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인간 유두종 바이러스로 인해 보웬 모양 변화를 보인 국한성 수장 저각화증 1예
정우석 ( Woo Seok Jeong ),진우정 ( Woo Jung Jin ),문승현 ( Seung Hyun Moon ),황보현 ( Hyun Hwangbo ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.8
Circumscribed palmar or plantar hypokeratosis is a rare condition characterized by the occurrence of an erythematous, well-circumscribed, and depressed macule or patch on the palms or soles. Histopathologically, it is characterized by sharp, stair-like abrupt thinning of the horny layer between the affected and unaffected skin. The pathogenesis of this condition remains unclear. Recently, the human papilloma virus has been implicated as a possible etiological contributor. Circumscribed palmar or plantar hypokeratosis usually shows a benign course. Previous reports have not described malignant changes in these lesions. However, its association with actinic keratosis has been reported in a previous case. We report a case of circumscribed palmar hypokeratosis showing bowenoid epidermal change with expression of the human papilloma virus types 6 and 16 in a patient who was successfully treated with ingenol mebutate gel and cryotherapy. (Korean J Dermatol 2018;56(8):489∼493)
안면부 총상으로 인한 하악골 정중부 결손환자의 장골이식 치험례
김명진(Myung Jin Kim),김민형(Min Hyung Kim),정인원(Jn Won Jung),김판식(Pan Sik Kim),진우정(Woo Jung Jin) 대한구강악안면외과학회 1982 대한구강악안면외과학회지 Vol.8 No.1
Early planning of overall treatment is important for patients with avulsion defects of mandible as a result of fireann injuries. Bone grafting procedure may be necessary for restoration of mandibular continuity, contour, and function. Autogenous bone has been considered the best bone grafting material, but one should, first of all, consider the general principles and mechanisms of bone grafting. The authors have experienced the complicated case of free iliac bone graft for the mandibular symphysis discontinuity defect, which caused by gun shot wound. Many problems have occured during intermediate and reconstructive phases such as mandibular medial contraction, postoperative infection, graft bone resorption, and improper restoration of masticatory function, etc.. The results are as follows: 1. Successful bone grafting of the mandibular symphysis area is the most difficult to accomplish, due to adverse influences such as aversion and rotation forces, soft tissue tension, and diminished vascularity of the graft region, etc.. 2. Treatment must be predicted on through examination, early organized planning, and continuing evaluation of patients status through the various stages of treatment. 3. In cases of mandibular symphysis defect, it is important to maintain the remaining proximal fragments in their proper position and alignment to prevent mandibular medial migration. 4. The bone graft should performed under asepsis and should do adequate antibiotics coverage. 5. The osteogenic capacity of the periosteum in bone graft procedure is considered very important. 6. The solid free iliac bone should be decorticated and that is brought in close contact with a highly vascular connective tissue and must remain in intimate contact with this soft tissue for adequate blood supply.
문승현 ( Seung Hyun Moon ),진우정 ( Woo Jung Jin ),정우석 ( Woo Seok Jeong ),이택근 ( Taek Geun Lee ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2018 大韓皮膚科學會誌 Vol.56 No.8
Wells’ syndrome or eosinophilic cellulitis is usually observed in adults who present with pruritic, erythematous and edematous plaques associated with papules or vesicles. It is a rare inflammatory dermatosis of unknown etiology showing an eosinophil-mediated immune response. Classical histopathological features observed in patients are eosinophil-predominant inflammatory infiltration and marked dermal edema, along with ‘flame figures’. An 11-year-old boy presented with edematous plaques surmounted by vesicles on his abdomen and lower extremities. A month prior to presentation, these skin lesions occurred on other parts of his abdomen; however, they resolved spontaneously within a week. Skin biopsies from the recurrent lesions showed features consistent with Wells’ syndrome and a few molluscum bodies in the epidermis. Laboratory tests showed peripheral eosinophilia. We concluded that Wells’ syndrome in this young patient was caused by preceding molluscum contagiosum infection. (Korean J Dermatol 2018;56(8):499∼503)
Murine Melanoma B16 세포주의 항암제감수성 시험에 관한 실험적 연구
구명삼,진우정 全北大學校 齒醫學硏究所 1992 전북치대논문집 Vol.10 No.1
Anticancer drug sensitivity assays were performed using cotorimetric[3-(4.5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide(MTT)] assay and dye exclusion assay <DEA> on cell line. Comparison of the MTT assay with DEA is essential prior to its use in clinical screening study. Murine melanoma B16 cell lines were exposed to bleomycin, CDDP, Vinblastine for one hour(2.0×10^4 viable cells/well) and then cultured for four days in MEM containing 10% bovine serum for dye exclusion assay. In [MTT] assay, cells to be tested were exposed for one hour and continuously(5.0×10^3 viable cells/well). Four Hour before the culture end, added the MTT on media measured the absorbance with an ELISA reader at a wavelength of 490㎚. The results were as follows ; 1. Cancer cells were sensitive to bleomycin, CDDP at all concentrations and bleomycin revealed relatively good cytotoxicity than that of CDDP in [DEA] assay(P<0.05). 2. In [MTT] assay, cancer cells were sensitive to high concentration of all drygs and medium concentration of vinblastine for 1 hour exposure(P<0.01). 3. In [MTT] assay, cancer cells were sensitive to medium and high concentration of all drugs and low concentration of VINB for vinblastine continuous exposure(P<0.01). 4. In the comparision of chemosensitivity test between [DEA] and [MTT] assay, the result was correlated(γ=0.99, P<0.05).
양상일,박경정,진우정,신효근 全北大學校 齒醫學硏究所 1988 전북치대논문집 Vol.6 No.1
Thirty three healthy adult patients who needed extraction of impacted lower third molar were studied. We focused on the changes of blood glucose and autonomic nervous system during surgical extraction and additionally the psychologic factor using DAS-J was checked to find the relationship with this study. This study was divided into before operation, immediatly before operation and immediatly after operation. The obtained results were as follows : 1. Blood pressure was increased immediatly after operation but not significant. Pulse rate was more increased in immediatly after operation than before operation(p<0.05). 2. Blood glucose was more increased in immediatly before operation than in before operation(p<0.05), and it was highly significant in immediatly operation(p<0.01). 3. The degree of surgical trauma (operation site, amount of local anesthetics and operation time) was not influenced of the changes of blood glucose.. 4. The changes of blood glucose and autonomic nervous system were not related to the psychologic factor measured by DAS-J.