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최소영(So Young Choi),김세중(Sei Joong Kim),조영업(Young Up Cho),박재영(Jae Young Park),박정미(Jeong Mi Park),주영채(Young Chae Chu),최윤미(Yun Mee Choe),최선근(Sun Keun Choi),허윤석(Yoon Seok Heo),이건영(Keon Young Lee),안승익(Seung 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.5
Purpose: Apocrine carcinoma of the breast is rare and there is confusion about the criteria of its histopathologic diagnosis. The purpose of this study is to investigate the clinical and pathologic characteristics of the disease. Methods: 9 patients diagnosed with apocrine carcinoma or apocrine carcinoma in situ and 1,009 patients diagnosed with non-apocrine carcinoma of the breast from April 1999 to March 2008 were retrospectively analyzed. Results: The mean age of the patients with apocrine carcinoma was 52.3 year. 5 patients (55.6%) among 9 patients with apocrine carcinoma were postmenopausal. There were 2,1 and 6 patients with stage 0, Ⅰ and Ⅱ disease, respectively according the TNM stage. These demographic and clinical differences between the patients with apocrine carcinoma and non-apocrine carcinoma were not significant. Only four patients (44.4%) were preoperatively diagnosed with apocrine carcinoma or apocrine carcinoma in situ. By surgical biopsy, additional 5 patients were diagnosed as apocrine carcinoma. In the immunohistochemical study, Bcl-2 was positive in one (12.5%) of 8 patients. p53 was positive in 4 (44.4%) of 9 patients. Expressions of estrogen and progesterone receptor were positive only in two patients (22.2%) with weakly positive staining. Androgen receptor was positively expressed in all cases (100%) of apocrine carcinoma. Overexpression of c-erb-B2 was detected in four patients. Conclusion: Treatment modality and prognosis of apocrine carcinoma are similar as non-apocrine carcinoma. But its preoperative diagnosis is more difficult than that of non-apocrine carcinoma and it shows different expression of hormone receptor. Further study is needed for the development of new hormonal therapy using androgen.
열대마 영여자 추출물의 항응고 및 혈소판 응집저해 활성
전수경(Su-Gyeong Jeon),최소영(So-Young Choe),임경란(Kyung-Ran Im),이종필(Jong-Pil Lee),박준홍(Jun-Hong Park),손호용(Ho-Yong Sohn) 한국생명과학회 2024 생명과학회지 Vol.34 No.3
열대마로 알려진 Dioscorea alata L.는 전 세계 650여종의 마 중에서도 가장 많이 소비되고 있으며, 적도, 아적도 지역에서 광범위하게 재배하고 있다. 실제 중국과 인도에서는 주요 식용자원 및 약용으로 이용되고 있다. 최근 국내에서는 기존의 단마 및 장마에 비해 2배 이상 높은 수확량을 나타내는 열대마 재배가 증가하고 있으며, 열대마에 높은 관심이 집중되고 있다. 그러나 현재까지 열대마의 주아(영여자)에 대한 연구는 전무한 실정이다. 본 연구에서는 국내 단마 및 열대마 영여자의 에탄올 추출물을 조제하여, 단마 영여자와 비교하여 열대마 영여자의 영양특성 및 추출물의 항혈전 활성을 평가하였다. 그 결과, 열대마 영여자는 특유의 황색과 함께 영양적으로 우수하며, 단마 영여자와는 달리, 열대마 영여자 추출물은 1.25 mg/ml 농도에서 아스피린보다 우수한 트롬빈, 프로트롬빈 및 혈액응고인자 저해를 나타내어 강력한 항응고 활성을 나타냄과 동시에 혈소판 응집저해 활성도 우수하였다. 또한 열대마 영여자 추출물은 2.5 mg/ml 농도까지 인간 적혈구에 대한 용혈활성도 전혀 나타나지 않았다. 이러한 결과는, 열대마 영여자가 새로운 항혈전 소재로 개발 가능함을 제시하고 있다. Dioscorea alata L, commonly known as tropical yam is the most widely consumed yam species among the 650 yam species belonging to the Dioscoreacea family. It is extensively cultivated in tropical and subtropical regions and is a major food source in Africa and India. Also, it is used for medicinal purposes, particularly in China and Taiwan, for its anti-inflammatory properties. In comparison to other yam varieties such as D. batatas or D. opposita, the tropical yam has gained popularity in Korea due to its higher yield per unit area. In this study, the nutritional characteristics and anti-thrombosis activity of the aerial bulbils of D. alata L. tropical yam were compared to those of D. opposita. The results showed that the aerial bulbils of tropical yam exhibited nutritional characteristics and potent anticoagulant activity compared to those of domestic yam varieties. The bulbils extract of tropical yam showed superior anticoagulant activities against thrombin, prothrombin and blood coagulation factors. Furthermore, the bulbils extract of tropical yam exhibited strong platelet aggregation inhibition at 0.25 mg/ml and showed no hemolytic activity up to a concentration of 2.5 mg/ml. These findings suggest the potential development of high-value anti-thrombosis agents utilizing the aerial bulbils of tropical yam.
류정아 ( Jung A Ryu ),강동균 ( Dong Kyoon Kang ),권오흔 ( Oh Heun Kwon ),이혜련 ( Hye Ryun Lee ),최소영 ( So Young Choe ) 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2010 한국식품저장유통학회지 Vol.17 No.4
본 연구는 건조 연근을 포장방법(PE 필름, PP 필름, 마대, 종이봉투)과 저장온도(-5, 0, 10, 20℃)를 달리하여 품질의 변화를 알아보기 위해서 수분함량, 경도변화, 색도를 조사하였다. 저장기간 동안 수분의 함량은 PE, PP 포장재에서 종이봉투 및 마대 처리구 보다 수분함량이 높았으며, 저장온도가 낮을수록 수분함량이 낮게 나타났다. 한편, 마대와 종이봉투 포장재는 온도에 따른 시료간의 수분함량 차이에 있어서 PE와 PP의 포장재와 달리 큰 차이를 나타냈다. 색상은 -5℃에 저장한 마대 및 종이봉투는 저장 330일까지 h값이 안정적인 경향을 나타내었으나 0, 10℃, 20℃에서 저장한 마대, 종이봉투 포장재는 안정적이지 못한 경향을 나타냈다. 경도는 온도에 의해 약간 차이가 나지만 PE와 PP포장재가 다른 포장재보다 경도 값이 높았으며 또한 부패현상, 갈변반응 억제도 효과적인 결과를 나타냈다. The effects of packaging materials and storage temperature on the quality of dried lotus roots (NelumbonuciferaG.) were studied during 330 days of storage. Using four commercial types of packaging, (PE [polyethylene] film bags, PP [polypropylene] film bags, gunny roll, and paper bags), and four different storage temperatures (-5, 0, 10, and 20℃), changes in moisture content, hardness, color, and sensory qualities of dried lotus roots were investigated. The moisture contents of dried lotus roots stored in PE and PP film bags were higher than those of roots stored in gunny and paper bags. A major difference in moisture content was apparent when roots stored in gunny bags and paper bags were compared. Hue angle values were stable in roots stored in gunny and paper bags at all temperatures. Hardness decreased slightly with increased storage time in PE and PP film bags. Decay rate and marketability of roots stored in PE and PP film bags at -5℃ were acceptable. The results showed that dried roots packaged with PE and PP were stable in quality, in contrast to roots stored in gunny and paper bags.