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- 저자 : 허애영 ( Ae Young Her ) (검색결과 5 건)
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증례 : 비소세포 폐암과 합병된 Wegener 육아종증 1예
허애영 ( Ae Young Her ),이희영 ( Hui Young Lee ),강구 ( Gu Kang ),송서영 ( Seo Young Song ) 대한내과학회 2007 대한내과학회지 Vol.73 No.3
저자 등은 객혈, 호흡 곤란을 주소로 내원한 70세 여자 환자에서 비소세포 폐암과 합병되어 눈, 코, 부비동, 신장 등을 침범한 Wegener 육아종증 1예를 경험하였고 이에 대한 국내의 보고가 드물기에 문헌고찰과 함께 보고하는 바이다. Vasculitis may be a manifestation of the paraneoplastic syndrome in association with solid and hematological cancers. There are few reports of paraneoplastic antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis in patients with solid tumors. Wegener`s granulomatosis is a systemic vasculitis characterized by necrotizing granulomatous vasculitis of the upper and lower respiratory tracts together with glomerulonephritis and are ANCA-positive. We experienced a case of Wegener`s granulomatosis complicated by non-small cell lung carcinoma (NSCLC) and we report this case with a brief review of the literature.(Korean J Med 73:336-341, 2007)
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말기신부전 환자에서 혈중 Adiponectin과 심혈관 질환
이희영 ( Hui Young Lee ),허애영 ( Ae Young Her ),최동욱 ( Dong Wook Choi ),박명옥 ( Myoung Ok Park ),백현정 ( Hyun Jeong Baek ),정해혁 ( Hae Hyuk Jung ) 대한내과학회 2006 대한내과학회지 Vol.71 No.6
목적: 지방조직에서 유래하는 adiponectin은 인슐린 감수성 및 항염증의 특성이 있고. 심혈관 질환의 발생억제와 연관되어 있는 것으로 알려지고 있다. 그러나 심부전이나 신장질환과 같은 만성소모성 질환이 있는 환자들에서는 그 연관이 뚜렷하지 않고 논란이 있다. 본 연구는 유지 혈액투석 중인 말기신부전 환자에서 adiponectin의 혈청 농도와 심혈관 질환 위험/예측인자들과의 관련성을 알아보고자 하였다. 방법: 유지 혈액투석 중인 48명의 성인 환자를 대상으로 adiponectin과 leptin의 혈청 농도를 측정하였다. 또한 심혈관생화학지표인 B-type natriuretic peptde (BNP), cardiac troponin T (cTnT) 등을 측정하고 심혈관 질환의 병력을 조사하여 지방세포 호르몬과의 관계를 알아보았다. 결과: Adiponectin의 혈청 농도는 HDL-cholesterol (r=0.456, p=0.001), triglyceride (r=-0.528, p<0.001) 및 leptin (r=-0.427, p=0.002)의 혈청 농도와 유의한 상관관계를 보였고, 체질량지수(r=-0.326, p=0.024)와 음의 상관관계를 보였다. 심혈관지표 중 BNP는 adiponectin (r=0372. p=0.009)과 양의 상관관계가 있었고, 체질량지수(r=-0.310, p=0.032)와 음의 상관관계가 있었으며, cTnT는 adiponectin (r=0.276, p=0.058)과 유의하지는 않으나 양의 상관성을 보였다. 과거 심혈관 질환의 병력이 있는 군(n=20)이 없는 군에 비해 체칠량지수 (p=0.026)는 더 낮고 BNP (p=0.017)와 cTnT (p=0.012)가 더 높았으나, adiponectin은 두 군 간에 유의한 차이를 보이지 않았다. 결론: 말기신부전 환자에서 고 adiponectin 혈증은 양호한 혈증 지질 농도와 관련이 있었으나, 심혈관 질환병력과 직접적인 관계가 없었고, 오히려 심혈관 질환의 위험인자였던 BNP의 증가 및 체질량지수의 감소와 연관이 있었다. 따라서 말기신부전 환자에서 adiponectin은 일반인과는 다르게 심혈관 질환 발생에 복잡한 역할을 할 것으로 생각되며 이에 대한 추가 연구가 필요할 것이다. Background: Adiponectin is a fat-based protein that alters the insulin sensitivity, has anti-inflammatory properties, and reduces the incidence of cardiovascular disease (CVD). However, this connection is unclear in patients with chronic wasting disease, such as heart failure or end-stage renal disease (ESRD). Therefore, this study examined the relationship between adiponectin and the cardiovascular risk/predictive factors in ESRD patients. Methods: The serum concentrations of adiponectin and leptin were measured in 48 adult patients on maintenance hemodialysis. In addition, the blood levels of B-type natriuretic peptide (BNP) and cardiac troponin T (cTnT) as cardiovascular biomarkers were measured, and the CVD history was reviewed in order to determine if there was any correlation with adiponectin. Results: There was a significant correlation between the adiponectin levels and the serum concentrations of HDL-cholesterol (r=0.456, p=0.001), triglyceride (r=-0.528, p<0.001), and leptin (r=-0.427, p=0.002) and an inverse correlation with the body mass index (BMI) (r=-0.326, p=0.024). The BNP levels were positively correlated with the adiponectin concentrations (r=-0.372, p=0.009) and negatively correlated with the BMI (r=-0.310, p=0.032), and there was a slight positive correlation between cTnT and adiponectin (r=0.276, p=0.058). Patients with a history of CVD had higher levels of cTnT (p=0.012) and BNP (p=0.017), and a lower BMI (p=0.026) than patients without such a history. There was no significant difference in the adiponectin levels between the two patient groups. Conclusions: A higher adiponectin level is related to a favorable lipid profile. However, adiponectin is not directly associated with a history of CVD, and there was a correlation between a higher adiponectin level and a higher BNP and lower BMI, which are cardiovascular predictive factors, in ESRD patients. However, further research with more patients will be needed to properly determine the complicated relationship between adiponectin and the development of CVD. (Korean J Med 71:646-653, 2006)
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박찬우,옥택근,조준휘,최동욱,허애영,이희영,김용훈,조병렬,김성은,최기훈,배지훈,서정열,정재봉,Park,, Chan-Woo,Ok, Taek-Gun,Cho, Jun-Hwi,Choi, Dong-Wook,Her, Ae-Young,Lee, Hee-Young,Kim,, Yong-Hoon,Cho, Byung-Ryul,Kim,, Sung-Eun,Choi, Ki-Hoon 대한임상독성학회 2004 대한임상독성학회지 Vol.2 No.1
With a recent well-being boom, our interest in chemical-free vegetables is also increasing. So, some people are trying to take in wild plants chosen by themselves. However, others often come to their rescue in an emergency department after eating them, caused by their misunderstanding poisonous herbs as edible vegetables. We have ever seen two persons carried into the emergency department with bradycardia and shock incurred by his intake by confusion between Caltha palustris and Ligularia fischeri lately. There were symptoms such as epigastric pain, nausea, vomiting and so on in their cases, and the symptoms of bradycardia and hypotension continued. Owing to sustained bradycardia and hypotension states, we applied a dopamine to a patient, and then the in-patient left the hospital two days later. We presumed the cause of the two symptoms appeared in two cases to be a saponin in Caltha palustris. For that reason, if someone has the bradycardia and hypotension symptoms from an unknown cause after taking in wild plants, they have to consider a toxication by the Caltha palustris. Therefore, this paper focused on the issue that unexpected poisoning would have to be prevented by studying about wild plants much more and informing the toxic risk from the plants.
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심부전과 과다호산구증가증으로 내원한 PDGFRB 유전변이가 동반된 골수성 종양
권재우 ( Jae-woo Kwon ),권지현 ( Ji-hyun Kwon ),허애영 ( Ae-young Her ) 대한천식알레르기학회(구 대한알레르기학회) 2017 Allergy Asthma & Respiratory Disease Vol.5 No.4
Hypereosinophilic syndrome (HES) is a heterogeneous disorder characterized by persistent hypereosinophilia with the evidence of organ dysfunction caused by eosinophilic involvement. HES can be induced by various secondary causes, including helminthic in fections, adverse drug reactions, and allergic diseases. Primary/clonal bone marrow disease, including genetic mutations in platelet driven growth factor receptor alpha (PDGFRA), platelet driven growth factor receptor beta (PDGFRB), and fibroblast growth factor receptor 1 (FGFR1) could be its causes. Although corticosteroids are the mainstay of therapy in confirmed HES, imatinib is consid ered a definitive treatment for HES with these mutations. However, there have been few reports about HES with these genetic mu tations in Korea. Here, we report a patient who presented with sudden onset of congestive heart failure and hypereosinophilia, proved to have PDGFRB rearrangement, and was controlled successfully with imatinib after left ventricle thrombectomy. (Allergy Asthma Respir Dis 2017;5:232-236)
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