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자근으로부터 acetylshikonin의 분리 및 함량분석
황석연,황방연,강삼식,김창민,박정일,배기환,손건호,이승호,장승엽,강신정,노재섭,이경순,Hwang, Suk-Yeon,Hwang, Bang-Yeon,Kang, Sam-Sik,Kim, Chang-Min,Park, Jeong-Hill,Bae, Ki-Hwan,Son, Kun-Ho,Lee, Seung-Ho,Chang, Seung-Yeup,Kang, Shin-Jung 한국생약학회 2000 생약학회지 Vol.31 No.3
Lithospermi Radix has been used in traditional medicine for antimicrobial, antiinflammatory, immunostimulating, antitumor and wound-healing activities. For the quality control of this drug, acetylshikonin was isolated from the hexane extract of Lithospermum erythrorhizon(Boraginaceae) and identified by the spectroscopic evidences. A quantitative analysis of acetylshikonin using HPLC method showed that the average contents were $0.084{\pm}0.026%$ in 31 samples collected throughout the various regions of Korea.
향부자의 성분 및 Nitric Oxide 생합성 저해효과
김선기,황방연,강신정,이정준,노재섭,이경순,Kim, Sun-Kee,Hwang, Bang-Yeon,Kang, Shin-Jung,Lee, Jung-Joon,Ro, Jai-Seup,Lee, Kyong-Soon 한국생약학회 2000 생약학회지 Vol.31 No.1
Five compounds were isolated from the methanol extract of the tubers of Cyperus rotundus (Cyperaceae). They were identified as cyperol(1), ${\alpha}-cyperone(2)$, cyperotundone(3), sugetriol triacetate(4) and ${\beta}-sitosterol(5)$ on the basis of spectroscopic and physicochemical analysis. Among them, cyperol, ${\alpha}-cyperone$ and cyperotundone were shown inhibitroy effects on LPS-induced nitric oxide production in RAW 264.7 cells in a dose dependent manner.
주혜경,황방연,안병태,김미정,최우회,조봉진,노재섭,이경순,Ju, Hei-Kyoung,Hwang, Bang-Yeon,Ahn, Byong-Tae,Kim, Mi-Jeong,Choi, Woo-Hoi,Cho, Bong-Jn,Ro, Jai-Seup,Lee, Kyong-Soon 한국생약학회 2000 생약학회지 Vol.31 No.3
Five compounds were isolated from the fruits of Evodia daniellii $H_{EMSLEY}$. Their structures were identified as 2-oxotridecanyl acetate, bergapten, limonin, squalene, ${\beta}-sitosterol$ on the basis of spectral data. Among these compounds, 2-oxotridecanyl acetate and squalene were isolated in this plant for the first time.
김민수,황방연,최상길,이명구,노재섭,이경순,Kim, Min-Soo,Hwang, Bang-Yeon,Choe, Sang-Gil,Lee, Myung-Koo,Ro, Jai-Seup,Lee, Kyong-Soon 한국생약학회 2000 생약학회지 Vol.31 No.4
From the alkaloidal fraction of the fructus of Chelidonium majus, two protoberberine alkaloids and one benzophenanthridine alkaloid were isolated. On the basis of chemical and spectroscopic evidences, the structures of these compounds were identified as chelidonine, coptisine and berberine.
김세은,황방연,김영호,김영중,이경순,이정준,Kim, Se-Eun,Hwang, Bang-Yeon,Kim, Young-Ho,Kim, Young-Choong,Lee, Kyong-Soon,Lee, Jung-Joon 한국생약학회 1997 생약학회지 Vol.28 No.4
Methanol extracts from 450 plants were screened for muttidrug-resistance reversing activity using drug sensitive KB-3-1 and multidrug-resistant KB-Vl cells. Among them, the extracts of Cynanchum wilfordii, Torilis japonica, Celastrus orbiculatus, Melia toosendan and Teminialia chebula strongly potentiated vinblastine cytotoxicity in KB-Vl cells. But their cytotoxicities to both sensitive KB-3-1 and resistant KB-Vl cells were in the same order of magnitude. These results indicate that the above samples would contain the active principles which do not exert their ativity solely by cytotoxicity.
Evodiamine의 Monoamine Oxidase 활성 저해작용
이상선,황방연,노재섭,이명구,Lee, Sang-Seon,Hwang, Bang-Yeon,Ro, Jai-Seup,Lee, Myung-Koo 한국생약학회 2006 생약학회지 Vol.37 No.4
The effects of evodiamine on monoamine oxidase (MAO) activity were investigated. MAO was purified from mouse brain and the $K_m\;and\;V_{max}$ values of MAO were $78.5{\pm}5.28{\mu}M$ and $0.68{\pm}0.07$ nmol/min/mg protein, respectively (n=4). Evodiamine at $30-120{\mu}M$ showed an inhibitory effect on MAO activity using a substrate kynuramine with an $IC_{50}$ value of $104.2{\mu}M$ (n=4). Evodiamine also exhibited a non-competitive inhibition on MAO. The $K_i$ value for evodiamine was $72.5{\pm}10.8{\mu}M$ (n=4). These results suggest that evodiamine partially contributes to the regulation of monoamine content.
정선채,황방연,오갑진,강신정,김미정,최우회,이경순,노재섭,Chung, Sun-Chae,Hwang, Bang-Yeon,Oh, Gab-Jin,Kang, Shin-Jung,Kim, Mi-Jeong,Choi, Woo-Hoi,Lee, Kyong-Soon,Ro, Jai-Seup 한국생약학회 1999 생약학회지 Vol.30 No.3
Seven compounds were isolated from the n-BuOH extract of the dried stem barks of Rhus javanica L. On the basis of physico-chemical, spectroscopic evidences and comparison with authentic samples, the compounds $1{\sim}7$ were identified as gallic acid (1), methyl gallate (2), scopoletin (3), scopolin (4), $1,\;2,\;3,\;4,\;6-penta-O-galloyl-{\beta}-D-glucose$ (5), orcinol (6) and $orcinol-{\beta}-D-glucoside$ (7). Among these compounds, scopolin, $orcinol-{\beta}-D-glucoside$ were isolated from this plant for the first time.
장현민,황방연,김민수,이동호,강신정,노재섭,이경순,Jang, Hyun-Min,Hwang, Bang-Yeon,Kim, Min-Soo,Lee, Dong-Ho,Kang, Shin-Jung,Ro, Jai-Seup,Lee, Kyong-Soon 한국생약학회 1998 생약학회지 Vol.29 No.3
Cornus controversa $H_{EMSL}$. (Cornaceae) is distributed widely in Korea and has been used for the treatment of diarrhea and a tonic medicine. Six compounds were isolated from the MeOH extract of the dried stem bark of Cornus controversa. Their structures were identified as gallic acid(1), scopoletin(2), arjunglucoside II(3), isoquercitrin(4), quercitrin(5) and rutin(6) by comparisons of the physicochemical and spectroscopic evidences. Among these compounds, scopoletin and arjunglucoside II were the first time isolation from this plant.
수치에 따른 숙지황 중의 5-hydroxymethyl-2-furaldehyde 함량분석
황석연,황방연,최우희,정한진,허재두,이경순,노재섭,Hwang, Suk-Yeon,Hwang, Bang-Yeon,Choi, Woo-Hoi,Jung, Han-Jin,Huh, Jae-Doo,Lee, Kyong-Soon,Ro, Jai-Seup 한국생약학회 2001 생약학회지 Vol.32 No.2
In order to determine the content of 5-hydroxymethyl-2-furaldehyde (5-HMF) in the Rehmanniae Radix Preparata, 5-HMF was isolated from the EtOAc fraction of the Rehmanniae Radix Preparata samples and identified by spectroscopic and physicochemical evidences. Twenty one samples prepared on the basis of increasing number of stewing times with wine were analyzed by HPLC. From this analysis, it was revealed that the samples processed under one to nine times of stewing showed increasing pattern in 5-HMF contents. And the samples processed under 9 to 18 times of stewing showed 0.53-0.74% in 5-HMF contents. However, for those samples processed more than 19 times, 5-HMF content profile showed decreasing pattern.