Gllosy Ground Coat 에 의한 주철법랑에 관한 연구

이희수,강인찬 대한금속재료학회(대한금속학회) 1970 대한금속·재료학회지 Vol.8 No.2

Gllosy Ground Coat에 의한 습식 鑄鐵琺瑯製造에서 가장 문제시 하고있는 점은 Coat와 素地金屬과의 密着性, Cover Coat의 硬度 및 Coat層의 發泡現象이다. 이들을 重視하여 Castings의 組成과 두께에 따른 영향, Ground Coat 組成에 따른 영향 및 燒成條件에 따른 영향등을 구명하였다.

Target identification for biologically active small molecules using chemical biology approaches

이희수,이재욱 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.9

The identification and validation of the targets of biologically active molecules is an important step in the field of chemical biology. While recent advances in proteomic and genomic technology have accelerated this identification process, the discovery of small molecule targets remains the most challenging step. A general method for the identification of these small molecule targets has not yet been established. To overcome the difficulty in target identification, new technology derived from the fields of genomics, proteomics, and bioinformatics has been developed. To date, pull-down methods using small molecules immobilized on a solid support followed by mass spectrometry have been the most successful approach. Here, we discuss current procedures for target identification. We also review the most recent target identification approaches and present several examples that illustrate advanced target identification technology.

노인장기요양보험제도에 관한 연구 - 일본을 중심으로 -

이희수 한양법학회 2019 漢陽法學 Vol.30 No.4

This paper aims to organize from the time of the introduction of the insurance system in Japan to the present, and to organize the main tasks of the insurance system. The four items were analyzed mainly for the modification of the insurance policy and its tasks in the provision of services, including the increase of the insurance budget and the use of services, the project to support caregivers (adopters) and the reaffirmation of the role of the 4 correctional village. The conclusion of this paper is that although the fundamental part of a change in the 1 insurance system is changing every time the policy is revised, the view that support the entire life of the elderly is important not just to provide "improvement" services, and 2 that family improvement is still a large part of the family care system, and that support for family caregivers is not in place, such It is necessary to identify whether there is, and reaffirm that taking on the final public responsibility in service use is an important role for the municipal government. Finally in this paper, there are several measures to enhance social insurance by improving the operation status of insurance systems in Japan and Korea, first of all, strengthening the diversity and appropriateness of insurance benefits is required. Long-term care services for the elderly should be equipped with a program system for overall quality improvement associated with the lives of the elderly, as well as services such as nursing, bathing and nursing. Second, it is necessary to secure regional balance of insurance facility infrastructure and quality level of service. Third, job security and professionalism of nursing staff are required. Fourth, expansion of treasury support and reduction of principal burden are required. In conclusion, the long-term care insurance system for the elderly is an important social system that responds to the elderly and family problems in the coming aged society. It should always be considered that the policy goal of the system is to improve the quality of life for senior citizens and their families in need of help, to make the service easy to use, to provide quality service as well as possible, and to ensure that the necessary resources are raised evenly and efficiently managed.

평생학습관 되돌아보기

이희수 은평구평생학습관 2016 은평시민대학 자료집 Vol.2016 No.-

Expression of Interleukin-8 and monocyte chemoattractant protein-1 in the Human Dental Pulps after stimulation with Substance P

이희수 대한구강해부학회 2010 대한구강해부학회지 Vol.32 No.1

Aim : To investigate whether leukocyte infiltration during neurogenic inflammation in the pulp is regulated by neuropeptides via inducing the release of proinflammatory chemokines interleukin-8 (IL-8) from human dental pulp , Methods : Primary human dental pulp tissue explants were stimulated with substance P (SP) , IL-8 produced in pulp explants was examined by immuno- histochemistry. Results : After the pulp tissues explants were cultured for 12 h and 24 h in the medium without FBS, IL-8 were expressed only around the cell rich zone and blood vessels in the pulp tissues , SP(10-4 M) induced lL-8 expression in the pulp tissue explants after 24 h of SP stimulation, while TNF-a(20ng/ml) did not induce the IL-8 in the pulp tissue. The stronger lL-8 staining was detected in the pulp tissue explants after 6 and 12 h of TNF-a(20ng/mI) stimulation, while only dead cells were revealed in the pulp tissue after 24 h of TNF-a(20ng/mI) stimulation. Conc1usions : SP significantly induces IL-8 expression in human dental pulp suggesting an important role of SP in recruiting neutrophils in localized pulp tissue , SP may have positive relation with the inflammation of the human dental pulp tissues.

초고속활성 탐색법을 활용한 신경보호 효능 천연물 소재 탐색 연구

이희수 대한구강해부학회 2022 대한구강해부학회지 Vol.43 No.1

글루타메이트 유도 산화 스트레스는 신경 세포 사멸의 주요 원인이다. 산화 스트레스는 반응성 산소종(ROS) 매개 세포 사멸 및 MAPK 활성화의 상위 신호전달체계인 세포의 Ca2+ 농도를 증가시킨다. 따라서항산화 물질는 산화 스트레스로 인한 신경 세포 사멸에 대한 신경 보호 물질로 활용될 수 있다. 천연 제품에는 플라보노이드, 폴리페놀 등을 포함한 많은 항산화성 분자들이 포함되어 있다. 초고속활성탐색법은 짧은 시간 내에 생리활성물질을 발굴할 수 있는 가장 효과적인 접근 방식이다. 특히천연물은 그 활성을 평가하는데 필요한 많은 종류의 화학성분을 포함하고 있다. 본 연구에서는 신경세포 보호 천연물을 발굴하기 위해 초고속활성탐색법 활용했다. 본 연구에서는 한국에서 얻은 80 가지 천연물 추출물로부터 초고속활성탐색을 통해 신경세포를 보호하는 특성을 가진 3가지 천연물을 확인했다. 신경세포 보호 천연물 추출물을 확인하기 위해 생쥐의 해마에서 유래된 신경세포인 HT22 세포에 글루타메이트를 사용하여 신경세포에 독성유발하는 모델을 활용했다. 본 연구에서는 초고속 활성탐색을 통해 백화사설초, 수양버들 및 비수리가 신경세포를 보호하는 효능을지닌 천연물로 확인되었다.

인문산책 : 해상 실크로드를 찾아서 ⑧ 오만 무스카트 -최고 선박기술 "신드바드의 고장" 로마에서 신라까지 잇는 항해 요충지

이희수 포스코경영연구소 2015 CHINDIA Plus Vol.107 No.-

The effect of magnetic fields on the MC3T3-E1 cells attachment

이희수 대한구강해부학회 2012 대한구강해부학회지 Vol.33 No.1

To determine the effects of magnetic fields by comparing interaction between the osteoblast and titanium dental implant with a magnet which is inserted in the specially designed implant abutment. Dental implants connected with a magnet - inserted abutment were used. A cell-spreading assay in which percentages of cells at four different stages of attachment were identified by scanning electron microscopy and quantified within 30 min. 4hour and 24hour attachment periods. The surfaces of dental implant connected with a MagScrew showed significantly enhanced rates of cell spreading in comparison with the others. Based on these observations. it appears reasonable to suggest that magnetic fields promote the differentiation and maturation of osteoblasts by affecting the expression of adhesion proteins imbedded in the cell membrane and may have a favorable effect on immediateloading implant treatment by reducing the processing time for mineralization.

HPLC를 이용한 육류중 바이피리딜리움계 제초제 잔류분석

이희수,이혜숙,조병훈,김병용,이광직,이명헌,박은정,김문배,이성모,조준형,박종명,정갑수,김옥경 한국수의공중보건학회 2001 예방수의학회지 Vol.25 No.4

A simultaneous and rapid method for determination of bipyridylium herbicides, paraquat dichloride and diquat dibromide have been developed in meat using high-performance liquid chromatography (HPLC) at UV 255/310nm. It is possible to detect effectively below maximal residue levels (MRL) set in CODEX and Korea with little amount of sample. Based on the collaborative studies in 3 laboratories, the mean of recovery within laboratory repeatability were 108.7%, 93.5% and 105.7%, respectively and the coefficient of variation were 6.9%, 9.8% and 12.1% in paraquat analysis. In case of diquat analysis, the mean of recovery were 86.3%, 87.0% and 86.3%, respectively and the coefficient of variation were 13.2%, 8.9% and 7.6%, respectively of which results would be acceptable to recommended guideline of CODEX. In addition, the coefficient of variation between laboratory repeatability were 7.9% and 9.7% in paraquat and diquat, respectively which would be also acceptable to the guideline of CODEX. In conclusion, the present method which would be equivalent to an official method of analysis makes feasible both for qualified determination in meat and for precise diagnosis of intoxification caused by paraquat and diquat, bipyridylium herbicides.

대학체육실기 '산악등반' 수업의 교육적 효과에 관한 연구

이희수 한국사회체육학회 2018 한국사회체육학회지 Vol.0 No.71

The purpose of this study is to analyze learning experiences in the ‘mountain climbing activities’ as a college physical activity course and its educational effects in the respect of well-rounded education. The number of participants in this study was six students, one from each group out of 20 students who took part in the outdoor sport course ‘climbing Cheonwang Peak of Jiri mountain’ during 2 days in the fall semester, 2016. They were randomly selected to engage in interviews done before and after the climbing activity. Personal documents written by each participant were collected after the climbing activity. In addition, participant observation was conducted throughout the climbing activity. For data analysis, the constant comparative method for inductively analyzing data was done to categorize themes connected with the research questions, participants’motivation, course satisfaction and educational effects. First, in terms of the participation motivation, the participants indicated positive aspects such as academic stress relief and new experiences in a natural environment, friendship and challenge as well as a negative aspect such as easily achieving a credit. Second, in terms of course satisfaction, negative factors such as poor environment for shelters and a low level of physical fitness were found. Third, educational effects in well-rounded education were drawn in relation to understanding the nature, considering others, realizing the importance of cooperation, filling a body and mind, promoting friendship, taking times for introspection, developing confidence for a future life and achieving a happy life through leisurely life style. Thus, it is necessary to satisfy students’needs and interests through more developed college physical activity programs, achieving the purposes of well-rounded education.