천식 환아에서 집먼지진드기 감작이 기도과민성과 폐기능에 미치는 영향

진소희,김은옥,박강서 대한 소아알레르기 호흡기학회 2007 Allergy Asthma & Respiratory Disease Vol.17 No.4

Purpose : Aeroallergens are generally known to us as risk factors for the persistence of asthma. House dust mites are major aeroallergens in Korea. However, the associations between house dust mites sensitization, bronchial hyperresponsiveness and pulmonary function are still controversial. Methods : One hundred eighteen children aged 5-12 years with mild to moderate asthma were enrolled. Each subject underwent the pulmonary function test, the methacholine challenge test, and the skin prick test with aeroallergens, and total serum immunoglobin (Ig)E levels. The non-sensitization group was defined when skin prick test results are all negative for common aeroallergens. The sensitization group was defined when skin test results are positive for Dermatophagoides pteronyssinus or Dermatophagoides farinae. Results : In the house dust mites sensitization group, increased serum total IgE and decreased methacholine PC20 were noted. There was no significant difference in pulmonary functions between sensitization and non-sensitization groups. In the sensitization group, methacholine PC20 correlated with prebronchodilator %FEF25-75% (r=0.346, P=0.008) but did not correlate with %FVC, %FEV1 and FEV1/FVC. In the sensitization group, methacholine PC20 and pulmonary function did not correlate with total IgE or age. Conclusion : The house dust mites sensitization in asthmatic children correlated with increased bronchial responsiveness but did not correlate with decreased pulmonary functions. These findings support the role of house dust mite sensitization in the modulation bronchial responsiveness. 목 적 : 흡입항원 감작은 소아 천식의 발현과 유지에 중요한 인자이다. 집먼지진드기가 주항원인 우리나라 소아 천식 환자에게 집먼지진드기 감작이 미치는 영향은 중요할 것으로 생각되는데 집먼지진드기 감작과 기도과민성, 폐기능간 연관성은 아직 논란이 있어 본 저자들은 그 연관성을 알아보고자 이 연구를 시행하였다. 방 법 : 1995년 5월부터 2007년 4월까지 전주 예수병원 소아과에 내원하여 천식으로 진단되었던 중등도 이하의 환아 중 피부 단자 검사와 폐기능 검사를 모두 시행하였던 5-12세의 118명을 대상으로 하였다. 대상 환아는 우리나라에서 흔한 흡인성 항원의 피부 단자 시험 상 모두 음성인 소아를 비감작군으로, 집먼지진드기 항원에 양성반응을 보인 군을 감작군으로 구분하여 혈청 총 IgE, 메타콜린 PC20, 폐기능 지표(FVC, FEV1, FEV1/FVC, FEF25-75%)를 비교하였고, 집먼지진드기 감작군에서 혈청 총 IgE, 기도과민성, 폐기능, 나이 사이의 상관관계를 평가하였다. 결 과 : 혈청 총 IgE와 기도과민성은 집먼지진드기 감작군이 비감작군에 비해 유의하게 높게 나타났다. 폐기능은 집먼지진드기 감작군과 비감작군 간에 의미 있는 차이가 없었다. 기관지 확장제 사용 후 폐기능은 예측치에 비해 양 군 모두 감소하였으나 차이는 없었다. 감작군에서 PC20은 pre BD %FEF25-75%와 상관관계가 있었으며(r= 0.346, P=0.008) %FVC, %FEV1, FEV1/FVC와는 상관관계가 없었다. 감작군에서 PC20은 혈청 총 IgE, 나이와 상관관계를 보이지 않았다. 감작군에서 총 IgE는 폐기능과 상관관계가 없었으며 나이는 pre BD FEV1/FVC와 상관관계가 있었으며(r=-0.207, P=0.045) %FVC, %FEV1, %FEF25-75%와는 상관관계가 없었다. 결 론 : 본 연구에서 집먼지진드기에 감작된 천식 환아는 비감작된 환아에 비해 높은 기도과민성을 보였으나 폐기능은 차이를 보이지 않았다. 즉 집먼지진드기 감작이 소아 천식에서 기도과민성의 조절인자로 생각된다.

연꽃 외 1편

진소희 고요아침 2016 한국동시조 Vol.- No.2

표준 소개 - 네트워크 구축을 위한 장비 규모산정 지침

진소희,박근우,이문길,Jin, So-Hui,Park, Geun-U,Lee, Mun-Gil 한국정보통신기술협회 2017 TTA저널 Vol.171 No.-

소규모 센터 병원의 초기 간이식 마취 경험: 이대목동병원

진소희,정락경,우재희,홍근 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.4

Objectives: Liver transplantation (LT) is the only treatment for end stage of liver failure. In Korea, annually it has been performed 1,300 cases. Most of LTs are performed in large volumes centers. More than half of centers performing LT in Korea are low volume Bhospital and started a LT program recently. We present our four-year experiences and outcomes of anesthesia for LT since 2013. Methods: Anesthetic and surgical outcomes of 49 consecutive patients who received LT (living donor LT, 21 cases; deceased donor LT, 28 cases) between April 2013 and April 2017 were analyzed retrospectively. Results: All patients were adult, with the mean age of 53.5±9.2 years. The most common cause of original liver diseases was hepatitis B virus-related liver cirrhosis (40.8%). The mean MELD (Model for End-stage Liver Disease) score was 18.8±10.7. Postreperfusion syndrome was observed in 34.7%, which were all controlled by calcium, norepinephrine, ephedrine and epinephrine. The mean postoperative intensive care unit stay of deceased donor LT recipients (13.6±9.0 days) was significantly longer than that of living donor LT recipients (8.0±3.3 days). There was no intraoperative mortality in patients receiving LT. Thirty-day post-transplant survival rate was 93.8% and 3-year survival rate was 88.6 %. The most common postoperative complication was pneumonia. Conclusion: We have started LT successfully with multidisciplinary team’s steady effort. Adaptation and setting up LT protocol, adequate equipment, proper training at established transplant centers are essential to begin a successful LT program.

거주지 주변 교통량과 뇌혈관질환 유병률과의 관련성

진소희, 이준엽, 배현규, 최원철, 김용대, 김헌 충북대학교 의과대학 충북대학교 의학연구소 2019 忠北醫大學術誌 Vol.29 No.1

본문 참고

천식 환아에서 집먼지진드기 감작이 기도과민성과 폐기능에 미치는 영향

진소희 ( So Hee Jin ),김은옥 ( Eun Ok Kim ),박강서 ( Kang Seo Park ) 대한소아알레르기 및 호흡기학회 2007 소아알레르기 및 호흡기학회지 Vol.17 No.4

화자의 성별에 따른 한국형 주파수중요함수 및 절대전달함수 비교

허소희(So-hee Heo),오홍엽(Hong-yeop Oh),진인기(In-Ki Jin) 한국청각언어재활학회 2018 Audiology and Speech Research Vol.14 No.4

Purpose: The speech intelligibility index (SII) represents the contribution of audible speech information within given frequency bands to speech intelligibility. Generally, speech intelligibility performance depends on the gender of the speaker. The purpose of this study was to compare how a speaker’s gender affects band-importance functions (BIFs) and absolute transfer functions (ATFs), which are important components of the SII. Methods: This study consisted of 78 subjects. The SII data for male speakers was obtained from a previous study. The SII data for female speakers was obtained using the same procedure as the previous study. Hearing-In-Noise Test sentences were used as stimuli. Intelligibility scores were measured in 42 filters at 5 signal-to-noise ratios. The BIFs and ATFs were derived using a nonlinear optimization procedure, and then the BIFs and ATFs of the different genders were compared. Results: The BIF and ATF of different genders have different characteristics. In the case of the BIF, the gap between the different genders ranged between 0.2% (1,170Hz) and 4.0% (8,500 Hz) depending on the frequency band. In the case of the ATF, the female speakers’ ATF was steeper than the male speakers’ ATF. Conclusion: The results of the current study indicate that gender can be an important factor for predicting intelligibility. Female speakers’ speech seems particularly more intelligible than male speakers’ speech when measured at the same audibility levels in Korean SII modeling.

한국어 이명주요기능설문지의 검사 - 재검사 신뢰도 검증 및 간소화 버전 제안

허소희,진인기 한국청각언어재활학회 2019 Audiology and Speech Research Vol.15 No.4

Purpose: The purpose of this study is to verify the test-retest reliability of the Korean version of the tinnitus primary function questionnaire (K-TPFQ) and to propose a simplified version of the K-TPFQ. Methods: In the test-retest reliability measure of the K-TPFQ, 31 participants were asked to complete the K-TPFQ on two occasions. Correlation between the results of the two questionnaires was confirmed by Pearson correlation coefficient. Then, a total of 110 subjects participated in the proposed, simplified version. Following factor analysis of the K-TPFQ, three items with high factor loadings for each subscale were selected as simplified version items. Internal consistency and validity were analyzed for the 12 items of the simplified version of the K-TPFQ. Results: The results of the test-retest reliability analysis of K-TPFQ showed significantly high correlations in all items, subscales, and total scores (r = 0.598-0.927). As a result of factor analysis, all items in each subscale showed high communalities. Therefore, we extracted 3 items with high content validity and high factor loadings from each subscale and adopted a total of 12 items for the simplified version. The results of the internal consistency test of the simplified version showed good validity and significantly high internal consistency of all items and subscales (α = 0.839-0.950). Conclusion: This study verified the high reliability and validity of the K-TPFQ. Therefore, it can be used to effectively evaluate the secondary effects of tinnitus in domestic clinics. In addition, the simplified version will reduce the time for evaluating tinnitus sufferers.

자연음을 활용한 부분 차폐의 이명 재활 효과

정승엽,허소희,오홍엽,유제은,진인기 한국청각언어재활학회 2019 Audiology and Speech Research Vol.15 No.1

Purpose: The purpose of the current study was to identify tinnitus rehabilitation effects using partial masking with nature sounds. Methods: Nineteen people who had chronic subjective tinnitus participated in this study. Each participant was randomly assigned to one of two groups: counselling and sound therapy using nature sounds or counselling and sound therapy using broadband noise (BBN). Two types of nature sounds were used: the sound of waves and the water of a stream. The partial masking was applied to the sound therapy in both groups and the rehabilitation period was three months. The Tinnitus Handicap Index was administered before and after the rehabilitation. Results: The average decrease in tinnitus as shown by the questionnaire was 15.92% for the nature sound therapy group and 8.43% for the BBN therapy group. Statistical significance was observed only in the nature sound therapy group (p < 0.05). For effect size (Cohen’s d) of the tinnitus rehabilitation, the nature sound therapy group was 1.03 (large effect) and the BBN therapy group was 0.58 (moderate effect). Conclusion: Results of the current study showed that sound therapy using nature sounds was more effective than sound therapy using BBN in a short period of tinnitus rehabilitation. Although further studies are required, results of the current study indicate that the effect of the tinnitus rehabilitation may differ, depending on the characteristics of the sound stimulus.

이명 재활을 위한 소리치료 방법과 적용

정승엽,허소희,오홍엽,유제은,진인기 한국청각언어재활학회 2019 Audiology and Speech Research Vol.15 No.1

Sound therapy is known to be a useful treatment option for tinnitus rehabilitation. The purpose of this paper was to review sound therapies that reported effects of tinnitus masking or tinnitus relief. Four sound therapies were reviewed: masking sound therapy, sequential sound therapy, sound therapy for Tinnitus Retraining Therapy, and notched sound therapy. Each sound therapy was reviewed for purpose of the therapy and definition, protocol of the sound therapy, effects of tinnitus relief or masking, usefulness, and limitations. Many researchers have investigated sound therapies using above mixing point sounds, at or below the mixing point sounds, and notched sounds. Most researchers reported that sound therapy is effective on tinnitus, but there is inconsistency regarding the extent of the masking or relief effects. Few researchers reported a sound therapy using sequential sounds. Although some studies have shown efficacy for these sound therapies, further studies are required for more reliable results. Although various sound therapies have identified positive effects of tinnitus relief or masking, information about selecting the appropriate rehabilitation method for each tinnitus sufferer is insufficient. However, the results of this paper will provide a basic guideline for audiologists or clinicians selecting a sound therapy for people who have tinnitus.