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결핵 환자에서 결핵균 베타 ( β ) 항원에 대한 혈청 항체가의 의의
서지원(Ji Won Suhr),김남재(Nam Jae Kim),홍석철(Seok Cheol Hong),정연채(Yeon Chae Jeong),김주옥(Ju Ock Kim),김선영(Sun Young Kim),백태현(Tae Hyun Paik),김화중(Hwa Jung Kim),최병태(Byong Ai Choi) 대한내과학회 1990 대한내과학회지 Vol.39 No.6
N/A We extracted beta antigen from M. tuberculosis Aoyama B and purified it from the cell extract of Mycobacterium tuberculosis by affinity chromatography with 5F3F2 monoclonal antibody. We measured the values of IgG, IgM, and IgA antibodies to this beta antigen using ELISA method in patients with tuberculosis and normal healthy controls. The results are summarized as follows: 1) The mean ELISA values of IgG and IgA antibodies to purified beta antigen in the serum of 73 tuberculous patients and 100 normal controls were 0.5560±0.2879 and 0.2177±0.1394, 0.3732±0.2011 and 0.1530±0.1272 (optical density: O.D.), respectively. This difference between the tuberculosis patients and normal controls was statistically significant (p<0,001). 2) On the results of sputum AFB stain, patients with negative AFB, 1+, 2+, and 3+ AFB findings showed significantly elevated levels of IgG antibodies to beta antigen in the value of 0.4930±0.2300, 0.7884±0.3560, 0.5736±0.3820, and 0.5310±0.1680, respectivly, when compared to that of the normal controls. Elevations of IgA antibodies to beta antigen were noted in patients with 1+, 2+, and 3+ AFB on smear staining with the value of 0.2510±0.1550, 0.2540±0.1370, and 0.2440±0.1240 when compared to that of the normal controls. 3) The mean values of IgG and IgA antibodies to purified beta antigen in patients with moderately advanced pulmonary tuberculosis were 0.5425±0.3580, 0.2128±0.1620, and in patients with far advanced pulmonary tuberculosis, 0.5336±0.2793 and 0.2721±0.2210, which were more significantly elevated than in the normal controls of 0.3732±0.2911 and 0.1530±0.1272, respectively(p<0.05). 4) In patients with superficial cervical tuberculous lymphadenitis, the mean values of antibody to purified beta antigen were not significantly different from that of the normal controls. 5) In patients with tuberculous pleurisy, the mean value of IgG antibody to purified beta antigen was elevated to 0.5520±0.4090 compared to 0.3732±0.2011 of the normal controls (p<0.005). 6) The mean values of antibodies to purified beta antigen follwing treatment showed a desreased tendency, but there was no statistical significance. In conclusion, patients with tuberculosis showed statistically significant elevations of IgG and IgA antibodies to purified beta antigen, and the measurement of these values may be useful for the diagnosis of tuberculosis-related diseases.
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