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알코올 의존 환자에서 Mirtazapine과 SSRI의 효과에 관한 전향적 비교 연구
천영일(Young- Il Cheon),이태경(Tae- Kyung Lee),이종일(Jong- Il Lee) 한국중독정신의학회 2004 중독정신의학 Vol.8 No.2
Objectives:There have been growing concerns about the pharmacological treatment of alcohol dependence. Serotonergic medications, particularly the selective serotonin reuptake inhibitors (SSRIs), have been extensively evaluated for the treatment of alcoholism. Of serotonergic agents, especially the effect of ondansetron, a 5-hydroxytryptamine-3 (5-HT3) antagonist, has also been studied. However mirtazapine, noradrenergic and specific serotonin 5-HT2 and 5-HT3 antagonist, have not yet been investigated. This study was performed to compare the efficacy of mirtazapine versus SSRIs in the treatment of alcohol dependence. Methods:The subjects were 46 inpatients with alcohol dependence. They were admitted to the Alcohol & Drug Addiction Center in Seoul National Hospital. They were randomly assigned into one of the two groups:mirtazapine group (n=20) or SSRIs group (n=26). All subjects received the psychosocial treatment program for alcoholism. All of the subjects were assessed by scales:The Korean version of Alcohol Use Disorders Identification Test (AUDIT-K), Obsessive Compulsive Drinking Scale (OCDS), Beck Depression Inventory (BDI), Aggression Questionnaire (AQ), and Three-dimensional Personality Questionnaire (TPQ) at baseline and 8 weeks later. Results:There were no differences between mirtazapine group and SSRIs group in baseline BDI, AUDIT-K, OCDS, AQ, TPQ scores and demographic characteristics. After 8-week treatment period, BDI, AUDIT-K and OCDS scores decreased significantly in total subjects. Mirtazapine group had a greater reduction of the BDI scores than SSRIs group at week 8. The aggression scores did not decrease significantly during treatment;the difference between the two groups was not significant. There was no significant change on TPQ. Conclusion:Both mirtazapine and SSRIs are effective to comorbid depressive symptoms and compulsive drinking of alcohol dependence. Moreover mirtazapine is resulted to be more effective in treating depressive symptoms of alcohol-dependent patients. Consequently, our results provide evidences that mirtazapine may be an effective pharmacological treatment for alcohol dependence with comorbid depression and compulsive drinking.
성영권,김성진,천영일,박근영 고려대학교 공학기술연구소 1992 고려대학교 생산기술연구소 생기연논문집 Vol.28 No.1
Traditional DLTS (deep level transient spectroscopy) could measure the interface state density located from the majority carrier band edge to the midgap. In this paper, we obtained information on the interface state density for whole band gap by measuring the DLTS on illuminated state. As the result, this method was sensitive and easy to analyze and determine the various interface papameters such as interface state density, capture cross section, emission rate and activation energy. In addition, we investigated the (-) B-T stress dependence of the interfae state density.