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- 저자 : 차성재(Seong Jae Cha) (검색결과 28 건)
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차성재,박성준,Seong Jae Cha,M,D,and Sung Jun Park,M,D 대한갑상선-내분비외과학회 2003 The Koreran journal of Endocrine Surgery Vol.3 No.1
The authors present a clinical analysis of 69 cases of primary hyperparathyroidism during the last 32 years from 1963 to 1994 which were reported in Korean Medical Journals. There were 69 patients, 21 males and 48 females, with a male to female ratio of 1 to 2.3. The age distribution was between 4 months and 65 years. The presenting clinical manifestations were musculoskeletal symptoms (66.7%), renal symptoms (49.3%), and general weakness (21.7%) in that order of frequency. There were 2 patients with asymptomatic hypercalcemia. The mean preoperative serum Ca and P levels were 13.1 mg% and 2.4 mg%. The mean postoperative serum Ca and P levels were 8.0 mg% and 2.7 mg%. The mean preoperative and postoperative PTH levels were 3275 pg/dl (normal range; 220∼660 pg/dl) and 392 pg/dl. Preoperative localization was done using ultrasonogram, computed tomogram, thallium-technetium subtraction scan, and arteriogram. Positive localization was made in 84.8% (28/33), 72.7% (24/33), 84.2% (16/19), and 100% (9/9), respectively. In one patient, magnatic resonance imaging was performed and positive localization was made. The location of the lesion was more common in the lower part of thyroid than the upper part and on the left side rather than the right side. There were 7 patients with ectopic locations including the thoracic inlet (2), intrathymus (1), intrathyroidal (1), mediastinum (2), and right subclavicular (1). All patients were treated surgically. The final histopathologic findings were single adenoma in 63, carcinoma in 3, and primary hyperplasia in 2 patients. There was 1 patient with double tumors composed of adenoma and carcinoma. (Korean J Endocrine Surg 2003;3:32-38)
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경련이 흰쥐 대뇌겉질의 NADPH-diaphorase와 Calbindin D28k 양성 신경세포에 미치는 영향
차성재(Seong Jae Cha),허영범(Young Buhm Huh),박 찬, 이원규(Won Kyu Lee),김정혜(Jung Hye Kim),유진화(Jin Hwa Yoo),안희경(Hee Kyung Ahn) 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.6
Kainic acid (KA)를 흰쥐에게 투여하여 경련을 유발한 후 대뇌겉질에 분포하는 NADPH-d와 calbindin D28k 신경세포의 변화에 대하여 알아보고자 NADPH-d 조직화학과 calbindin D28k 면역조직화학을 시행하였다. 또한 nNOS와 calbindin D28k mRNA의 양적인 변화를 확인하고자 RT-PCR을 시행하여 다음과 같은 결과를 얻었다. 대뇌겉질에서 constitutive NADPH-d 신경세포의 염색강도를 영상분석기의 microdensitometry 방법으로 측정한 결과 NADPH-d의 염색성은 대조군에 비해 KA를 투여한 전 실험군에서 통계적으로 유의성있게 증가한 염색성을 나타내었다. 특 히 KA 투여 1일과 3일군에서 강한 염색성을 보였고 그후 6일과 12일군에서는 시간경과에 따라 염색성이 약해지는 경향을 보였다. Calbindin D28k의 면역염색성을 측정한 결과는 NADPH-d 신경세포의 측정결과와 비슷하였다. KA 투여군에서는 대 조군에 없는 새로 발현된 NADPH-d 세포들이 관찰되며, 특히 운동겉질, 몸통감각겉질, 섬겉질, 청각겉질, 시각겉질, 후각뇌바깥겉질과 후각뇌주위겉질에 밀집되어 분포하였다. Calbindin D28k 신경세포들중에 새로 발현된 세포들이 KA 투여군 1일과 3일군의 운동영역과 몸통감각영역에서 관찰되었 다. 6일과 12일군에서는 대뇌겉질 전 영역에서 새로 발현된 calbindin D28k 신경세포들이 관찰되지 않았다. NADPH-d와 calbindin D28k의 이중염색결과 새로 발현된 NADPH-d 신경세포들이 밀집된 부분에서는 calbindin D28k 신경세포의 수가 대조군에 비해 적은 양상이었다. 대뇌겉질에서 nNOS mRNA는 KA 투여군에서 증가된 양상이었으나 calbindin D28k mRNA는 1일군에서는 약간 감소되는 경향을 보였으나 다른 군에서는 큰 차이가 없었다. 따라서 이 연구에서는 NOS와 calbindin D28k가 각각 다른 신경세포의 발현변화와 mRNA의 변화를 보여 물질에 따라서 KA에 의한 영향을 받는 기전이 다를 것으로 생각되었다. 또한 새로 발현된 NADPH-d 및 calbindin D28k 신경세포와 염색성이 증가된 NADPH-d 신경세포는 경련 후의 대뇌혈류조절과 신경활성에 영향을 줄 것으로 생각되었다. Administration of kainate (KA) results in the induction of epileptiform activity and limbic motor seizures. Nitric oxide (NO) is a gaseous messenger that plays a role in neural transmission, long term potentiation, depression and cerebral blood flow. NO is formed by NO synthase (NOS) from arginine. NO mediates the increase in cerebral blood flow during seizure activity. However, the production site of NO has not been clearly defined. Recent report showed that constitutive NOS may be induced under certain conditions. Therefore, the present study was aimed to investigate the change of NOS and calbindin D28k in the rat cerebral cortex following seizure. Rats were injected with KA and killed at 6 hours, 1, 3, 6 and 12 days after seizure. Expressional change of nNOS and calbindin D28k was assessed by histochemistry, immunohistochemistry and RT-PCR in the rat brain. Induced NADPH-d positive neurons were observed in the cerebral cortex of 1, 3, 6 and 12 days after seizure and found in specific cortical areas, such as motor cortex, somatosensory cortex, auditory cortex, visual cortex, ectorhinal cortex and perirhinal cortex. The level of nNOS mRNA increased at 1, 3, 6 and 12 days after seizure compared with control group. Induced calbindin D28k positive neurons were observed in motor cortex and somatosensory cortex 1 and 3 days after seizure. The level of calbindin D28k mRNA in the cerebral cortex was slightly decreased at 1 day after seizure. Therefore, in this study, the induced NADPH-d, calbindin D28k positive neurons and upregulated NADPH-d positive neurons may influence the cerebral blood flow and neuronal activity in the cerebral cortex during post-seizure period.
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차성재(Seong Jae Cha),박성준(Sung Jun Park),임현묵(Hyen Muck Lim) 대한두경부종양학회 1997 대한두경부 종양학회지 Vol.13 No.2
결론적으로 저위험군환자에서는 수술방법 및 수술후 보조적인 치료법인 방사선요드동위원소 치료 및 갑상선 흐르몬 억제 치료가 생존을 증가에 별다른 영향을 주지 않으리라 생각된다. 이러한 이유는 사실상 이들 환자에서는 사망률의 위험성이 거의 없어 생존율을 확인할 방법이 없기 때문이다. 따라서 저위험군에서는 광범위한 수술방법을 피하고 고위험군에서는 환자 개개인의 상태에 따라 수술방법이 선택되어야 하며 갑상선 전절제술은 확실한 예후의 증가나 다른 적절한 치료 방법이 없을 경우 조심해서 선택되어야 된다고 사료된다. Background: There is considerable controversy concerning the most appropriate surgical treatment of patients with DTC. Objectives: In order to selection of the appropriate surgical treatment for DTC, we have analyzed the outcome of the different types of surgical treatment in low and high risk groups of DTC. Materials and Methods: From January 1968 through december 1980, a total of 71 patients with DTC were treated surgically at our institution. According to Cady and Rossi's scoring system, the patients were divided into low risk and high risk groups. Results: Seventy percent of patients were defined as low risk group with a 4% death rate whereas 30% of patients at high risk with a death caused by thyroid cancer in 38%(p<0.05). There was no difference in mortality between ipsilateral lobectomy and total thyroidectomy in both low and high risk groups(p>0.1). Conclusion: In our study, total thyroidectomy was not benefit in high risk group. These results suggested that total thyroidectomy must be selected carefully and based on clear evidence of major improvement in outcome or absence of other suitable surgical approaches. However, follow up study of more cases will be needed for accurate determination of the efficacy of total thyroidectomy in high risk group.
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유방암에서 Claudin-1과 ZO-1 단백 발현 감소와 임상-병리학적 인자와의 연관성
김민준(Min Joon Kim),차성재(Seong Jae Cha),박성일(Sung Il Park),박성준(Sung Jun Park),장인택(In Taik Chang),김범규(Beom Gyu Kim),최유신(Yoo Shin Choi),이태진(Tae Jin Lee) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.6
Purpose: Tight junction proteins are either over-expressed or suppressed in some cancers. These suppressions of claudin-1 and ZO-1 protein are known to have a significant relationship with the progression of breast cancer. The authors reviewed 42 cases of breast cancer and the staining status of claudin-1 and ZO-1 in order to evaluate Claudin-1 and ZO-1 as clinicopathologic risk factors. Methods: Immunohistological staining for Claudin-1 and ZO-1 was performed in 42 post-operative pathologically diagnosed infiltrating duct carcinoma specimens. The rate of expression was compared with the clinical record, the pathological diagnosis, the estrogen receptor and progesteron receptor status and the c-erbB2 gene to evaluate the protein expression-breast cancer progression relationship and to investigate the expressions of Claudin-1 and ZO-1 as a prognostic factors in breast cancer. Results: The claudin-1 and ZO-1 expressions were both decreased in all the post-operative specimens. The claudin-1 expressions were significantly decreased 100%, 82.4% and 66.7% as the histologic grade increased. The ZO-1 expressions were shown in 44.8% of the lymph node metastasis negative group and in 7.7% of the lymph node positive group. The expression of ZO-1 decreased by 53.3%, 28.6% and 0%, with statistical significance, as the stage increased. Conclusion: The claudin-1 expressions were decreased in the poorly differentiated group, i.e., a high histologic grade, and the ZO-1 expressions were decreased in the lymph node positive group and in the high stage cancer. This shows the possibility of Claudin-1 and ZO-1 as factors for tumorigenesis and progression and as prognostic factors in breast cancer.
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위선암종에서 핵의 Retinoic Acid Receptor (RAR) 및 cAMP Response Element Binding Protein (CREB)의 면역조직화학적 발현양상
한호선,김용석,박중민,최유신,차성재,김미경,지경천,Han, Ho-Sun,Kim, Yong-Seok,Park, Joong-Min,Choi, Yoo-Shin,Cha, Seong-Jae,Kim, Mi-Kyung,Chi, Kyung-Choun 대한위암학회 2008 대한위암학회지 Vol.8 No.4
목적: 인체 내 여러 조직에서 상피세포의 분화 및 증식에 중요한 역할을 담당한다고 알려진 retinoic acid (RA)와 여러 유전자들에서 전사조절인자로 성장관여 유전자들의 활성화에 관여하며 세포증식 및 분화에 매우 중요한 세포내 조절인자인 CREB의 발현정도와 위선암종간의 상호 연관성 및 병리학적 인자들과의 관계를 관찰하였다. 대상 및 방법: 중앙대학교 의과대학 용산병원에서 1998년 1월부터 2007년 12월까지 위절제술을 시행 받고 위선암종으로 진단받은 환자의 위조직표본 중 보존상태가 양호한 파라핀 포매괴 150예를 연구대상으로 조직 표본에서 면역 조직화학적 염색을 통해 관찰하였다. 결과: 1. RAR의 발현은 장형 위선암종(72.2%)에서 미만형 위선암종(40.5%)보다 높게 나타났으며(P<0.01), 림프절 전이가 있는 경우(74.7%)가 림프절 전이가 없는 경우(49.2%)보다 의미 있는 발현양상을 나타냈다(P<0.01). 2. cAMP response element binding protein (CREB)의 발현은 장형 위선암종(69.4%)에서 미만형 위선암종(38.1%)보다 높게 나타났으며(P<0.01), 림프절 전이가 있는 경우(71.1%)가 림프절 전이가 없는 경우(47.8%)보다 높은 발현양상을 나타냈다(P<0.01). 3. 총 150예의 위선암종에서 RAR은 63.3% (95/150), CREB은 60.7%(91/150)에서 발현을 나타냈다(P<0.01). 결론: 이상의 결과로 RAR과 CREB은 조직학적 분화도 및 종양의 전이와 관련이 있고, 이들의 발현이 장형 위선암종에서의 생물학적 악성도에 관한 예후인자로서 관련이 있으나 이들의 발현이 위선암종에 미치는 생물학적 기전에 대한 추가 연구가 필요하다. Purpose: Transcriptional factors of CREB (cAMP response element binding protein) are involved in regulating the gene expression in response to a variety of signaling pathways. The proteins produced by the CREB genes play key roles in many physiological processes, including memory and long-term potentiation. The retinoic acid receptor (RAR) axis mediates epithelial cell differentiation and proliferation in many tissues. This study examined the expressions of RAR and CREB and their relationship with the clinicopathologic factors and their significance. Materials and Methods: The levels of the RAR and CREB expressions were measured in 150 gastric adenocarcinomas by performing immunohistochemical staining. Results: 1. An RAR protein expression was found in 63.3% of the adenocarcinomas (95/150) and a CREB expression was found in 60.7% (91/150) of the adenocarcinomas. 2. An RAR protein expression was found in 72.2% (78/108) of the intestinal type adenocarcinomas and in 40.5% (17/42) of the diffuse type adenocarcinomas (P<0.05). Based on the depth of invasion, an RAR protein expression was found in 58.3% (14/24) of the T1 adenocarcinomas, in 61.9% (13/21) of the T2 adenocarcinomas, in 63.5% (61/96) of the T3 adenocarcinomas, in 77.8% (7/9) of the T4 adenocarcinomas and in 74.7% (62/83) of the adenocarcinomas with lymph node metastasis and in 49.2% (33/67) of the adenocarcinomas without lymph node metastasis (P<0.01). 3. A CREB expression was found in 69.4% (75/108) of the intestinal type and in 38.1% (16/42) of the diffuse type (P>0.05). Based on the depth of invasion, a CREB expression was found in 50% (12/24) of the T1 adenocarcinomas, in 52.4% (11/21) of the T2 adenocarcinomas, in 64.6% (62/96) of the T3 adenocarcinomas, in 66.6% (6/9) of the T4 adenocarcinomas, in 71.1% (59/83) of the adenocarcinomas with lymph node metastasis and in 47.8% (32/67) of the adenocarcinomas without lymph node metastasis (P<0.01). 4. The RAR protein and CREB expressions coincided in 71.4% of the gastric adenocarcinomas and a significant correlation between them was found (P<0.05). Conclusion: We found a significant relationship between the expression of RAR and CREB and the histology and lymph node metastasis of gastric cancer. Further studies are needed to confirm their biologic meaning in gastric carcinogenesis.
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