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최순용,이낙영 충남대학교 기초과학연구소 2000 忠南科學硏究誌 Vol.27 No.2
In this paper, we studied the performance of a production control plan which forms a keynote of every promising business area. The production control plan along with diversitifying its business items is a main concern of each company myth an active business. We investigated classifying characteristics, processes, product types, and computation of the necessary product time per each unit process, which altogether comprise the whole work processes of the products of the Korea Minting and Security Printing Co.(KOMSEP). The most suitable manufacturing structure for stable and systematic production and inventory management has been sought by setting the most at able total stock level for bank bills(l0.000 won. 5.000 won, and 1,000 won bills) and checks. This requires calculation of the product lead time per each unit process from order to delivery, which matches the whole work processes required for production in KOMSEP.
Insect Ornithine Decarboxylase (ODC) Complements SPE1 Knock-Out of Yeast Saccharomyces cerevisiae
최순용,Hee Yun Park,Aron Paek,Gil Seob Kim,정성은 한국분자세포생물학회 2009 Molecules and cells Vol.28 No.6
Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the biosynthesis of polyamines, which are essential for cell growth, differentiation, and proliferation. This report presents the characterization of an ODC-encoding cDNA (SlitODC) isolated from a moth species, the tobacco cut-worm, Spodoptera litura (Lepidoptera); its expression in a polyamine-deficient strain of yeast, S. cerevisiae; and the recovery in polyamine levels and proliferation rate with the introduction of the insect enzyme. SlitODC encodes 448 amino acid residues, 4 amino acids longer than B. mori ODC that has 71% identity, and has a longer C-terminus, consistent with B. mori ODC, than the reported dipteran enzymes. The null mutant yeast strain in the ODC gene, SPE1, showed remarkably depleted polyamine levels; in putrescine, spermidine, and spermine, the levels were > 7, > 1, and > 4%, respectively, of the levels in the wild-type strain. This consequently caused a significant arrest in cell proliferation of > 4% of the wild-type strain in polyamine-free media. The transformed strain, with the substituted SlitODC for the deleted endogenous ODC, grew and prolif-erated rapidly at even a higher rate than the wild-type strain. Furthermore, its polyamine content was signifi-cantly higher than even that in the wild-type strain as well as the spe1-null mutant, particularly with a very continu-ously enhanced putrescine level, reflecting no inhibition mechanism operating in the putrescine synthesis step by any corresponding insect ODC antizymes to SlitODC in this yeast system.
최순용,Gil-Soon Park,Sung Yoon Lee,Ji Yeon Kim,Young Kook Kim 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.5
In the course of searching for cholesteryl ester transfer protein (CETP) inhibitors from natural sources, a new type of CETP inhibitor, [10]-dehydrogingerdione (1), was isolated from the extract of rhizomes of Zingiber officinale Roscoe. By NMR spectroscopic analysis of its 1HNMR, ^13C-NMR, and ^1H-^1H COSY, HMBC, HMQC and NOESY, more precise structure, compared with its originally proposed structures, of [10]-dehydrogingerdione has been elucidated. This active compound inhibited human plasma CETP with IC_50 values of 35 μM.