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- 저자 : 최석주(Suck Joo Choi) (검색결과 1 건)
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급성심근경색증에서 정맥내 투여 Urokinase 의 혈전용해 효과
노영무(Young Moo Ro),오동주(Dong Joo Oh),심완주(Wan Joo Shim),최석주(Suck Joo Choi),송관규(Gwan Gyu Song),박창규(Chang Kyu Park),유승관(Seung Kwan Ryu),서순규(Soon Kyu Suh) 대한내과학회 1988 대한내과학회지 Vol.34 No.2
N/A To evaluate the thrombolyutic efficacy and safety of Urokinase (UK), an intravenous (IV) bolus of 20,000 units/kg was administered in 15 patients with acute evolving transmural myocardial infarction 6.15(2.5~8.0) hours after the onset of symptoms. Recognition of myocardial reperfusion was based upon the reperfusion scores according to the following indirect clinical criteria; rapid relief of chest pain, rapid resolution of ST segment elevation (∑ST reduction by ? 70%within 90 minutes), ischemic arrhythmia or A-V block and CK wash-out phenomenone, Signs of reperfusion began to occur 30 to 90 minutes after the IV bolus of UK. Of the 15 patients, 8(53.3%) had one or more of the signs of reperfusion and 6 (40%) had reperfusion scores of ?4, which indicates definite reperfusion according to the indirect reperfusion scoring system we employed. Those who received UK within 6 hours after the onset of chest pain, reperfusion was achieved in 71.4% (5 of 7 patients). Transient gum bleeding was the only side effect, which was seen in 1 patient (6.7%). These findings suggest that IV bolus of 20,000 units/ kg UK within 6 hours after the onset of chest pain is an effective and safe method to achieve reperfusion in patients with acute transural myocardial infarction. Since there was no significant complication on 20,000 units/kg of UK, higher dose than 20,000 units/kg can be used to improve reperfusion in acute evolving myocardiaI infarction,
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