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흰쥐 간세포 미토콘드리아에서의 Cadmium 독성작용에 대한 Glutathione 의 영향
김현숙,고기석,최임순 ( Hyun Sook Kim,Ki Seok Koh,Rim Soon Choe ) 한국환경생물학회 1990 환경생물 : 환경생물학회지 Vol.8 No.2
This study was carried out to confirm the non-enzymatic binding between glutathione and cadmium in vitro system, using Sephadex G-15 gel chromatography. Also, it was observed that the mitochondrial respiration, swelling and conformational change in rat liver. In vitro, glutathione bound non-enzymatically to cadmium and the binding ratio of glutathione to cadmium was 1.72. The more amounts of cadmium added to mitochondria, the less state Ⅳ respiration of mitochondria was observed. Added cadmium facilitated mitochondrial swellings and inhibited ultrastructural transformation from a condensed to an orthodox conformation under state Ⅳ respiration. When glutathione was treated prior to addition of cadmium to mitochondria, respiratory rates and conformational changes were almost recovered to control level, and mitochondrial swellings were restored, also.