標準原價計算과 그 會計處理 : 표준원가계산과 그 회계처리

이재희 釜山大學校 商科大學 1967 釜山商大學報 : 부산대 Vol.13 No.1

피부조직병리검사에서 최대한 많은 정보를 얻기 위해서

이재희 로얄에이알씨 주식회사 2011 로얄동물임상의학 Vol.9 No.3

피부 질환은 치료 받는 환자의 보호자나 치료를 하는 임상 수의사 모두에게 힘든 대표적 질병이다. 물론 치료가 비교적 간단한 경우도 많으나 그렇지 않은 경우가 종종 발생한다. 이런 상황은 농피증(pyoderma) 같은 병증이 발생하거나 원발적인 피부 증상이 불명확하여 정확한 진단이 어려운 경우 대부분 발생한다. 피부 진단에 빈번하게 이용되는 검사들은 보통 싸고 검사가 쉬우며 해석하기가 편하다. 피부 소파술(scraping), 곰팡이 배양, swab이나 imprint 등의 피부 세포학 검사, 그리고 trichogram 등의 검사가 대표적이다. 임상 수의사는 검사에 맞는 적절한 시료를 준비하여 결과를 해석한다. 이와 같은 검사 결과를 바탕으로 확정적 진단에 이르거나 특정 질병을 배제할 수 있다.

정확한 검사 결과를 얻기 위하여 우리가 할 수 있는 것(Sample Collection and Handling)Ⅰ

이재희 로얄에이알씨 주식회사 2011 로얄동물임상의학 Vol.9 No.1

Age-Related Deficits in the Processing of Fundamental Frequency Differences for the Intelligibility of Competing Voices

이재희 대한청각학회 2013 Journal of Audiology & Otology Vol.17 No.1

Suspension Culture-Mediated Tetraploid Formation in Mouse Embryonic Stem Cells

이재희,공승표,임정묵,이승태 사단법인 한국동물생명공학회 2012 Reproductive & developmental biology Vol.36 No.1

Suspension culture is a useful tool for culturing embryonic stem (ES) cells in large-scale, but the stability of pluripotency and karyotype has to be maintained in vitro for clinical application. Therefore, we investigated whether the chromosomal abnormality of ES cells was induced in suspension culture or not. The ES cells were cultured in suspension as a form of aggregate with or without mouse embryonic fibroblasts (MEFs), and 0 or 1,000 U/ml leukemia inhibitory factor (LIF) was treated to suspended ES cells. After culturing ES cells in suspension, their karyotype, DNA content, and properties of pluripotency and differentiation were evaluated. As a result, the formation of tetraploid ES cell population was significantly increased in suspension culture in which ES cells were co-cultured with both MEFs and LIF. Tetraploid ES cell population was also generated when ES cells were cultured alone in suspension regardless of the existence of LIF. On the other hand, the formation of tetraploid ES cell population was not detected in LIF-free condition, in which MEFs were included. The origin of tetraploid ES cell population was turned out to be E14 ES cells and not MEFs by microsatellite analysis and the basic properties of them were still maintained despite ploidy-conversion to tetraploidy. Furthermore, we identified the ploidy shift from tetraploidy to near-triploidy as tetraploid ES cells were differentiated spontaneously. From these results, we demonstrated that suspension culture system could induce ploidy-conversion generating tetraploid ES cell population. Moreover, optimization of suspension culture system may make possible mass-production of ES cells.

Comparison of the Performance of Chamber and Bag Digesters for Solid State Anaerobic Digestion of Separated Solid Fraction of Swine Manure

이재희,이승훈,김은종,조현수,안희권 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.2

The performance of chamber and bag digesters for solid state anaerobic digestion (SS-AD) of separated solid fraction of swine manure was investigated using lab-scale digester (4,460 mL total volume and 1,800 mL of effective volume) operating at 37°C for 63 days. The performance of two different digester types was evaluated in terms of the kinetic constants of methane production obtained from the Gompertz and Gaussian equations. Methane production potential of chamber and bag digester was 202 and 218 N・mL CH4/ g VS. Time to produce 95% methane production potential (T95) and calculated effective anaerobic digestion time were 55.5 days and 41.8 days for chamber digester and 52.8 days and 43.5 days for bag digester, respectively. Our results reveal that the performance was not significantly different between chamber and bag digester.

소아 폐질환에서 폐생검의 유용성

이재희,이소연,김자형,김봉성,홍수종,Lee, Jae Hee,Lee, So Yeon,Kim, Ja Hyung,Kim, Bong Sung,Hong, Soo-Jong 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.12

목 적 : 폐생검은 호흡기 질환을 가진 환아의 진단을 위해서 는 훌륭한 검사방법으로 알려져 있다. 하지만 검사를 위해서는 대부분의 경우 전신마취와 수술이라는 방법이 필요하며 이에 따른 합병증들이 우려되고 있다. 이에 소아 호흡기 질환 환자에서 폐생검이 치료에 미친 효과와 검사에 따른 부작용을 조사하여 폐생검의 유용성을 평가하고자 한다. 방 법 : 1993년 7월부터 2001년 6월까지 9년간 서울아산병원에서 폐질환 환아를 대상으로 폐생검 전과 후의 진단 및 치료의 변화 여부와 검사의 시행에 따른 부작용에 대해 후향적으로 조사하였다. 결 과 : 대상 환자는 총 19명으로 남아 13명, 여아 6명이었다. 검사 당시의 중간연령은 3년 8개월(9개월-8년 7개월)이었고, 폐생검은 개흉술로 시행한 경우가 12명, 흉강경을 이용한 경우가 7명이었다. 폐생검 결과 간질성 폐질환이 12명(64%)이었고 결핵과 바이러스 질환이 4명(21%), 그 외 다른 질환들이 3명(15%)이었다. 특히 흉부 단층 촬영 소견에서 폐쇄성 세기관지염으로 의심된 7명 중 2명에서만 조직학적으로 일치된 결과를 확인할 수 있었다. 조직 검사 후 치료 방법이 달라진 경우는 16명(84%)이었다. 이중 스테로이드 치료를 시작한 경우가 10명, 항바이러스 제제와 항생제, 결핵 제제의 투여를 시작한 경우가 5명, 사용하던 치료를 중단한 경우가 1명이었다. 검사 시행 후 생긴 합병증은 1명으로 농흉이었다. 폐생검 시행 이후 외래에서 추적 관찰한 중간기간은 1년 6개월(10일-8년)이었다. 관찰하는 동안 질병의 경과를 살펴보면 10명(53%)에서는 호전되었으며, 악화된 경우는 5명(26%), 변화가 없는 경우가 3명(16%), 추적되지 않는 경우가 1명이었다. 이들 중에서 4명(21%)이 사망하였고, 사망원인은 급성 호흡 곤란증후군 1명, 호흡부전 2명, 그리고 패혈증 1명이었다. 결 론 : 소아 폐질환에서 폐생검은 확진을 하는데 도움을 주는 비교적 안전한 검사일 뿐만 아니라 적절한 치료 방침의 결정에 많은 기여를 한다. 따라서 소아 폐질환의 진단과 치료에 폐생검의 적극적인 활용이 필요하다. Purpose : The aim of this study is to evaluate the value of lung biopsies for the management of children with lung disease. Methods : We retrospectively reviewed 19 lung biopsies done at Asan Medical Center, Seoul between 1993 and 2001. Data gathered included demographic information, underlying conditions, diagnosis before biopsy, final diagnosis, change in therapy, morbidity and mortality. Results : Nineteen patients underwent lung biopsy. Among them, 13 patients were male and six patients were female; the median age was 3.6 years(0.8 to 8.6 years). Twelve patients underwent open lung biopsies and seven patients had thoracoscopic biopsies. The overall diagnosis rate was 95 %. The most common diagnosis was interstitial lung disease(12 patients, 64%) and infection was detected in four patients(21%). The biopsy-proven bronchiolitis obliterance was confirmed in two of seven patients suspected by CT findings. Specific treatment was changed after biopsy in 16 patients (85%). The morbidity & overall mortality rates of the patients were 5%(one patient) and 21%(four patients) respectively. Only one complication was seen : empyema. The causes of death were acute respiratory distress syndrome(one patient), respiratory failure(two patients), and septicemia(one patient). Conclusion : The lung biopsy is a safe procedure and it contributes to more accurate diagnosis and proper management of pediatric lung diseases. We recommend lung biopsies should be considered more positively in the diagnosis of pediatric lung diseases.

혁신도시 유형별 지가변동요인 분석 및 지역 활성화 방안 연구

이재희,배민철,김혜림 국제차세대융합기술학회 2023 차세대융합기술학회논문지 Vol.7 No.4

본 연구는 혁신도시 유형을 도심형, 신시가지형, 신도시형으로 구분하고 도심형은 부산대연, 신시가지형은 경남진주, 신도시형은 광주전남을 대상으로 지역 특성이 유형별 지역 활성화 방안을 제시하고자 했다. 유형별 특 성을 분석하기 위해 혁신도시 성과분석, 지가변동 특성과 관련된 인구, 경제, 토지이용, 공간구조, 정주 환경, 공공 기관, 지가로 구분하고 그에 따른 분석지표를 구성하여 각 유형별 데이터를 취합했다. 분석 데이터는 공공통계데 이터, 공간데이터를 활용하여 분산분석 및 공간회귀분석을 실시했다. 그 결과 다음과 같은 결론을 제시했다. 첫째, 도심형 혁신도시에서는 새로운 혁신 도심지(CBD) 설정 및 도시공간 최적화하는 개선이 필요하다. 둘째, 신시가지 형 혁신도시에서는 혁신도시생활권 중심의 활성화 전략이 필요하다. 셋째, 신도시형 혁신도시는 지속가능하며, 혁 신적인 도시구축을 위한 질적 향상이 필요하다. This study classified inno-city types into Urban type, New town type, and New city type, and Urban type was Busan Daeyeon, New town type was Jinju, Gyeongsangnam-do, and New city type was to suggest ways to revitalize regions by type by type. In order to analyze the characteristics of each type, population, economy, land use, spatial structure, house, public instruments, and Land price related to balanced development, innovative city performance analysis, and land price were collected. For the analysis data, variance analysis and spatial regression analysis were performed using public statistical data and spatial data. As a result, the following conclusions were presented. First, in Urban type, it is necessary to establish a new urban center (CBD) and improve urban space optimization. Second, in New town type, a revitalization strategy centered on the living area is needed. Third, New city type is sustainable and needs to be improved in quality for innovative city construction.

Are Spinal GABAergic Elements Related to the Manifestation of Neuropathic Pain in Rat?

이재희,백승근,임은정,조규종,김명안,나흥식,김희진,이민희 대한약리학회 2010 The Korean Journal of Physiology & Pharmacology Vol.14 No.2

Impairment in spinal inhibition caused by quantitative alteration of GABAergic elements following peripheral nerve injury has been postulated to mediate neuropathic pain. In the present study, we tested whether neuropathic pain could be induced or reversed by pharmacologically modulating spinal GABAergic activity, and whether quantitative alteration of spinal GABAergic elements after peripheral nerve injury was related to the impairment of GABAergic inhibition or neuropathic pain. To these aims, we first analyzed the pain behaviors following the spinal administration of GABA antagonists (1μg bicuculline/rat and 5μg phaclofen/rat), agonists (1μg muscimol/rat and 0.5μg baclofen/rat) or GABA transporter (GAT) inhibitors (20μg NNC-711/rat and 1μg SNAP-5114/rat) into naïve or neuropathic animals. Then, using Western blotting, PCR or immunohistochemistry, we compared the quantities of spinal GABA, its synthesizing enzymes (GAD65, 67) and its receptors (GABAA and GABAB) and transporters (GAT-1, and -3) between two groups of rats with different severity of neuropathic pain following partial injury of tail-innervating nerves; the allodynic and non-allodynic groups. Intrathecal administration of GABA antagonists markedly lowered tail-withdrawal threshold in naïve animals, and GABA agonists or GAT inhibitors significantly attenuated neuropathic pain in nerve-injured animals. However, any quantitative changes in spinal GABAergic elements were not observed in both the allodynic and non-allodynic groups. These results suggest that although the impairment in spinal GABAergic inhibition may play a role in mediation of neuropathic pain, it is not accomplished by the quantitative change in spinal elements for GABAergic inhibition and therefore these elements are not related to the generation of neuropathic pain following peripheral nerve injury.

Unrelated Hematopoietic Stem Cell Transplantation for Children with Acute Leukemia: Experience at a Single Institution

이재희,윤회수,송준섭,최은석,문형남,서종진,임호준 대한의학회 2009 Journal of Korean medical science Vol.24 No.5

We evaluate the outcomes in children with acute leukemia who received allogeneic hematopoietic stem cell transplantation (HCT) using unrelated donor. Fifty-six children in complete remission (CR) received HCT from unrelated donors between 2000 and 2007. Thirty-five had acute myeloid leukemia, and 21 had acute lymphoid leukemia. Stem cell sources included bone marrow in 38, peripheral blood in 4, and cord blood (CB) in 14. Four patients died before engraftment and 52 engrafted. Twenty patients developed grade II-IV acute graft-versus-host disease (GVHD) and 8 developed extensive chronic GVHD. With median follow-up of 39.1 months, event free survival and overall survival were 60.4% and 67.5%, respectively, at 5 yr. Events included relapse in 10 and treatment-related mortality (TRM) in 10. The causes of TRM included sepsis in 4, GVHD in 4 (1 acute GVHD and 3 chronic GVHD), veno-occlusive disease in 1 and fulminant hepatitis in 1. Patients transplanted with CB had event free survival of 57.1%, comparable to 63.2% for those transplanted with other than CB. In conclusion, HCT with unrelated donors is effective treatment modality for children with acute leukemia. In children with acute leukemia candidate for HCT but lack suitable sibling donor, unrelated HCT may be a possible treatment option at the adequate time of their disease.