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최청아,이기백,박성영 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
The redox-responsive MnO<sub>2</sub> nanosheets were loaded into the carbonized boronic acid-conjugated FNPs, which were crosslinked with the carbonized dopamine-conjugated hyaluronic acid (HA) FNPs as extracellular targeting ligands, while the diol of boronic acid-linked catechol groups resulted in pH responsiveness. The MnO<sub>2</sub>-loaded crosslinked FNPs (C-FNP) demonstrated quenching effect, which recovered after glutathione (GSH) treatment and demonstrated excellent stability and tumor-targeting ability. PTX was loaded into the MnO<sub>2</sub>-loaded C-FNP by hydrophobic interactions, and displayed therapeutic efficacy triggered by acidic pH and high GSH concentration. The in vitro bioimaging and chemotherapeutic activities of PTX/MnO<sub>2</sub>-loaded C-FNP were analyzed towards cancer and noncancerous cells. This smart multi-stimuli-responsive system combined with FRET mechanism might open up promising avenues for synergetic targeted drug delivery.
최청아,김슬기,노상규,원현정,이기백,박성영 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Boronic acid could be used for the early detection of bacteria through its affinity-binding reaction with diol groups on the bacterial cell wall. Herein, we describe the use of a diol-modified fluorescent probe (DYE) conjugated to a nanosensor consisting of phenylboronic acid-functionalized fluorescent carbon nanoparticles (FNPs) to allow quenching via the Forster resonance energy transfer(FRET) process. In the presence of glucose-containing bacteria, the DYE in the cyclic ester form will be released from the FNP and replaced by the bacterial cell forming a new cyclic boronate ester bond with the nanoparticle, inducing recovery of the fluorescence. Incredibly, the system was most successful in detecting bacteria in the contaminated river water, thus proving it to be a less expensive and more robust affinity biosensor for the detection of contaminating pathogens in various chemoselective ligand-based environments.
최청아,박성영 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
We have described a novel synthesis method for silica nanoparticles, which involves the combi-nation of these nanoparticles with targetable and non-targetable fluorescent dopamine conjugated hyaluronic acid (HA) by rational chemical dehydration. The resulting HA-decorated silica fluo-rescent nanoparticles, electrostatically linked to form ionic complexes with polyaniline (PANI), possessed high intensity and were monodisperse in solution, near infrared light responsive, and amenable to specific labeling of cancer cell lines. When exposed to near-infrared irradiation, the fluorescent silica within carbonized HA on PANI nanoparticles exhibit photothermal cytotoxicity guided bio-imaging directing between malignant cancer and normal cells through CD44 receptor. This was supported by Korea National University of Transportation in 2017.