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섬개야광나무 잎 추출물 및 분획물의 생리활성 평가 및 활성 물질 분리
유남호(Nam Ho Yoo),김희규(Hee Kyu Kim),송재모(Jae Mo Song),이찬옥(Chan Ok Lee),박주희(Ju Hee Park),박병준(Byung Jun Park),최영빈(Yeong Bin Choi),백영선(Young Sun Baek),황연지(Yeon Ji Hwang),김명조(Myong Jo Kim) 한국약용작물학회 2019 한국약용작물학회지 Vol.27 No.6
Background: Previously, studies have observed that the leaf extract of Cotoneaster wilsonii Nakai has potent antioxidant and anti-inflammatory activites. Therefore, further research was conducted to separate the active antioxidant and anti-inflammatory compounds in the leaf of the C. wilsonii. Methods and Results: The anti-oxidant effects were evaluated by analyzing the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, estimating the totla phenolic content (TPC) and total flavonoid content (TFC), and using reducing power assay method. The ethyl acetate (EtOAc) fraction demonstrated the highest DPPH radical scavenging activity (IC<SUB>50</SUB>; 9.69 ㎍/㎖), and the highest TPC and TFC (345.98 ㎎·GAE/g, and 74.23 ㎎·QE/g). Moreover, it indicated the highest effects on nitric oxide production. Therefore, the active compound was separated using the EtOAc fraction, determined on the basis of spectral data, and identified as (+)-catechin. Conclusions: The first compound separated was made from the leaf of C. wilsonii was (+)-catechin, which produced potent anti-oxidant and anti-inflammatory effects.