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Differentiation of fibroblast through NGF by uniaxial tension
Mina Kim(김미나),J.W. Hong(홍정우),Minsoo Nho(노민수),Yong Joo Na(나용주),Jennifer H. Shin(신현정) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.11
Mechanical tension plays an important role in the homeostasis of connective tissue fibroblast. Differentiation of fibroblast to myofibroblasts is related to late stage of wound healing process, stimulating fibroblast to produce collagen. Previous studies have shown that the external NGF induces a-SMA expression in conjunctival fibroblasts through TGF-β1. Our previous data shows that both NGF and TGF transcription exhibit tensile stress dependent behavior which could lead to enhancement of wound healing. We investigate the effects of uniaxial tensile stress on the expression of a-SMA, distinction between fibroblast and myofibroblast, through increase of NGF. Uniaxial tension lead to a-SMA express on the fibroblast and external NGF and TGF treatment induces stress fiber containing α-SMA. Our results may imply that the induction of a-SMA is a consequence of regulation of NGF and TGF by uniaxial tension in fibroblasts.
다양한 PC 클러스터 시스템 환경에서 CFD 코드의 성능 분석
조금원(K. W. Cho),홍정우(J. Hong),이상산(S. Lee) 한국전산유체공학회 2001 한국전산유체공학회지 Vol.6 No.2
In recent years cluster systems using off-the-shelf processors and networks components have been increasing popular. Since actual performance of a cluster system varies significantly for different architectures, representative in-house codes from major application fields were executed to evaluate the actual performance of systems with different combination of CPU, network, and network topology. As an example of practical CFD(Computational Fluid Dynamics) simulations, the flow past an Onera - M6 wing and the flow past an infinite wing were simulated on clusters of Linux and several other hardware environments.