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식품중 발기부전 치료제 및 유사물질 함량에 관한 조사연구
홍해근(Hae-Geun Hong),방선재(Seon-Jae Bang),박광희(Kwang-Hee Park),이인숙(In-Sook Lee),박민정(Min-Jung Park),박정화(Jeung-Hwa Park),김종찬(Jong-Chan Kim) 대한환경위생공학회 2007 대한환경위생공학회지 Vol.22 No.3
To det ermine 8 anti-impotence drug/drug-like compounds such as sildenafil, vardenafil, tadalafil, homosildenafil, hydroxyhomosildenafil, aminotadalafil, pseudovardenafil and hongdenafil in foods, simultaneously, high performance liquid chromatograrhy(HPLC) and liquid chromatograthy-mass spectrometry (LC/MS) were used. The HPLC/UV analysis was performed on a column of capcellpak C₁? with 0,1 % sodium-1-hexansulfonate in 0.2M ammonium formate/acetonitrile as a mobile phase. Mass spectra of the compounds by LC/MS were investigated with SCAN mode(Mass range and Fragment voltage) and SIM (Selected Ion Monitoring) mode (Ion target and Fragment voltage). The results follow as; 1. The HPLC/UV analysis was detected from 5 out of 63 samples. The content of sildenafil was in the range of 32.80 ppm~60,13 ppm from 4 out of 5 samples, The contents of sildenafil, vardenafil, homosildenafil were in the range 47,14 ppm from lout of 5 samples. 2. The conformed result of LC/MS was equal of detected from 5 out of 63 samples in HPLC/UV analysis. An easily available, simultaneous determination of 8 standards in adulterated health related foods was established by using a combination of LC/MS methods.