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약물-질병 경로 네트워크의 구축과 비교를 통한 신약재창출
황소윤(Soyoun Hwang),황유현(Youhyeon Hwang),오민(Min Oh),윤영미(Youngmi Yoon) 한국정보기술학회 2016 한국정보기술학회논문지 Vol.14 No.9
As genome data are continuously increasing, there have been various efforts that elucidate a mechanism of drug action. However, the mechanism of drug action is still not elucidated perfectly despite various previous efforts. In this paper, we constructed drug-disease gene network based on protein-protein interaction to better understand a mechanism of drug action, and applied drug repositioning. In order to construct pathway networks for drug-disease pairs, we connected the drug target genes, drug related genes and the disease related genes respectively. We extracted critical gene networks for particular drug-disease pairs of which therapeutic indications are known. By estimating similarity between the critical gene networks and candidate networks derived from drug-disease pairs whose therapeutic effects are unknown, new drug indications were predicted. The putative drug indications significantly overlapped with those of CTD database (Fishers exact P = 7.01E-104). In performance evaluation, the prediction result showed the area under the ROC curve (AUC) of 0.7122.