반응성 천공성 교원증

이증훈(Jeung Hoon Lee),현종명(Jong Myung Hyun) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.6

Reactive perforating collagenosis, first described by Mehregan et al in ]967, is a skin disorder characterized by transepidermal eliniination of altered collagen fibers. This rare disease appears as recurrent, umbilicated, crusted papules in response to minor trauma. We report here a case of reactive perforating collagenosis in a 21-year-old man. Examination of the skin revealed a number of centrally umbilicated, asymptomatic papules filled with keratotic plugs in various development and regression. The lesions were distributed on the dorsa of the hands, face, and neck. The biopsy spccimen showed a few of thin bundles of collagen which v ere extruded from the dermis through the atrophic epidermis and the turinels within the epidermis, reaching the buttom of the plug.

표피 과형성을 보이는 질환의 Glycogen에 관한 연구

장인성(In Seong Jang),현종명(Jong Myung Hyun),김수남(Soo Nam Kim) 대한피부과학회 1984 大韓皮膚科學會誌 Vol.22 No.4

In order to assess the epidermal glycogen in the epidermal hyperplastic disease, PAS(Periodic Acid Schiff) stain with or without diastase is used. Epidermal PAS positive reaction is significantly increased in psoriasis (90. 0%), verruca vulgaris (100%) and lichen simplex chronicus (100%) than control group (12, 5%) Epidermal PAS positive reaction is relatively increased in prurigo nodularis(66. 7 %) and chronic contact dermatitis (75%) Strong PAS positive reaction is noticed in 3 of 5 cases (60%) with verruca vulgaris, but none of 22 cases with psoriasis. It is suggested that epidermal glycogen epidermal hyperplasia and that the more glycogen accumulated. than control group (12. 5%) in 3 of 5 cases (60%) with verruca vulaccumulation is accompanied with the hyperplastic the epidermis is, the more glycogen accumulated.

편측성 모반양 혈관확장증 2예

장인성(In Seong Jang),서원필(Weoun Pheel Seo),김지호(Ji Ho Kim),현종명(Jong Myung Hyun),이현우(Hyun Woo Lee),이유신(Yoo Shin Lee) 대한피부과학회 1983 대한피부과학회지 Vol.21 No.5

Unilateral nevoid telangiectasia is a rare but clinica.lly distinct dermatosis first deacribed by Zeisler in 1922. It had been also called as linear telangiectasia or unilateral telangiectasia. Wilkin suggested the term unilateral dermatomal superficial telangiectasia, in 1977. There are some reports of congenital unilateral nevoid telangiectasia but it usually occurs in women during the puberty and the third decade. Clinically it is characterized by superficial telangiectatic lesions distributed along the dermatomes uniIaterally and usually on the upper part of the body. It was reported that unilateral nevoid telangiectasia was related with elevated serum estrogen level in the many cases. We present two patients, 23-year and 25-year-old male soldiers, whose leaions were consistent with unilateral nevoid telangiectasia elinically and histopathologically.

Frey 증후군 ( Auriculotemporal syndrome )

서원필(eon Pheel Seo),장인성(In Seong Jang),현종명(Jong Myung Hyun),김두한(Doo Han Kim),김홍직(Hong Jig Kim),김판식(Pan Sik Kim) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.1

Frey syndrome is characterized by sweating and flushing on the auriculotemporal region in respense to gustatory stimuli following surgery, trauma or irfection of the parotid areas. A 22-year-old man had received a surgery for sclerosis and hypertrophy of the left mandible. Two months after operation gustatory sweating occurred, whenever he eats, on the malar area without any detectable flushing or sensory impairment. Sweating starts in 30 seconds during food intake and is clearly visible with naked eyes within 2 minutes. This syndrome is encountered uncommonly to the dermatologic practitioners but more cases might be discovered if more attention could be given to this condition.

전이성 악성흑색종

장인성(In Seong Jang),천영일(Young Il Chun),김광중(Kwang Joong Kim),이병호(Byung Ho Lee),현종명(Jong Myung Hyun) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.2

We present a case of metastatic mailgnant melanoma developed in the 40 year- old male patient. Six month prior to visit to our department of dermatology, the patient found an egg sized mass covered with normal skin on his right inguinal area, which showed typical findings of the metastatic malignant melanoma histopathologically. The primary malignant melanoma on the right shin was removed by wide surgical excision at 18 months prior to visit to our department of dermatology.

下肢의 炎症性結節에 對한 免疫病理學的 硏究

玄鍾鳴,金秀男 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.1

During the past decades numerous attempts to make a reasonable classification of the diseases manifesting themselves as nodules of the legs have been made, but none of the classifications has been generally accepted. The development of the immunohistological method as a diagnostic aid has shed more light on the pathogenesis of these diseases. Yet, the results have been very confusing, not in the least owing to the different clinical and histological diagnostic criteria used. This study is an effort to compare both histological and immunohistological findings with clinical data compiled on nodular diseases of the legs. Twenty four patients who gave a clinical impression of erythema nodosum and/of erythema induratum and 10 patients who have been diagnosed as erythema nodosum leprosum were included in this study. Without any prior knowledge of the clinical data and histological diagnosis, the patterns of immunological reaction were studied by avidin biotin peroxidase complex( A B C) method of immunoperoxidase technique and were divided into five groups. These results were compared with the histological diagnosis and the clinical data. The results are as follows: 1. Histological diagnosis showed that out of 24 subjects, there were 10 cases of erythema nodosum. None of these cases revealed deposits of immunoglobulins(G, A and M), C₃ and fibrin in and around the dermal blood vessels. 2. Histologically 14 among 24 subjects were diagnosed as erythema induratum. In 11 of the 14 cases, immunoglobulins were found in the blood vessel and the fat tissue around the vessels. C₃ was positive in 2 cases and fibrin in 9 cases. 3. All 10 cases of erythema nodosum leprosum, revealed deposit of immunoglobulins in and around the dermal blood vessels. Seven cases showed deposit of immunoglobulins in the dermo-epidermal junction, endothelium of dermal blood vessels and inflammatory cells around the vessels and the appendages. C₃ was found in 4 cases and fibrin in 5 cases 4. In a comparison between 5 cases of tuberculous type and 9 cases of non-tuberculous type of erythema induratum there were no difference in the histological findings and patterns of immunogrobin deposits. These results suggest that the pathomechanism of erythema induratum and erythema nodsum leprosum in this study represents the Arthus reaction, but not of erythema nodosum. The histological criteria used in this study corresponded well with the immunohistological findings.

수종국산화장품이 좌창발생에 미치는 영향에 관한 실험적(實驗的) 연구

김수남,현종명 대한피부과학회 1978 大韓皮膚科學會誌 Vol.16 No.4

Varioua articles have been reported that extemal contactants were the cause Acne venenata. The daily use of cosmetics are tbe cause of Acne minor in adult wamen. To distinguish this from other type of Acne venenata due to extemal contactants Kligman had coined the term Acne cosmetica, which is a low grade persistant acneiform eruption with occasional papulopustulea in adult women. The authors have tested a wide range of available cosmetics(Total twenty including four kinds of cold cream species, two of cleansing cream species, three of nutrient cream species, six of lotion species, three of foundation make up species and two of foreign cosmetics) using the rabbit ear assay recently popularized by Kligman in order to evaluate comedogenic effects of various Korean cosmetics. The results a.re as follows. 1. Among these twenty facial cosmetics, We observed no comedogenccicy in two facial cosmetics, mildly comcdogenecity in twelve facial cosmetics, moderately comedo- genecity in four facial cosmetics and severe comedogenecity in two facial cosmetics. 2. Histologic gradings were paralleled the findings of tbe naked eye in up to 65% 3. There were significant differences on comedogenecity between Korean cosmetics and foreign cosmetics which used by Kligman. 4. There were no significant diffrences between cold cream species, cleansing cream species. nutrient, cream species, lotion species and foundation make up species. 5. There were various differences among twenty kinds of every cosmetic species.

Epidermolysis Bullosa Dystrophica 의 1 예

이난희,김진택,현종명 대한피부과학회 1977 大韓皮膚科學會誌 Vol.15 No.3

A case of Epidermolysis Bullosa Dystrophica is reported with review of pathogenesis with literatures. Epidermolysis Bulloaa Dystrophica is a rare genetic disease which is characterized by the formation of blister upon the minor trauma or friction to the skin. A 7-year old boy was referred to our dept. in Aug. 1976 because of a severe bullous eruption primarily on his hands and feet. On admission tense bullae were noted on the dorsa of hands and feet which is usually serous but may be hermorhagic tendency. Soon thereafter tbis bullous lesion tend to break down into painful shallow denudation which may leave depigmented scars and milia after healing. Family history was negative for skin disorders.

수종 피부질환에 대한 Frason 의 임상적 경험

박양자,김진택,이란희,현종명 대한피부과학회 1977 大韓皮膚科學會誌 Vol.15 No.2

Esperson', a new topical steroid ointment containing 0. 05% 17-Desoxymethasone,. was used in several kinds of dermatoses. Framycetin which was isolated and uientified by the research organisation of Roussel Laboratories (SOFRAPEN) in 1950 from culture broths of a strain of Streptomyces species is a wide spectrum antibiotics on various bacterial infectious diseases. Total 50 patients including 10 cases of 2ndary infected Atopic dermatitis, 10 of infected Contact dermatitis, 6 of infected Seborrheic dermatitis, 7 of infected Neurodermatitis, 3 of infected Chronic dermatitis, 5 of lmpetigo, 2 of infected Nummular eczema, 2 of infected Infantile ecze;na, 1 of infected Intertrigo, 1 of Eczematoid Otitis extema, 1 of 2nd degree Bum, 1 of infected Pruritis ani, 1 of infeeted 1nsect bite. were treated with Frason (0.05% 17-desoxymethasone & 0.5% Framycetin combination). Among these 50 patiants, we observed excellent effects in 7 patients (14%), good effect in 29 patients (58%), fair effect in 10 patients (20%), Totally 36 patients (72%) revealed excellent to good therapeutic effects on their skin conditione after unoccluded application of Frason^ⓡ. 3 times daily for about 14 days. There was no sid ffect in all subjects after application of Esperson-F.