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        소아 편두통에 대한 Topiramate의 치료효과

        김현석(Hyon seok Kim),황성진(Sung Jin Whang),이준화(Jun Wha Lee),김태홍(Tae Hong Kim),이주석(Joo Seok Lee),조경래(Kyung Lae Cho) 대한소아신경학회 2007 대한소아신경학회지 Vol.15 No.1

        목 적 : 편두통 환자, 특히 전조가 동반된 편두통 환자에 대한 topiramate의 치료 효과를 알아보기 위해 본 연구를 시행했다. 방 법: 2004년 1월 1일에서 2006년 12월 31일까지 편두통으로 진단하여 topiramate를 투여한 27명을 대상으로, 국제두통학회의 편두통 진단 기준에 따라 증세 호전의 차이가 있는 지 분석하였다. 결 과: 편두통의 진단 조건과 topiramate 투여 후의 증세 변화에는 상관관계가 있었다. 구토 구역 증세 및 빛과 소리에 대한 과민성 여부는 topiramate 투여 후의 증세변화와 관련이 없었다. 전조의 존재는 topiramate 투여 후 증세 개선과 관련이 있었고 특히 증세가 소실된 경우와 밀접한 관련이 있었다. 결 론 : 보다 정확한 진단과 전조의 존재가 topiramate의 치료 효과를 높이는 요인인 것으로 판단된다. Purpose : This study was undertaken to investigate the therapeutic effects of topiramate on pediatric patients with migraine, especially migraine accompanied by aura. Methods : From January. 2004 to December. 2006, we reviewed the medical records of 27 patients who were diagnosed as migraine and treated with topiramate. And we analysed to see whether there was any improvement of symptoms based on the migraine criteria by International Headache Society. Results : There was a correlation between the migraine criteria and the improvement of symptoms after the treatment by topiramate. The symptoms of nausea, vomiting and hypersensitivity to light and sound were not associated with the improvement of symptoms after the treatment by topiramate. The symptom of aura was related with the improvement of symptoms, moreover, closely related with disappearance of symptoms after the treatment by topiramate. Conclusion : It is estimated that more accurate diagnosis coupled with the presence of aura is a condition to improve the treatment effects of topiramate.

      • SCOPUSKCI등재

        소아 화상 환자에 대한 임상적 연구

        정만,황성진,이현택,김정헌,김동철 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.3

        From Jan. 1988 to July 1990, 1641 burn patients were admitted to Hangang Sacred Heart Hospital. Among them, 538 patients were under the age of fifteen. In these pediatric burn patients, retrospective study was done for the review of following issuses ; age and sex destribution, causes of burn, monthly, daily and hourly distribution of accidents, prevalent area of burn and duration of admission, mortality rate and causes of deaths according to the extents of burn. The results were as follows ; 1) Children under 15years old were 32.8% of all admitted burn patients(1641). 2) Males were more frequently affected, and their percentage was 56.9%. 3) The most prevalent age group was between 1 and 2 years old(27.1%). 4) The most common cause of burns were scalds(78.4%), followed by flame(19%), contact(1.7%) and electric(1%). 5) Burning accidents were frequently occurred in March and October, on Sunday and at 7-8PM, 1-2PM and 9-10AM. 6) Lower extremity was most frequently involved(36%), followed by upper extremity(22.6%), trunk(21.7%), hand(9.7%) and head & neck(9.6%). 7) The mean hospital day was 21.4% days, and days of admission were abruptly prolonged over 40% burn of total body surface. 8) Overall mortality rate was 8.1%(40 cases), and causes of deaths were sepsis(62.5%), respiratory failure(25%), asphyxia(2.5%), hypovolemic shock(2.5%) and CO intoxication(2.5%).

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