스마트팜 환경에서 전력소비 감소를 위한 실내외 온도차 기반의 자동화 운용 알고리즘

최인해(In-Hae Choe),안세미(Se-Mi An),조영소(Yeong-So Jo),정승철(Seung-Cheol Jung),최용훈(Yonghoon Choi) 대한전기학회 2019 대한전기학회 학술대회 논문집 Vol.2019 No.11

5-Hydroxytryptamine (5-HT) 이 개의 신장기능에 미치는 영향

고석태(Suk Tai Ko),나한광(Han Kwang Na),최인(In Choe) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.1

5-Hydroxytryptamine(5-HT, serotonin), when given into the vein, produced antidiuretic action accompanied with reduction of glomerular filtration(GFR), renal plasma flow(RPF), osmolar clearance(Cosm) and amounts of sodium or potassium excreted in urine(E_(Na), E_K), with the augmented reabsorption rates of sodium and potassium in renal tubules. 5-HT, when infused into a renal artery, exhibited diuretic action accompanied with the augmented RPF and increased E_(Na), and E_K in only infused kidney. Antidiuretic action of 5-HT infused into the vein was not influenced by ketanserin, 5-HT₂ receptor blockade, given into a renal artery, vein or carotid artery, by methysergide, 5-HT₁ receptor blockade, given into a renal artery, whereas above antidiuretic action was inhibited by methysergide given into vein or carotid artery. Diuretic action of 5-HT infused into a renal artery in only experimental kidney was blocked by ketanserin injected into a renal artery, was not influenced by methysergide administered into a renal artery. Above results suggest that 5-hydroxytryptamine(5-HT) produced the antidiuretic action through central 5-HT₁ receptor and the diuretic action through 5-HT₂ receptor located in renal tubules of kidney.

3차 병원에서 HAART 치료를 받은 HIV 환자의 처방패턴 및 이상지질형증 발생 빈도 분석

박선희(Sun Hee Park),양영모(Young-Mo Yang),최인(In Choe),윤현옥(Hyonok Yoon),최은주(Eun Joo Choi) 대한약학회 2015 약학회지 Vol.59 No.3

Highly active antiretroviral therapy (HAART) has reduced AIDS-related morbidity and mortality; however, it has been associated with metabolic abnormalities including dyslipidemia and dysglycemia depending on the regimens used. The aims of this study were to analyze the prescription patterns of antiretroviral agents and to examine the prevalence of lipid abnormalities among the prescriptions of HAART. The electronic medical records (EMR) of HIV patients were retrospectively reviewed from January 2007 to September 2012 based on our inclusion criteria. The patients who had taken HAART for at least 3 months were included in this study. The lipid profiles of patients on antiretrovirals (ARTs) were collected from his or her laboratory data, and dyslipidemia was defined as total cholesterol (TC) ≥240 mg/dL and triglycerides (TG) >200 mg/dL. Eighty-four prescriptions were discovered during the study period. Twenty-three prescriptions were the combination of two nucleoside reverse transcriptase inhibitors (NRTIs) and one non-nucleoside reverse transcriptase inhibitor (NNRTI). Fifty-three prescriptions were the combination of two NRTIs and one protease inhibitor (PI) and thirty-nine prescriptions of them included a PI booster. Eight prescriptions were the combination of two NRTIs and one integrase inhibitor. The Incidence of hypertriglyceridemia among the patients receiving HAART was totally about 41.7% (2NRTIs+PI regimen vs. 2NRTIs+NNRTI regimen vs. 2 NRTIs+integrase inhibitor regimen, 52% vs. 12.5% vs. 25%), but there was no incidence of hypercholesterolemia. This study investigated that the prescription medication patterns and dyslipidemia associated with lipid abnormalities among HIV patients receiving HAART. The types of HAART prescription regimens had an effect on the occurrence of hypertriglycemia. Further studies related to metabolic abnormalities and adverse effects of HIV patients on ARTs are needed in the near future.

3차 병원 류마티스 관절염 환자에서 항종양괴사인자 제제 치료 후 임상반응 및 관찰 평가 분석

박선희(Sun Hee Park),최인(In Choe),최은주(Eun Joo Choi) 대한약학회 2020 약학회지 Vol.64 No.1

Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes joint damage and bone erosion. Antitumor necrosis factor (anti-TNF) agents are first-line biological Disease-Modifying Anti-rheumatic Drugs (DMARDs), which can reduce the disease activity of RA. The objective of this study is to evaluate and observe the clinical responses and parameters following anti-TNF administration. We analysed the medical records of patients who were administered anti-TNF agent for RA, from September 2012 to August 2015, retrospectively. The clinical responses (ESR, CRP, swollen joint count, tender joint count) and adverse effect monitoring factors (AST, ALT, white blood cell count, hemoglobin, neutrophils count, platelet count, serum creatinine) were observed before the drug administration, and follow-up observation were also made at 3, 9, and 15-month post-administration. 104 patients of 306 patients were selected based on inclusion and exclusion criteria, and were administered etanercept (n=38), adalimumab (n=46), and infliximab (n=20). After 3 months, the clinical response significantly decreased, regardless of the type of anti-TNF agents used, and the levels were maintained up to 15 months (p<0.05). Platelet, WBC and neutrophils count decreased after 3 months of anti-TNF agent administration, regardless of the type of anti-TNF agents used, and the levels were maintained up to 15 months (p<0.05). Serum creatinine showed constant increase over the course of 15 months. Further related multi-institutional prospective studies are needed to confirm and optimize the study.

Clonidine 의 개 신장작용에 대한 Yohimbine 의 영향

고석태,최인 한국응용약물학회 1993 Biomolecules & Therapeutics(구 응용약물학회지) Vol.1 No.2

Effect of yohimbine, a specific antagonist for presynaptic adrenoceptor, on the renal action of clonidine, a specific presynaptic adrenoceptor agonist, was investigated in dog. Clonidine, when given intravenously, produced diuretic action accompanied with augmentation of osmolar and free water clearance (Cosm and C_(H2O)), and elicited the increase of amounts of sodium and potassium excreted in urine (E_(Na) and E_k). These actions of clonidine were inhibited by yohimbine either injected intravenously or infused into a renal artery. Clonidine, when infused into a renal artery, produced antidiuretic action accompanied with decreased of glomerular filtration rate (GFR) and renal plasma flow (RPF), and exhibited the reduced amounts of sodium and potassium in urine. These actions of clonidine injected into a renal artery were blocked by yohimbine administered either into vein or into a renal artery. Above results suggest that yohimbine block the renal action of clonidine only in central system, do not in kidney.

지방유제가 다른 고영양수액제의 안정성 비교

문홍섭,최인,조아라,김상인 한국병원약사회 2000 병원약사회지 Vol.17 No.2

Available lipid emulsions made from soybean or safflower oil are classified as long chain triglyceride (LCT). In contrast, medium chain triglycerides (MCT) have different physical properties and are metabolized by other pathways. Because the medium chain fatty acids are smaller than long-chain fatty acids, they are more water soluble and metabolized faster. To compare of stability the two type of total nutrient admixture (TNA), authors studied in 4 types of formular TNA based on LCT (Intralipose) and MCT/LCT based TNAs had smaller particle sizes when compared with LCT based TNA without significance, but had no significant difference in appearance, pH, hyperoxides and osmolarity. Therefore, We conclude that two types of TNAs were stable for 3 days at room temperature and under refrigeration. In addition to, MCT/LCT (1:1, IntraMCT) at room temperature and under refrigeration (4℃). In results, MCT/LCT based TNAs are more physicochemically stable and available to patients than LCT based TNAs.

5-Hydroxytryptamine(5-HT)이 개의 신장기능에 미치는 영향

고석태,나한광,최인 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2

5-Hydroxytryptamine(5-HT, serotonin), when given into the vein, produced antidiuretic action accompanied with reduction of glomerular filtration(GFR), renal plasma flow(RPF). osmolar clearance(Cosm) and amounts of sodium or potassium excreted in urine(E_Na, E_K), with the augmented reabsorption rates of sodium and potassium in renal tutbules. 5-HT, when infused into a renal artery, exhibited diuretic action accompained with the augmented RPF and increased E_Na and E_K in only infused kidney. Antidiuretic action of 5-HT infused into the vein was not influenced by ketanserin, 5-HT₂receptor blockade, given into a renal artery, vein or carotid artery, by methysergide, 5-HT₁receptor blockade, given into a renal artery, whereas above antidiyretic action was inhibited by methysergide given into vein or carotide artery. Diuretic action og 5-HT infused into a renal artery in only experimental kidney was blocked by ketanserin injected into a renal artery, was not influenced by methysergide ad inidtered into a renal artery. Above results suggest that 5-Hydroxytryptamine(5-HT) produced the antidiuretic action through central 5-HT₁receptor and the diuretic action through 5-HT₂receptor located in renal tubules of kidney.