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유방의 침윤성 관암종에서 Rb 단백과 Ki-67 표지지수의 상관관계
한홍권,최병선,이태진,박언섭,유재형,김미경 중앙대학교 의과대학 의과학연구소 2002 中央醫大誌 Vol.27 No.2
To evaluate correlations between clinicopthologic factors such as age, tumor size, histologic differentiation and lymph node metastasis, with expression of Rb protein and Ki-67, immunohistochemical study was done on 60 cases of invasive ductal carcinoma of the breast. Rb protein was expressed in 53.3%(32/60) of cases. Poorly differentiated tumors tends to show more increased expression of Rb protein(p=0.012). There was not significant difference according to patient age(p=0.068), tumor size (p=0.073)and lymph node metastasis(p=0.085). Ki-67 albeling index tended to be increased in tumors with large size(p=0.047), poor differentiation (p=0.016) or positive lymph node status(p=0.035). There was a significant correlation between Rb protein expression and Ki-67 labeling index (p=0.014). In conclusion, both Rb protein and Ki-67 labeling index significant reseverse correlation with histologic differentiation of the invasive ductal carcinoma of the breast. But the value of Rb proteinas prognostic factor remained to be studied.
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전호승,조계남,한홍권,윤형구 대한골절학회 2000 대한골절학회지 Vol.13 No.1
Purpose : The nonunion after mid-shaft clavicular fracture is predisposed by refracture, interposition of the soft tissue, complete displacement of the fracture fragment and bony defect with comminuted fracture by the high-energy trauma. Symptomatic nonunion may need surgical treatment. The purpose of this study is to assess the functional and radiological results of the surgical treatment of the symptomatic nonunion of the clavicle. Materials and Methods: We reviewed 10 cases of symptomatic clavicular nonunion managed with surgical treatment from January, 1994 to May, 1997. The age at operation ranged from 26 to 60 years old (average 46.5 years). The average length of follow-up was 1.7 years (range, 1 to 3 years). According to the scoring system of Rowe, the function of the shoulder was evaluated. Results: All cases were united and radiologic union was obtained at 10.2 weeks on average after surgery. On functional results, average score on pain was 9.9(3-12), average score on stability was 24.5(20-25), average score on function was 21.0(10-25). In motion, average score on abduction and forward flexion was 11.0(7-15), average score on internal and external rotation were 3.8(3-5), 3.3(0-5). According to the scoring system of Rowe, excellent in 6 cases, good in 3 cases, fair in 1 cases and the average of the total score were 83.8 Conclusion: We concluded that open reduction and internal fixation by plate or intramedullary device with autogenous bone graft could provide the relief of symptom and effective results of shoulder function in the symptomatic nonunion of the clavicle.
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무지를 제외한 일측 수부에 발생한 수근중수골 관절의 골절 및 탈구 - 증례 보고 -
전호승,조계남,윤형구,한홍권 대한골절학회 1999 대한골절학회지 Vol.12 No.1
Fracture-Dislocations of the ulnar carpometacarpal joints is an uncommon injury. The priorities of management of other more extensive injuries often delay definitive treatment. If such a dislocation is diagnosed early, it can be reduced easily by closed means. We reviewed one case of fracture-dislocation of carpometacarpal joints excluding thumb with stable and pain free carpometacarpal joints in one year after closed reduction and internal fixation.
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