LM). Methods: This retrospective analysis found 46 patients who underwent RM-SPA for myomas larger than 7cm by single surgeon at an academic hospital from 2016 to 2019. The 46 patients in LM group were selected based on propensity score matching analysis. Propensity score was computed using age, body mass index, parity, myoma number, and myoma diameter as controlling covariates, and 1:1 sample matching was performed using nearest neighbor matching method. The surgical outcomes were compared between the two groups using statistical tests including analysis of covariance (ANCOVA), Students t-test or Mann-Whitney U test, Fishers exact test, univariate linear regression analysis, and multivariate binary logistic regression analysis. Results: No case was converted to laparotomy and had intraoperative injuries. RM-SPA was successful for large myoma up to 14 cm in longest diameter. While the hospital date, estimated blood loss, hemoglobin decrease, transfusion rate, and postoperative pain did not differ between the two groups, operative time in RM-SPA group was significantly longer than that in LM group (P < 0.001). Univariate and multivariate analysis showed that large myoma (P = 0.034), the location of lower segment (P = 0.031) and the operation method of RM-SPA (P = 0.008) were significantly associated with increase operation time. Conclusion: Despite of no accessory port, RM-SPA is safe and feasible for myomas larger than 7cm.
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A novel splicing variant of b -TrCP1, a binding protein of b-catenin, in epithelial ovarian cancer
( Yeo-jin Lee ),( Bo-ra Lee ),( Ji Hye Kim ),( Dhan-ah Chae ),( Jin-ah Oh ),( Sooji Ham ),( Hyun-jin Choi ),( Eun-ju Lee ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: Three splicing variants of b-TrCP1, b-TrCP1-variants 1, 2, and 3, have been found in human cells. We sought to identify a novel variant, b-TrCP-variant 4, whose full-sequence has never been cloned, from ovarian cancer cells and evaluate its regulatory function on b -catenin. Methods: Normal and cancerous ovarian tissues were obtained and snap frozen in liquid nitrogen. Total RNA was isolated. Approximately 0.5-1.0 g of total RNA was reverse transcribed into cDNA using, real-time PCR. To quantitatively determine the mRNA concentration of the variants, real-time PCR was performed. Co-immunoprecipitation assay and b-galactosidase assay were done. The membrane bound proteins were developed by Western blot analysis. The expression and localization of the proteins was observed under by immunofluorescence staining and confocal microscopy. Luciferase activity was assessed using a dual-luciferase reporter assay kit. Results: A novel b-TrCP1-variant 4 harbors exon II instead of exon III of variant 1, with no change in the open reading frame. The expression of b-TrCP1-variant 4 is abundantly expressed in cancerous ovarian tissues rather than variant 1 and 2. Similar to variants 1 and 2, b-TrCP1-variant 4 directly interacts with b-catenin, one of the substrates of SCF-TrCP E3 ubiquitin ligase and down-regulates the transcriptional activity and protein expression of b-catenin with a significantly weaker effect than that by variants 1 and 2. However, the co-expression of b-TrCP1-variant 4 with variant 1 in same proportion has no effect, whereas other combinations effectively downregulate the activity of b-catenin, indicating that the heterodimer of variants 1 and 4 has no function. Conclusion: B-TrCP1-variant 4 could play a critical role in SCF-TrCP E3 ligase-mediated ubiquitination by acting as a negative regulator of -TrCP1-variant 1.
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