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Methemoglobinemia development after ingestion of a chinese herbal medicine: A case report
현세은,남경필,유은경,한만용,황필주 대한소아청소년과학회 2009 Clinical and Experimental Pediatrics (CEP) Vol.52 No.3
An 8-year-old girl visited the emergency room with perioral cyanosis and dyspnea, which had developed 20 hrs prior to the hospital visit. She had taken a Chinese herbal medication for 3 days prior to the onset of the symptoms. A co-oximeter examination revealed a methemoglobin level of 23.7%. An intravenous infusion of methylene blue was administered. Chemical analysis of the herbal medication revealed an ammonia (NH3) level of 239.41 mg/L. More studies are needed on the correlation between methemoglobinemia and the components of Chinese herbal medicines.
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집먼지 진드기 항원을 이용한 초급속면역치료의 안전성과 효과
현세은,김형윤,곽지희,신윤호,서지영,한만용 대한소아청소년과학회 2008 Clinical and Experimental Pediatrics (CEP) Vol.51 No.8
Purpose:Immunotherapy is accepted as the only treatment of allergic disease that can modify the natural course of the disease and ameliorate symptoms. This study aimed to evaluate the safety and efficacy of ultra-rush therapy using Dermatophagoides extracts in children. Methods:Of children older than four years who had visited Bundang CHA Pediatric Allergy Clinic, those showing positive reactions only to Dermatophagoides in the skin prick test and to the nasal provocation test were included. In all, 11 and 12 patients respectively preferred conventional and ultra-rush immunotherapy. We elevated allergen concentrations diluted to 1,000:1 of the end strength by 2-3 times with 30-minute intervals and checked oxygen saturation, pulse rate, blood pressure, and systemic reactions every 15 minutes. Immunotherapy effectiveness was valued by changes in nasal provocation test scores before and after immunotherapy. Results:The average ages of patients in the conventional and ultra-rush immunotherapy groups were 8.3±2.3 and 9.2±2.8 years, respectively. Systemic reactions were observed in six in the ultra-rush group (50%) without anaphylaxis and one (9%) in the conventional group. The average scores in the nasal provocation test before and after treatment in the conventional group were 8.2±1.5 and 4.6±2.1, respectively (P=0.043). In the ultra-rush immunotherapy group, the scores changed from 6.2±2.2 to 3.7±2.5 (P=0.017). Conclusion:Ultra-rush immunotherapy using Dermatophagoides in children is effective for treating allergic disease but can induce systemic effects rather than conventional immunotherapy. (Korean J Pediatr 2008;51:868-873) Purpose:Immunotherapy is accepted as the only treatment of allergic disease that can modify the natural course of the disease and ameliorate symptoms. This study aimed to evaluate the safety and efficacy of ultra-rush therapy using Dermatophagoides extracts in children. Methods:Of children older than four years who had visited Bundang CHA Pediatric Allergy Clinic, those showing positive reactions only to Dermatophagoides in the skin prick test and to the nasal provocation test were included. In all, 11 and 12 patients respectively preferred conventional and ultra-rush immunotherapy. We elevated allergen concentrations diluted to 1,000:1 of the end strength by 2-3 times with 30-minute intervals and checked oxygen saturation, pulse rate, blood pressure, and systemic reactions every 15 minutes. Immunotherapy effectiveness was valued by changes in nasal provocation test scores before and after immunotherapy. Results:The average ages of patients in the conventional and ultra-rush immunotherapy groups were 8.3±2.3 and 9.2±2.8 years, respectively. Systemic reactions were observed in six in the ultra-rush group (50%) without anaphylaxis and one (9%) in the conventional group. The average scores in the nasal provocation test before and after treatment in the conventional group were 8.2±1.5 and 4.6±2.1, respectively (P=0.043). In the ultra-rush immunotherapy group, the scores changed from 6.2±2.2 to 3.7±2.5 (P=0.017). Conclusion:Ultra-rush immunotherapy using Dermatophagoides in children is effective for treating allergic disease but can induce systemic effects rather than conventional immunotherapy. (Korean J Pediatr 2008;51:868-873)
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