局所 放射線 照射가 末梢神經에 미치는 영향에 관한 電子顯微鏡的 硏究

이종기,이종용,서인수 대한병리학회 1989 Journal of Pathology and Translational Medicine Vol.23 No.1

Effects of Phloretin, Cytochalasin B, and D-Fructose on 2-deoxy-D-Glucose Transport of the Glucose Transport System Present in Spodoptera frugiperda Clone 21-AE Cells

이종기 대한의생명과학회 2006 Biomedical Science Letters Vol.12 No.1

Functional Assessments of Spodpotera Cell-expressed Human Erythrocyte-type Glucose Transport Protein with a Site-directed Mutagenesis

이종기,Lee, Chong-Kee 대한의생명과학회 2008 Biomedical Science Letters Vol.14 No.2

The baculovirus/insect cell expression system is of great value in the study of structure-function relationships in mammalian glucose-transport proteins by site-directed mutagenesis and for the large-scale production of these proteins for mechanistic and biochemical studies. In order to exploit this, the effects of substitution at the highly conserved residue glutamine 282 of the human erythrocyte-type glucose transporter have been examined by in vitro site-directed mutagenesis. The modified human transport protein has been expressed in Spodoptera frugiperda 21 cells by using the recombinant baculovirus AcNPV-GTL. To assess the functional integrity of the expressed transporter, measurements of the transport inhibitor cytochalasin B binding were performed, involving the membranes prepared from 4 days post infection with no virus, with wild-type virus or AcNPV-GTL virus. Data obtained showed that there was little or no D-glucose-inhibitable binding in cells infected with the wild type or no virus. Only the recombinant virus infected cells exhibited specific binding, which is inhibitable by D- but not by L-glucose. However, there was a notable reduction in the affinity for the potent inhibitor cytochalasin B when binding measurements of AcNPV-GTL were compared with those of AcNPV-GT, which has no substitution. It is thus suggested that although the modified and unmodified human transporters differed slightly in their affinity for cytochalasin B, the glutamine substitution did not interfere the heterologous expression of the human transporter in the insect cells.

共同抵當權者의 抵當權 一部 抛棄 및 混同으로 인한 消滅 ― 후순위저당권자의 보호를 중심으로 ―

이종기 민사판례연구회 2011 民事判例硏究 Vol.- No.33

The junior mortgagee is granted the right to subrogate the mortgage on another property possessed by the senior joint mortgagee, by the Art. 368 of the Korean Civil Act. But such a right to subrogation does not exist as a concrete one until the 'another property' comes under the auction. The junior mortgagee is not able to exercise such right to subrogation he has expected if the mortgage on another property has been extinguished either by waiver by the senior joint mortgagee or confusion(when the mortgagee acquires the ownership of the property on which the mortgage is settled, the mortgage should be extinguished, so called 'confusion'). On Dec. 10. 2009., the Supreme Court of Korea ruled on two cases concerning whether the senior joint mortgagee can still exercise the right to preferential payment under the auction when his mortgage on another property has been extinguished. The Court denied the right to preferential payment to the extent that the junior mortgagee could have been payed from the extinguished mortgage on 'another property' in order to protect the original expectation of the junior mortgagee. The Court further ruled that if the senior mortgagee has already exercised the right then he should return the payment he received as unjust enrichment. This article is designed to examine whether the junior mortgagee's original expectation should be protected and if so, how. The Court made proper conclusion by adjusting the conflicting interests and I basically support the decision in this regard. However, this principle should be restricted to the cases in which the debtor owns both properties. If one of the property is possessed by the third person(surety, a person who has pledged his property to secure debtor's obligation), the junior mortgagee cannot exercise the right to subrogation for the right of the surety to subrogation takes precedence over. When the junior mortgage has been settled on the surety's property and the senior joint mortgagee waived the right of the mortgage on the debtor's property, as in the case of 2008DA73218, the junior mortgagee cannot exercise the right to subrogation. Instead, the liability of the surety is exempted by the Art. 485 of the Korean Civil Act and the right to preferential payment of the senior mortgagee is limited to the extent, and therefore the junior mortgagee can be payed under the auction and the junior mortgagee is protected in this way. The Court made inappropriate reasoning by finding the ground for the unjust enrichment not in the theory of exemption but in the expectation of the junior mortgagee. 민법 제368조는 후순위저당권자에게 선순위 공동저당권자의 저당권을 대위할 권리를 부여하고 있는데, 후순위저당권이 설정된 목적물에 대한 저당권이 실행되지 아니한 상태에서는 대위권이 아직 현실적으로 발생하지 아니하였기 때문에 단지 대위권을 취득할 것을 기대할 뿐이다. 그런데 후순위저당권자의 기대와 달리 선순위 공동저당권자가 다른 저당목적물에 대하여 저당권을 포기하거나, 그 저당목적물에 대하여 소유권을 취득하는 등으로 저당권이 소멸하게 되는 경우, 후순위저당권자로서는 당초 저당권을 설정받을 때 대위에 대한 기대를 하면서 파악하였던 담보가치를 회수할 수 없게 되는 문제가 발생한다. 대법원 2009. 12. 10. 선고 2009다41250 판결과 대법원 2009. 12. 10. 선고 2008다72318 판결은 후순위저당권이 설정되지 아니한 목적물에 대한 저당권이 포기나 혼동으로 소멸한 이후에 선순위 공동저당권자가 후순위저당권이 설정되어 있는 목적물에 대한 경매절차에서도 우선변제권을 행사할 수 있는지 여부에 대하여 판시하고 있다. 두 판결은 모두 이러한 경우에 저당권의 소멸은 인정하되, 후순위저당권자의 대위에 대한 기대를 보호하기 위하여 저당권이 소멸한 목적물에서 만족을 얻을 수 있었던 한도 내에서 선순위 공동저당권자의 우선변제권을 부인하고, 만약 이미 배당을 받아갔다면 이를 부당이득으로 반환하여야 한다고 하였다. 본고는 이러한 경우에 후순위저당권자의 대위에 대한 기대를 보호하여야 하는지, 보호한다면 어떠한 방식으로 보호가 이루어져야 하는지에 대하여 검토하였다. 위와 같은 판례의 논리는 선순위 공동저당권자, 후순위저당권자, 기타 제3자의 이해관계를 적절히 조정한 타당한 결론이라고 생각된다. 그러나 이러한 법리는 한편 공동저당목적물의 소유자가 같은 경우에만 한정되어야 한다. 저당목적물의 소유자가 채무자와 물상보증인으로 다른 경우에는 물상보증인의 변제자대위와의 관계상 후순위저당권자는 대위권을 주장할 수 없기 때문에 대법원 2009. 12. 10. 선고 2008다72318 판결의 사례와 같이 물상보증인 소유의 부동산에 후순위저당권이 설정되었는데 선순위 공동저당권자가 채무자 소유의 부동산에 대한 저당권을 포기한 경우에는, 후순위저당권자의 대위에 대한 기대가 보호될 수는 없지만, 민법 제485조에 의하여 물상보증인의 면책이 이루어지고, 선순위 공동저당권자의 배당수령권이 그 범위에서 제한되며, 궁극적으로 그 금액이 후순위저당권자에게 배당되는 방식으로 후순위저당권자가 보호된다. 위 판결은 물상보증인의 면책의 법리에 따라 이론을 구성하지 아니한 채 후순위저당권자의 대위에 대한 기대이익 박탈 자체를 이유로 부당이득반환을 인정하였다는 점에서 타당하지 아니하다.

연구윤리 교육 컨텐츠 준비와 학습활동관리시스템 개발과 운영

이종기,박노율 한국경영학회 2009 한국경영학회 통합학술발표논문집 Vol.2009 No.08

Effects of Fluvastatin on the Pharmacokinetics of Repaglinide: Possible Role of CYP3A4 and P-glycoprotein Inhibition by Fluvastatin

이종기,최준식,방준석 대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.3

The purpose of this study was to investigate the effects of fluvastatin on the pharmacokinetics of repaglinide in rats. The effect of fluvastatin on P-glycoprotein and CYP3A4 activity was evaluated. The pharmacokinetic parameters and blood glucose concentrations were also determined after oral and intravenous administration of repaglinide to rats in the presence and absence of fluvastatin. Fluvastatin inhibited CYP3A4 activity in a concentration-dependent manner with a 50% inhibition concentration(IC50) of 4.1 μM and P-gp activity. Compared to the oral control group, fluvastatin significantly increased the AUC and the peak plasma level of repaglinide by 45.9% and 22.7%,respectively. Fluvastatin significantly decreased the total body clearance (TBC) of repaglinide compared to the control. Fluvastatin also significantly increased the absolute bioavailability (BA) of repaglinide by 46.1% compared to the control group. Moreover, the relative BA of repaglinide was 1.14- to 1.46-fold greater than that of the control. Compared to the i.v. control, fluvastatin significantly increased the AUC0-∞ of i.v. administered repaglinide. The blood glucose concentrations showed significant differences compared to the oral controls. Fluvastatin enhanced the oral BA of repaglinide, which may be mainly attributable to the inhibition of the CYP3A4-mediated metabolism of repaglinide in the small intestine and/or liver, to the inhibition of the P-gp efflux transporter in the small intestine and/or to the reduction of TBC of repaglinide by fluvastatin. The study has raised the awareness of potential interactions during concomitant use of repaglinide with fluvastatin. Therefore, the concurrent use of repaglinide and fluvastatin may require close monitoring for potential drug interactions.

스마트 폰과 mVoIP

이종기 한국인터넷정보학회 2011 인터넷정보학회지 Vol.12 No.2

Antiviral Activity of Glycyrrhetinic Acid on MA-104 Cell Infection of the K-21 Korea Human Rotavirus Isolate

이종기,이정민 대한의생명과학회 2006 Biomedical Science Letters Vol.12 No.3

흰쥐에서 모린이 니페디핀의 약물동태에 미치는 영향

이종기,최준식,Lee, Chong-Ki,Choi, Jun-Shik 대한약학회 2007 약학회지 Vol.51 No.3

The aim of this study was to investigate the effect of morin on the pharmacokinetics of nifedipine in rats. The pharmacokinetic parameters of nifedipine were measured after the oral administration of nifedipine (5 mg/kg) in the presence or absence of morin (1.5, 7.5 and 15 mg/kg, respectively). Compared to the control groups, the presence of 7.5 mg/kg and 15 mg/kg of morin significantly (p<0.05) increased the area under the plasma concentration-time curve (AUC) of nifedipine by 48.5${\sim}$68.2%, and the peak concentration (C$_{max}$,) of nifedipine by 59.9~84.2%. The absolute bioavailability(AB%) of nifedipine was significantly (p<0.05) increased by 21.5${\sim}$24.5% compared to the control (14.5%). While there was no significant change in the time to reach the peak plasma concentration (T$_{max}$) and the terminal half-life (T$_{1/2}$) of nifedipine in the presence of morin. It might be suggested that morin altered disposition of nifedipine by inhibition of both the first-pass metabolism and p-glycoprotein (P-gp) efflux pump in the small intestine of rats. In conclusion, the presence of morin significantly enhanced the oral bioavailability of nifedipine, suggesting that concurrent use of morin or morin-containing dietary supplement with nifedipine should require close monitoring for potential drug interaction.

e-Learning 협력학습을 위한 지능형 튜터 에이전트 시스템 설계의 탐색

이종기 한국경영정보학회 2006 한국경영정보학회 학술대회논문집 Vol.2006 No.-