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홍대기 ( Dae Gy Hong ),( Eun Hee Kim ),( Joo Young Kim ),( Yoon Hee Lee ),( Gun Oh Chong ),( Ji Young Park ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-
Objective: This study was aimed to compare immunohistochemical expression of estrogen receptor (ER)a, progesterone receptOf (PR), and calponin in gonadotrophin-releasing horrrone agonist (GnRH-a)-sensilive and -resistant uterine fibroids. Methods: We collected data retrospectively. The sensitive group consisted of women who had reduction in uterine volume greater than 40% following GnRH-a treatment. Uterine volume was either reduced by less than 10%, or was increased in the resistant group. A tissue microarray was constructed using formalin-fixed, paraffin-embedded tissues, 31 and 26 patients for the sensitive and resistant groups, respectively. Tissue sections were immunostained with antibodies against ER-a, PR. and calponin. The intensity and area of the immunohistochemical reactions were evaluated using a semi-quantitative scoring system. The Mann-WhitneyU-test, Fisher``s exact test. and Spearman``s rank correlation test were used for analysis of data. Results: PR (P= 0.04) and calponin (p= 0.03) showed a significantly higher staining intensity in the resistant group than in the sensitive group. Both groups showed comparable expression of ER-a (P = 0.23). In correlation analysis between changes in uterine volume after GnRH-a therapy and clinicopathological factors, the immunohistochemical intensity 01 PR (P= 0.04) 2nd calponin (P= 0.03) was significantly correlated with changes in uterine volume. Conclusion: This study shows that GnRH-a resistance of uterine fibroids is not related to ER-a content. but the expression of PR and calponin is related with GnRH-a resistance.
자궁내막 샘근육종 폴립을 동반한 Peutz-Jeghers 증후군
이윤희 ( Yoon Hee Lee ),홍대기 ( Dae Gy Hong ),배지혜 ( Ji Hae Bae ),박내윤 ( Nae Yoon Park ),정근오 ( Gun Oh Chong ),이윤순 ( Yoon Soon Lee ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.2
Peutz-Jeghers syndrome, which has autosomal dominant inheritance, shows pigmentation in lip and skin. It also has features of harmatomatous polyp over the gastrointestinal tract, while sometimes developing tumor in genital tract. Known tumors in female genital tract include cervical adenocarcinoma, sex cord tumor, etc. Adenomyomatous polyp in uterus is also one of the rare diseases, which seldom develop in the absence of hormone treatment such as Tamoxifen. Currently, there is one case of Peutz-Jeghers syndrome patient with endometrial adenomyomatous polyp. Authors found mole-like lesions on the transvaginal ultrasonogram in a typical Peutz-Jeghers syndrome patient without pregnancy history and previous chemotherapy. After confirming its diagnosis of adenomyomatous polyp on resectoscopic biopsy, we report our findings along with brief literature review.
성원준 ( Won Joon Seong ),오정은 ( Jeong Eun Oh ),이윤희 ( Yoon Hee Lee ),홍대기 ( Dae Gy Hong ),이택후 ( Taek Hoo Lee ),이윤순 ( Yoon Soon Lee ),박일수 ( Il Soo Park ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.7
목적: 본 연구는 IgA 신병증이 병합된 임신에서 산모와 태아의 예후를 알아보고, 임신의 합병증과 관련된 예후인자를 찾기 위함이다. 연구 방법: 1997년에서 2006년 사이에 본원에서 조직검사상 IgA 신병증으로 진단받은 여성 가운데 14명의 산모에서 발생한 20예의 임신을 대상으로 하였다. 이 중 분만한 17예의 산모를 대상으로 내과, 산부인과 및 신생아 의무기록과 검사 소견을 후향적으로 조사하여 통계 분석하였다. 결과: 20예의 임신 중 자연유산이 3예이었고 17예에서 생존아를 분만하였다. 47%에서 중증 자간전증, 53%에서 저출생체중아가 발생하였고, 59%에서 37주 이전에 조산하였다. 그러나 조산의 대부분은 34주 이후에 발생하였고 신생아는 모두 생존하였다. 임신 전에 비하여 분만 후에 혈압의 유의한 상승이 관찰되었다. 결론: IgA 신병증 환자에서 임신은 금기는 아니지만 자간전증, 조산 및 저출생체중아의 빈도가 증가하므로 고위험 임신에 준한 면밀한 산전관리가 요구된다. Objective: We performed this study to evaluate maternal and fetal outcomes of pregnancies with IgA nephropathy. Methods: We reviewed 20 pregnancies occurred in 14 women who were diagnosed as IgA nephropathy with the method of renal biopsy between 1997 and 2006. We used clinical and laboratory data from medical records and statistic analysis using SPSS 15.0. Results: Of 20 prenancies, there were 17 live births and 3 spontaneous abortions. There was no stillbirth and congenital anomaly. We found severe preeclampsia in 47%, low birth weight in 53% and preterm birth (comprising medical indications) in 59%. But most were late preterm birth and all were alive. Blood pressure was elevated after delivery compared with pre-pregnancy. Conclusion: Although pregnancy is not contraindicated in IgA nephropathy, it is associated with significant complications comprising preeclampsia, preterm birth and low birth weight.