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십이지장 궤양에 있어 혈청 Pepsinogen 1 치의 의의 - 궤양 발생의 유전적 또는 후천적 요인으로서의 의미 -
차수강(Su Gang Cha),김태호(Tae Ho Kim),이준성(June Sung Lee),김재준(Jae Jun Kim),김용태(Yong Tae Kim),윤용범(Yong Bum Yoon),송인성(In Sung Song),최규완(Kyoo Wan Choi),김정룡(Chung Yong Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.2
N/A Background: Peptic ulcer is a heterogenous disease which has genetic or acquired factors in the development of the disease. Serum pepsinogen I (PG I) was reported as a marker of the genetic factors. Rut it is less reported about the relations between serum PG I and acquired factors in the development of the disease. The aim of this study was to evaluate serum PG I levels as the genetic or acquired factors in the development of duodenal ulcer. Methods: Fasting serum PG I levels were tested in 85 patients with duodenal ulcer, 64 their family members, and 52 normal controls. Results: 1) Serum PG I levels in duodenal ulcer patients (104±44ng/ml) and their family members (74±29ng/ml) were significantly higher than that of the control subjects (57±24ng/ml)(p<0.05). 2) The PG I levels of the family in their family members (78±30ng/ml) who had duodenal ulcer patient with elevated PGI levels in their family were somewhat higher than that of the family members (67±19ng/ml) who had the duodenal ulcer patients with normal PG I levels, but the difference did not acquire statistical significance (p<0.05). 3) The mean serum PG I level of smoker (111±47ng/ml) was higher than that of non-smoker (84±35ng/ml). 4) The mean serum PG I levels did not change in duodenal ulcer patients even after the treatment with H2-receptor blocker. Conclusion: These results suggested that serum PG I levels may be useful as a genetic marker in duodenal ulcer disease, but might be affected by acquired risk factor like smoking as well.
대장 흑피증 1예 : 석유 주입과 연과된 증례 A Case with history of rectal instillation of petroleum
송인성,정현채,김재준,최규완,김정룡,윤용범,차수강 대한소화기내시경학회 1990 Clinical Endoscopy Vol.11 No.1
Melanosis coli is the brownish black discoloration of the colon due to accumulation of pigment containing macrophages in lamina propria. The nature and source of this pigment is controversial but many studies have suggested that the pigment is related to lipofuscin. Melanosis coli has been reported to be closely associated with prolonged administration of anthraquinone purgatives. But this condition is sometimes associated with colonic polyp colon cancer, rediation therapy or non-anthraquinone purgatives administration. Moreover the fact that melanosis coli could be found in subjects who never used purgatives suggested that, even though chronic consumption of anthraquinone purgatives seems to play a major role, other factors may be involved in the pathogenesis of melanosis coli. We presented a case of melanosis Coli in a 47-year-old female with history of rectal instillation of petroleum for control of hemorrhoids.
송인성,김용태,최규완,김정룡,이준성,윤용범,차수강,윤병철 대한소화기내시경학회 1992 Clinical Endoscopy Vol.12 No.1
Gastric lymphoma occupies about i-7% of gastric cancer and is the mast common type of extranodal lynuphama. To evaluate the ieridoegopic morphologic characteristics of gastric lymphoma, we analysed the endoecon finds in 5 patients with pathologically-proven gastric lymphoma. 1) The mean ague vvas 53.4(t 13.6) years and the ratio of male to female was 2 : 1. 2) The most frmqwent symptom was epagastric pain(89%), followed by weight loss(25%). indigestion, nausea, vomiting(13%), fever(7%); dysphaga(%) and abdominal distension(2%). 3) The ntcst common size of gastric Imphoma was body of stomach(3l%), followed by antrum(29%)sid entire stomach(16%). 4) Gastrascopy revealed-ulcerative lesion in 17 cases(3896), ulcerative and caass lesion in 14 case(31), erive lesion in 7 cases(15% inass lesion 4 case(9%) and mixed type in 3 case. 5) As a ,initial endoscopic impression gastric lymphoma was suggested in 5 cases(11%), advanced fastric cancer in 29 cases(65%), early gastric; cancer in 4 cases(9'), leiomyoma in 5 cases(tl)and benign gastric peptic ulcer in 2 cases(4). The grs endasaapic findings which suggested gastxic lymphoma initially were preserved distensibiliy of stosnach wall compared to the severity of disease involvement (3 cases), and submucosa tumor with ulcer those margin was heaved-up(2 cases). 6) Ptho[logic reports of biopsy specimens were malignant lymphoma in 35 cases(78%), adenaclrcioma in 3 cases, undifferentiated carcinoma in 2 cases, and chronic superficial gastritis in 5 ciases. 7) In conclusion, gastric lymphoma couldn't be differentiated from the other disease by their endoscopie gross morphology a1ane except a few cases and even endascopic biopsy were not able to detect malignant lyrnplloma cell in about 22% patients. So recognition of specific endoscopic patterns along with high index of suspicion and'multiple biapsy may lead to earlier diagnosis of gastric lymphoma.