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인슐린 비의존형 당뇨병환자에서 혈관합병증과 Lipoprotein ( a ) 의 관계
김선희(Seon Hee Kim),채희복(Hee Book Chai),박중열(Joong Yeol Park),민원기(Won Ki Min),김우건(Woo Kun Kim),김기수(Ghi Su Kim),이기업(Ki Up Lee) 대한내과학회 1997 대한내과학회지 Vol.52 No.3
N/A Objectives: High serum Lp(a) concentration is associated with a high risk of coronary artery disease(CAD). This study was initiated to determine whether increased Lp(a) levels are associated with diabetic vascular complications in Korean patients with NIDDM. Methods: A total of 183 NDDM patients were studied cross-sectionally for the presence of various vascular complications. Lp(a) levels were measured by 1-step sandwich ELISA method. Results: The patients with overt proteinuria had higher Lp(a) levels than the patients with mormo- albuminuria or microalbuminuria(26.8mg/dl vs 13.8 mg/dl and 17.3mg/dl, p<0.05), The patients with proliferative retinopathy and/or those treated by photocoagulation had higher Lp(a) levels than those without retinopathy or those with background retinopathy(34.1mg/dl vs 13.3mg/dl and 16,9mg/dl, p<0.05), The Lp(a) levels were also higher in the patients with CAD than those without CAD(30.9mg/ dl vs 16.3mg/dl, p<0.05). Multiple logistic regression analysis revealed that high Lp(a) levels were independantly associated with CAD and severe diabetic retinopath3. Conclusion: High Lp(a) levels are associated with CAD and proliferative retinopathy in Korean patients with NIDDM.