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이용주,김영주,박다진,Danny Liew,이용주 한국보건의료기술평가학회 2017 보건의료기술평가 Vol.5 No.2
Objectives: Many studies are being conducted around the globe to assess the feasibility of multiple criteria decision analysis (MCDA) in health technology assessment (HTA). In this review, we assessed MCDA methodologies and decision criteria used in HTA. Methods: A total of 35 studies published from 2005−2015 that applied MCDA in HTA were selected and the following areas were reviewed: 1) Context of the decision making: decision making setting, level (e.g., micro, meso, macro), and the assessment target (e.g., healthcare policy, drugs, health program, medical test, medical device, treatment, or surgery), 2) MCDA methodology: type of MCDA technique, weighting method, criteria elicitation method, and the participants, 3) Decision criteria: feasibility, social/population impact, intervention related factors, patient/individual-centered values, budget impact, and quality of evidence, and 4) Transparency of the decision making process: the process was considered transparent if the study disclosed the weight of each criterion, the formula used to calculate the final score or if the weighting/calculation method was well explained to the level considered acceptable by the authors. Results: Of the studies reviewed, 63.9% used MCDA for decision making at a national level, and the type of HT being assessed was most often national/regional healthcare policy (44.1%). The most prevalent method of weighting was direct weighting using scales (40.0%). Most of the studies (80.0%) conducted group discussions for criterion selection, and among the criteria, intervention-related factors such as safety and efficacy (93.9%) were most often observed, followed by budget-impact (81.8%) and patient/individual-centered values (81.8%). Conclusion: Substantial demands for incorporation of patient-centered values into the current HTA process were observed. Additionally, MCDA may be a useful tool in incorporating such values to the HTA decision framework, but unresolved methodological issues remain. Further assessment on the application of MCDA in HTA should be conducted for Korea-specific settings.
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이용주 한국생화학회 1970 BMB Reports Vol.3 No.1
The time course changes in the activity of branched-chain amino acids: 2 oxoglutarate aminotransferase (EC 2. 6. 1. 6) has been studied in the rat liver given carbon tetrachloride. Subcellular distribution of the enzyme also determined. 1. The levels of isoleucine aminotransferase showed a marked increase up to 24 hours and followed by a very slow increase during the period of 24 to 48 hours after carbon tetrachloride treatment. Valine aminotransferase activity is always slightly lower than isoleucine aminotransferase activity, and these two aminotransferase activities showed a quite similar fluctuation during the course of 96 hours after poisoning. Leucine was catalysed slowest of the three branched-chain amino acids. 2. The activity of branched-chain ammo acid aminotransferase was mostly recoverd in the soluble fraction (50-60 per cent). Mitochondrial fraction contained the activity about 15 per cent; nuclear fraction, 25 - 30 per cent; microsomal fraction, 4 - 6 per cent of the organ s total activity. 3. The enzyme activity was increasingly recovered in the soluble fraction during the subsequent stage of the poisoning, and this is probably due to the preceding solubilization of enzyme in particulate fractions.
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쉬리 Coreoleuciscus splendidus 후각기관의 해부, 조직 및 조직화학적 특성 연구
이용주 전주교육대학교 초등교육연구원 2006 初等敎育硏究 Vol.31 No.2
한국 고유종 쉬리 Coreoleuciscus splendidus의 후각기관을 실체현미경, 생물현미경, 주사전자현미경을 통해서 관찰하였으며 각 특징 들을 다른 잉어목 어류의 후각기관 구조와 비교하여 분석하였다. 본 종의 후각기관 특징은 다음과 같은 다른 표층성 경골어류들과 유사한 특징을 나타냈다. 1) 반원형 입수공, 2) 반원형 출수공, 3) 둥근 아치형의 비경계판, 4) 타원형의 후방, 5) 후판, 6) 로제트 구조, 7) 후감각뉴런, 지지세포, 기저세포, 비감각섬모세포, 면역세포 등으로 구성되는 위중층상피층의 감각상피, 8) 층상상피세포, 면역세포, 점액세포, 미확인세포 1 type으로 구성되는 편평상피층의 비감각상피. 그러나 쉬리는 1) 28~30개 후판, 2) 후선을 기준으로 수직과 방사형으로 나열되는 후판을 보유하는 로제트 구조, 3) 점액세포의 황점액소, 4) 지지세포 표면의 많은 섬모 등과 같은 고유한 후각기관 특징을 나타냈다. 결과적으로 쉬리 후각기관의 이러한 특징은 표층성 유영 습성에 적응한 구조적 특징으로 생각되며 또한 분류학적 연구에 유용할 것으로 판단된다.
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3세아의 학급 공동체 형성 과정에서 나타나는 특성 탐색
이용주 한국영유아교원교육학회 2004 유아교육학논집 Vol.8 No.1
This study investigates the characteristics in the formation of a classroom community for three year old children ate kindergarten. in order to determine the characteristics, the participants were observed. The data consisted of field notes, participant observations, daily journal writing interviews, and kindergarten literature. The results were as follows: Firstly, the characteristics became apparent over three phases. The first phase was a period of conflict between their individuality and the group. The second phase was a period of integrating the individuals needs and the groups needs. A 3year old' child in a classroom community gradually conformed to the rules of the group in order to remain a group member. The recognition of others, the formation of relationships with others, the conformity to rules were all recognised as a part of the phase. The third phase involved harmonization with the group. Most of the children were free to play and got along well in groups. Playing with others, caring for others, and self recognition as a class member were all a part of this phase. Secondly, there eight primary characteristics were identified in the formation of a kindergarten classroom community:conflict between an individual and group needs, conflicts in the are of play materials, recognition of others, the formation of relationships with others, conformity to rules, playing with others, caring for others, and self recognition as a class member. 본 연구는 3세 유아들이 학급 공동체를 형성하는 과정에서 나타나는 특성들을 탐색하여 집단에 입문하는 유아들의 사회적 발달에 도움을 주고자 하였다. 연구를 위해 경기도 안양시에 소재한 S유치원 3세반에서 한 학기 동안 참여관찰을 하였다. 연구결과, 3세아가 학급 공동체를 형성하는 과정은 세 시기로 구분되었으며, 각 시기에 따른 학급 공동체의 특성은 다음과 같다. 첫 번째 시기인 개인과 집단간의 갈등에서는 <개인의 욕구와 집단의 요구간의 갈등>과 <놀잇감에 대한 갈등>이 나타났으며, 두 번째인 개인과 집단간의 조절 시기는 <다른 사람에 대한 인식>, <다른 사람과의 관계 형성>, 그리고 <규칙 따르기>로 나타났으며, 세 번째 시기인 개인과 집단의 조화에서는 <함께 놀이하기>, <다른 사람에 대한 배려> 그리고 <학급 구성원으로서의 인식>이 나타났다.
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이용주,이건호 대한설비공학회 2010 대한설비공학회 학술발표대회논문집 Vol.2010 No.11
This paper represents solenoid design of control valve for incline angle control in variable compressor. Some theoretical and numerical analysis was performed to analyse solenoid and compared with experimental results. Maxwell program was used for numerical analysis. Through redesigns of housing body, plunger, core, and disk in control valve, a needed force was gotten. Reduction of core groove and housing body air-gap had a big influence for improving magnetic force. But increasing of disk thickness had a little effect on magnetic force. Control valve efficiency could be improved through the magnetic force increasing.
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