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RISS 인기검색어
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- 저자 : 한상영(Sang Yeoung Han) (검색결과 4 건)
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B 형 간염시 지연성피부과민반응과 T - Cell Subset 에 관한 연구
한상영(Sang Yeoung Han),김치호(Chi Ho Kim),임홍섭(Hong Seop Im),김홍범(Hong Bum Kim),양웅석(Ung Suk Yang),문한규(Han Gyo Moon) 대한내과학회 1988 대한내과학회지 Vol.35 No.3
N/A Hepatitis B virus(HBV) may cause either acute or chronic infection. As HBV is not directly cytopathic for infected hepatocytes, host determined immunologic response is considered a likely pathogenetic mechanism in this disease. The cell-mediated immune response to component antigens of the virus plays an important role in the lysis of infected hepatocytes in acute and chronic HBV-induced hepatitis. This immune response to the virus may be regulated by the balance of inducer (helper) to suppressor T-cell activity. Peripheral blood T lymphocytes and T-cell subsets were analyzed in patients with HBsAg-positive acute hepatitis (AVH) and chronic active hepatitis (CHA). To assess cell- mediated immunity in hepatitis B, the multitest device simultaneously applies seven standardized recall antigens and a 70% w/v glycerine diluent control. Delayed cutaneous hypersensitivity (DCH) responsive- ness is quantified by a score (the sum of the diameters of the indurations) at 48 hours. The OKT4/OKT8, ratio was significantly lower in the A VH and CAH groups than in the control group, and the patient group had an average score in CMI test significantly lower than that of the control group. In conclusion, defective T lymphacyte function in HBsAg-positive AVH 8r CAH patients has been suggested. The multitest system appears to be a safe, rapid and painless means of evaluation DCH, with the potential for detecting changes in cell-mediated immunity in hepatitia B, Additional studies, with longer follow-up periods, will be necessary to assess cell- mediated immunity (CMI) in hepatitis B with the multitest CMI kit.
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문한규(Han Kyu Moon),조중현(Joong Hyeon Cho),김영훈(Young Hoon Kim),한상영(Sang Yeoung Han),김치호(Chi Ho Kim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A The serum ferritin levels were measured by radioimmunoassay in 25 normal subjects and 88 patients with various liver diseases, and compared with serum transaminase activity and with alpha-fetoprotein in liver cirrhosis and primary liver cancer. The results were as follows; 1) The serum ferritin levels in 25 normal subjects were in a range of 27.2 191.0 ng/ml, and the mean value was 88.3+-39.4ng/ml. 2) The serum ferritin levels in various liver diseases were as follows: 500.7+-422.8 ng/ml in acute viral hepatitis, 73.6+64.5 ng/ml in chronic persistent hepatitis, 281.4+-214.7 ng/ml in chronic active hepatitis, 317+- 368.7 ng,'ml in liver cirrhosis, 703.2+-509.7 ng/ml in primary liver cancer with cirrhosis, 383.2+-475.9 ng/ml primary liver cancer without cirrhosis, 734.0+-320.0 ng/ml in cancer metastasis to liver, 252.7+-89.1 ng/ml in obstructive jaundice, 289.3+-117.7 ng/ml in liver abscess. Serum ferritin levels of each disease group were significantly higher than normal control (p<0.01) except chronic persistent hepatitis, and good correlation existed between serum ferritin and serum transaminase activity which suggested that the elevation of the serum ferritin level was due to leakage of storage ferritin by hepatocellular damage. 3) In acute viral hepatitis, on following, the decrease in serum ferritin accompanied with the decreasing of SGPT during recovery stage. 4) In the differential diagnosis between liver cirrhosis and primary liver cancer, measurement of the serum ferritin did not show more significant value than alpha-fetoprotein.
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A 형 혈우병환자에서 방광과 누공을 형성한 혈우병성 위종양 1 예
하철봉,김정완,김치호,송근암,조군제,한상영,나하연,임홍섭,박희옥,이병구 대한내과학회 1988 대한내과학회지 Vol.35 No.4
A hemophilic pseudotumor is a rare complication of hemophilia, defined as a progressive cystic swelling involving muscle, produced by recurrent hemorrhage and accompanied by roentgenographic evidence of bone involvement. Its treatment is very difficult because of the danger of sepsis and continued hemorrhage and necrosis. The best treatment is the prevention of hemorrhage in emophiliacs. Recently, we experienced a hemophilic pseudatumor in a hemophilia A patient with formed a fistula with the urinary bladder, This 36 year old man, diagnosed as a hemophilia at age 3 years, presented with abdominal distension, abdominal pain and hematuria. The abdominal CT scan and cystogram showed a huge right lower abdominal mass which had eroded the right iliac bone and formed a fistula with the bladder. After subs-titutional therapy, the patient improved and was discharged.
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