청소년기와 성인기 여드름의 임상 양상 및 여드름에 관한 인식도의 비교 분석

함정희(Jeong Hee Hahm),강민정(Min Jung Kang) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.5

N/A Background:Acne has been recognized as a common disorder of adolescence but recent studies have documented increased prevalence of post-adolescent acne. Objective:The purpose of this study is to evaluate and compare the clinical features and subjective concepts about aggravating factors in adolescent and post-adolescent acne. Methods:367 patients who visited the department of Dermatology, Ewha Womans University Hospital from November, 1998 to February, 1999 were studied. 193 of the patients were below the age of 22(adolescent group) and 174 above the age 25(post-adolescent group). Results:1. In the predominant sites in the face, jaw and perioral area more common in post-adolescence than in adolescence. 2. Major acne types were papulopustular, comedonal and cystic with decreased order of frequency in both age groups, and cystic acne was more common than comedonal in male population in both groups. The severity of acne is worse in adolescence than in post-adolescence (p<0.05). 3. Facial acne scar was found in 85% of adolescence and 90% of post-adolescence. Ice-pick, macular atrophic, hypertrophic, keloidal and follicular elastolytic scars were involved in decreased order in both groups. The severity of acne scar in post-adolescence was not significantly higher than that of adolescence(p>0.05). There was significant positive correlation between severity of scar and duration of acne in both groups(r=0.19 and r=0.23, p<0.05). 4. Among the post-adolescent group, 30% presented with late-onset and the features of hyperandrogenism were more commoly associated in post-adolescent female patients(39%) than adolescent(33%). 5. Aggravating factors in the post-adolescence were more commonly noted in the use of cosmetics, occupation and certain food, while in the adolescence, physical fatigue, psychologic stress, excessive sweating and sun exposure were. 6. 34% of adolescence and 71% of post-adolescence had history of medical intervention. The rate of non-responsive and relapsed acne after one or more cycle of oral medication within one month was higher in post-adolescence(59%) than in adolescence(38%).Conclusion:Compared with adolescent patients, post-adolescent patients were characteristically more commonly associated with features of hyperandrogenism and resistance to one or more cycles of oral medication and aggravating factors of acne were more closely related to the occupations including chronic exposure to materials and use of cosmetics. Female post-adolescent patients who were presented with late onset acne, were resistant to treatments or with features of hyperandrogenism should be carefully studied for abnormalities of the ovarian, adrenal or local androgen metabolism. (Korean J Dermatol 2000;38(5):589~599)

Mohs 미세도식 수술 및 쌈지봉합 복원술을 이용한 융기성 피부섬유육종의 치험

최유원,황규광,함정희,이정복,Yoo Won Choi,Kyu Kwang Whang,Jeong Hee Hahm,Jung Bock Lee 대한피부과학회 1995 대한피부과학회지 Vol.33 No.6

Dermatofibrosarcoma protuberans is an uncommon, locally aggressive fibroblastic tumor, characterized by infrequent metastasis and a marked tendency of local recurrence after excision. Histologically, it shows large uniformed spindle shaped cells arranged in a cartwheel or storiform pattern. We report a case of dermatoribrosarcoma protuberans on the lower abdomen of a man aged of thirty, treated with Mohs micrographic surgery and purse-string suture repair. (Kor J Dermatol 1995;33(6): 1108-1113)

문신 제거에 사용한 Alexandrite 레이저의 효과

강호정 ( Ho Jung Kang ),박혜진 ( Hae Jin Park ),함정희 ( Jeong Hee Hahm ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.5

Background: Until the recent development of the Q-switched lasers, it was impossible to remove tattoos without causing scarring and sometimes disfiguring. Variations in wavelengths and pulse widths may result in different clinical effects or risks, Objectiye : The purpose of this study was to investigate the therapeutic effects of the alexandrite laser in removing t;ttoos clinically, histologically and ultrastructually. Methods . Fourty-two patients with gray, black, and blue-black colored tattoos were treated with fluences ranging from 6.5 to 8.0 J/crt1 at a minimal interval of 6 weeks. We took pictures of each tattoo prior to treatment and each treatment session in order to evaluate clinical irnprovement. Biopsy specimens were obtained from 8 patients, on prearranged times.' before, immediately after, one week after an3 6 weeks after irradiation. Results . The results if the treatment of 42 patients with tattoos were analyzed. After two treatment sessions, 89% of patients showed 51% to 95% improvement. Transient hyperpigmentation and hypopigmentation occurred in 7 patient.s. However, skin atrophy, hypertrophic scar or infection did not occur. Ir a biopsy specimen taken 6 weeks after irradiation on light microscopy, most of tattoo granules disappeared without collagen fiber change. However, macrophage engulfing t,attoo granules and a minute amount of tattoo granules still remained in the dermis on electron microscopy, Conclusion : The .alexandrite laser is considered to be a safe and effective treatment rnodality for removal of gray, black, and blue-black tattoo pigments. (Kor J Dermatol 1996;34(5): 790-796)

동정맥 혈관종 3예

김문정(Moon Jung Kim),신나라(Na La Shin),조소연(So Yun Cho),황규광(Kyu Kwang Whang),함정희(Jeong Hee Hahm) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.4

We experienced three cases of arteriovenous hemangioma in middle-aged patients. Each of them an asymptomatic small red to purple papule on the face and arm, which showed typical microscopic features of proliferating variously sized vessels in the dermis. An interesting finding was the increased number of mast cells identified in the stroma and perivascular channels, which may be associated with angiogenesis in inflammatory and neoplastic processes. Although arteriovenous hemangioma has been reported infrequently, its true incidence is considered to be higher than expected. Thus biopsy should be performed for exact diagnosis of small vascular lesions. (Korean J Dermatol 2000;38(4):506~511)

피부 기관지원성 낭종

강민정(Min Jung Kang),신나라(Na La Shin),조소연(So Yun Cho),함정희(Jung Hee Hahm) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.8

N/A

포진상 농가진

강호정(Ho Jung Kang),함정희(Jeong Hee Hahm) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.2

A case of impetigo herpetiformis occurring in a 25-year-old multigravida woman is reported. Superficial grouped pustules on an erythematous base developed on the flexual areas of both extremities and disseminated all over the body with mild pruritus, fever and burning sensation at her 14th weeks of pregnancy. Histopathologic findings showed acanthosis and subcorneal. pogiform pustule. All lesions had gradually improved within 2 weeks after artificial abortior. Our case demonstrates the characteristic features of impetigo erpetiformis, as compared with pustular psoriasis. This, we emphasize the need to preserve it as a separate entity. (Kor J Dermatoi 1992;30(2): 229-233)

Acute Generalized Exanthematous Pustulosis

박혜진,강호정,함정희 ( Hae Jin Park,Ho Jung Kang,Jeong Hee Hahm ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.1

Acute generalized exanthematous pustulosis(AGEP) has symptoms of abrupt onset of a widespread pustular eruption on an erythematous. base. Most cases appear to be related to drug reactions, mainly antibiotics, but viral infections and hypersensitivity to mercury may cause AGEP. The essential features of AGEP include. (1) numerous(several dazen) small((5mm), mostly non follicular pustules arising on a widespread erythema:purpura and target-like lesions may be associated; (2) histology showing intraepidermal or subcorneal pustules associated with one or more of the following.clermal edema, vasculitis, perivascular eosinophils, or focal necrosis of keratinocytes; (3) fever (over 38C); (4) neutrophilia, and (5) acute evolution with spontaneous resulotion of pustules within 15 days. We report a case of AGEP which presented with widespread tiny pustules on the whole body except the face, palms and soles. There were petechia, purpura, and vesiculobullous lesions on the axilla, popliteal fossa and upper abdomen. A biopsy specimen from a pustule showed subcorneal pustules with perivascular polymorphous cellular infiltration, marked dermal edema and necrotic keratinocytes. There was complete resolution of the lesions within 10 days. (Kor J Dermatol 1997;35(l): 160-164)

수종의 보습기제의 피부보습효과에 관한 연구

강호정 ( Ho Jung Kang ),함정희 ( Jeong Hee Hahm ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.6

Background : Moisturize's were t,hought. to increase the hydration of the outer layer of the epidermis. During recent years, new noninvasive methods for assessment. of skin hydration have become available. Objective : The purpose of this study was to evaluat,e and compare the cutaneous hydration ef fect of three moisturizers (hydrophilic base, urea and petrolatum) in healthy females with dry leg skin. Methods : The regression method was applied for evaluating and comparing theeffect of moisturizers. The hydration state was evaluated by Skicon-200 and skin dryness was evaluated by Biosits method. Results: Three moistur zers improved the dry skin condition for the treatment period and for the 10 day regression regression peiod. hnprovement of the hydrophilic base treated site continued for 20 days during the regression period and superior to petrolatum treated site. Conclusion : Three moisturizers improve the stratum cor neum hydration state significantly and its improvement has been continued for about 14days after treatment. Hydrophilic base moisturiz ers showed a better effec than petrolatum based ones. (Kor J Dermatol 1996;34(6): 869-874)

Darier병으로 etretinate 치료중 발생한 포진상 습진

강호정(Ho Jung Kang),함정희(Jeong Hee Hahm) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.5

We report a case of eczema herpeticum associated with secondry staphylococcal infection in a 19 year-old male patient with Dariers disease during tratment with etretinate. Diagnosis was made by the history, clinical feature and histologic examination with light microscope & electron microscope. This patients condition was improved by the treatment with systemic and topical antibiotics within 1 week of admission. (Kor J Dermatol 1902;30(5):710-714)

수종 피부질환에서 피부 각질층의 보습기능에 관한 연구

강호정(Ho Jung Kang),함정희(Jeong Hee Hahm) 대한피부과학회 1993 大韓皮膚科學會誌 Vol.31 No.6

Background: To preserve the natural properties of skin, its waite balance has to be maintained. Properly moisturised skin is soft, supple, luminous, elastic and tonic. Stratum corneum is the bodys main protective barrier agairist the environment along with regulation of water exchange. Pathological factors such as eczema, ichthyosis and psoriasis encourage dehydration of the stratum corneum. Objective : The purpose of t.his study was to evaluate interrelation. hip between the hydration state of the stratum corneum and cutaneous manifestation in patients with psoriasis, diabetes and chronic renal failure undergoing hemodialysis. Methods : Because the cutaneous conductance is an indicator of skin surface hydration state, a water sorption-desorption test of skin was performed. This test furnishes informations of the hygroscopicity and water-hoiding capacity(WHC) of the stratum cornrum in a short time. Results : Hygroscopicity and WHC decreased significantly on th. scaly psoriatic lesion. Hygroscopicity increased significmtly in diabetes with pruritus. In chonic renal failure undergoing hernodialysis, the prehydration state and hygroscopicity decreased. There were no significant differences in prehydration water coritent, hygroscopicity and WHC between pruritic and nonpruritic lesions in diabetes mellitus and chronic renal failure respectively. Conclusion : It is suggested that disturbed hydration function oi tl e stratum corneum, such as decreased hygroscopicity and water-holding capacity on the scaly pscriatic lesion may play an important role in clinical manifestatior. Pruritus in diabetes mellitus and chromic renal failure patients doesnt seem to be the functional disturbance of hydration in stratum corneum, (Kor J Dermatol 1993;31(6):890-895)