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동과자가 Glucose Oxidase로 손상된 혈관내피세포에 미치는 영향
서은아 ( Eun A Seo ),최승석 ( Natthew Seung Suk Choi ),이병찬 ( Byung Chan Lee ),이재규 ( Jai Kyoo Lee ),이강창 ( Kang Chang Lee ),정종길 ( Jong Gil Jeong ),신민교 ( Min Kyu Shin ),송호준 ( Ho Joon Song ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.2
N/A Objectives : It has been demonstrated that oxidative stress of oxygen radicals is involved in vascular disorder. The aim of this study was to evaluate the cytotoxicity of glucose oxidase (GO) and protective effect of herb extract on GO-induced cytotoxicity in the cultured vascular endotherial cell (VEC) of mouse. Methods : Cytotoxic effect of GO and protective effect of Benincasae Semen (BS) were performed by MTT assay, after cultured VEC were incubated in the media containing 1-30 mU/ml GO for 6 hours. Results : GO decreased cell viability in dose-and time-dependent mannner, and BS increased cell viability decreased by GO-induced cytotoxicity in these cultures. Conclusion : From above the results, GO has cytotoxic effect, and herb extract, BS is very effective in blocking GO-induced cytotoxicity in cultured VEC.